The influence of age, gender and the FKBP5 genotype on subjective health complaints in the Norwegian working population

Sannes, Ann-Christin; Christensen, Jan Olav; Nielsen, Morten Birkeland; Gjerstad, Johannes

doi:10.1016/j.jpsychores.2020.110264

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…In the study of Menz et al, the participants ranged from 36 to 92 years old, with a mean of 64 years, whereas our sample was younger, with a range of 18–65, and a mean of 40 years old. Studies report that in women, levels of subjective health complaints were highest among those above 50 years of age [ 29 ]. In addition, degenerative bone disorders due to age can cause back pain in an older population [ 30 ], even more so in women due to menopause.…”

Section: Discussionmentioning

confidence: 99%

Custom-Made Foot Orthoses as Non-Specific Chronic Low Back Pain and Pronated Foot Treatment

Castro-Méndez

Palomo-Toucedo

Pabón-Carrasco

et al. 2021

IJERPH

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Excessive foot pronation has been reported as being related to chronic low back pain symptoms and risk factors in sports-specific pathologies. Compensating custom-made foot orthotics treatment has not been entirely explored as an effective therapy for chronic low back pain (CLBP). This study aims to observe the effects of custom-made foot orthoses, in subjects with foot pronation suffering from CLBP. A total of 101 patients with nonspecific CLBP and a pronated foot posture index (FPI) were studied. They were randomized in two groups: an experimental one (n = 53) used custom-made foot orthotics, and the control group (n = 48) were treated with non-biomechanical effect orthoses. The CLBP was measured using the Oswestry Disability Index (ODI) Questionnaire and a visual analogue scale (VAS), both for lower back pain. The symptoms were evaluated twice, at first when the subject was included in the study, and later, after 4 weeks of treatment. The analysis of outcomes showed a significant decrease in CLBP in the custom-made foot orthoses participants group (p < 0.001 ODI; p < 0.001 VAS). These findings suggest that controlling excessive foot pronation by using custom-made foot orthoses may significantly contribute to improving CLBP.

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Section: Discussionmentioning

confidence: 99%

Custom-Made Foot Orthoses as Non-Specific Chronic Low Back Pain and Pronated Foot Treatment

Castro-Méndez

Palomo-Toucedo

Pabón-Carrasco

et al. 2021

IJERPH

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“…A 5-ml fasting venous blood sample was collected from every participant between 07:00 and 09:00 at the workplace. According to the relevant references ( Roy et al, 2010 ; Fudalej et al, 2015 ; Sannes et al, 2020 ; Womersley et al, 2022 ), the genotype information of SNPs in the Chinese Human Genome (CHB) and the gold standard ( i.e., r 2 = 0.8, MAF>15% standard), the HapMap database ( http://hapmap.ncbi.nlm.nih.gov/ ) and Haploview software ( http://www.broad.mit.edu/mpg ) were used to select target tag SNP loci in this study ( Wang et al, 2022 ). Genomic DNA was isolated and purified from the samples using a whole blood genome extraction kit (Beijing Think out Sci-Tech Co., Ltd).…”

Section: Methodsmentioning

confidence: 99%

“…As many studies have reported, FKBP5 variants have been linked to neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder and cognitive impairment, all of which share some symptoms with sleep disturbance ( Wang, Shelton & Dwivedi, 2018 ; Hernández-Díaz et al, 2019 ; Terrelonge et al, 2022 ). In addition, a study reported a potential association between the FKBP5 rs9470080 variant and subjective health complaints, in which the FKBP5 rs9470080 CC genotype was associated with poor sleep quality complaints in the female working population ( Sannes et al, 2020 ). Since rs1360780 , rs3800373 and rs9470080 are likely functional variants, we decided to focus on these particular SNPs.…”

Section: Introductionmentioning

confidence: 99%

Association of job stress, FK506 binding protein 51 (FKBP5) gene polymorphisms and their interaction with sleep disturbance

Li¹,

Wang²,

Liu³

et al. 2023

PeerJ

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Background Sleep disturbance is an outcome of multiple factors including environmental and genetic influences. Job stress, a complex environmental factor, likely affects sleep quality, significantly reducing the quality of life of workers. Additionally, FK506 binding protein 51 (FKBP5) may be a pathogenic factor for sleep disturbance as it regulates hypothalamic–pituitary–adrenal (HPA) axis activity, where HPA axis has been found to be involved in the regulation mechanism of sleep and stress response. Objectives The main aim of this study was to investigate the association between job stress and FKBP5 gene polymorphism as well as their interaction with sleep disturbance in Chinese workers; to date, these relationships have not been explored. Methods This is a cross-sectional study. A total of 675 railway workers (53.8% male) completed a short Effort-Reward Imbalance questionnaire and the Pittsburgh Sleep Quality Index. The SNaPshot single nucleotide polymorphism (SNP) assay was carried out by screening for FKBP5 SNPs in every participant. Generalized multifactor dimensionality reduction (GMDR) was used to identify the strongest G×E interaction combination. Results The findings showed that job stress was significantly associated with sleep disturbance; specifically, scores on the PSQI subscales (sleep disturbance, sleep medication, and daytime dysfunction) exhibited significant differences between the two job stress groups (X2 = 18.10, p = 0.01). Additionally, the FKBP5 SNP rs1360780-TT (adjusted odds ratio [AOR] = 4.98, 95% confidence interval [CI] = 2.80–8.84) and rs3800373-CC genotype (AOR = 2.06, CI = 1.10–3.86) were associated with an increased risk of sleep disturbance. Job stress and rs1360780 and rs3800373 variants showed a high-dimensional interaction with sleep disturbance as determined by the GMDR model. Conclusion The FKBP5 gene may increase susceptibility to job stress and result in sleep disturbance, especially in the presence of negative work-related events. These findings contribute to the field of sleep disturbance prevention and treatment.

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The association of sex, age and FKBP5 genotype with common somatic symptoms: A replication study in the lifelines cohort study

Ballering

Ori

Rosmalen

2021

Journal of Psychosomatic Research

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The influence of age, gender and the FKBP5 genotype on subjective health complaints in the Norwegian working population

Cited by 4 publications

References 34 publications

Custom-Made Foot Orthoses as Non-Specific Chronic Low Back Pain and Pronated Foot Treatment

Custom-Made Foot Orthoses as Non-Specific Chronic Low Back Pain and Pronated Foot Treatment

Association of job stress, FK506 binding protein 51 (FKBP5) gene polymorphisms and their interaction with sleep disturbance

The association of sex, age and FKBP5 genotype with common somatic symptoms: A replication study in the lifelines cohort study

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