The association of sex, age and FKBP5 genotype with common somatic symptoms: A replication study in the lifelines cohort study

Ballering, Aranka V; Ori, Anil P.S.; Rosmalen, Judith

doi:10.1016/j.jpsychores.2021.110510

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…As a first example, twin studies have demonstrated that pain‐ and non‐pain‐dominated FSS including recurrent headache co‐aggregate, have a modest common genetic and strong environmental component, and can be separated from anxiety and depression 22 . A recent genome‐wide heritability analysis of a large population cohort showed that 12.1% of the phenotypic variance in common somatic symptom levels including headache can be explained by single nucleotide polymorphisms 23 …”

Section: Shared Etiopathogenesis and Pathophysiological Mechanismsmentioning

confidence: 99%

“…22 A recent genome-wide heritability analysis of a large population cohort showed that 12.1% of the phenotypic variance in common somatic symptom levels including headache can be explained by single nucleotide polymorphisms. 23 Second, there is a female preponderance in migraine, as in most types of primary headache disorders (with the exception of cluster headache); in chronic pain and non-pain functional disorders that has been attributed to both sex and gender mechanisms. 17,24 Third, patients with chronic pain and non-pain conditions tend to have elevated perceived stress and mental tension, catastrophizing as well as negative mood, especially depression and anxiety compared to symptom-free control subjects.…”

Section: S Hared E Tiopathog Ene S Is and Pathophys Iolog Ic Al Mecha...mentioning

confidence: 99%

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Migraine in the context of chronic primary pain, chronic overlapping pain disorders, and functional somatic disorders: A narrative review

2022

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Objective To contextualize migraine as the most common primary headache disorder in relation to other chronic primary pain and non‐pain functional somatic and mental conditions. Background Migraine is increasingly understood as a sensory processing disorder within a broader spectrum of symptom disorders. This has implications for diagnosis and treatment. Method Narrative review based on a search of the literature of the last 15 years on the overlap of migraine with other symptom disorders. Results Migraine as the prototypical primary headache disorder not only comprises many non‐headache symptoms in itself, it also shows high comorbidity with other chronic pain and non‐pain conditions (e.g., fibromyalgia syndrome, irritable bowel syndrome, functional non‐epileptic seizures, depression, anxiety, and posttraumatic stress disorder). Such “symptom disorders” share several etiological factors (e.g., female preponderance, psychological vulnerability) and psychophysiological mechanisms (e.g., altered sensory processing, pain expectancy). These facts are acknowledged by several recent integrative conceptualizations such as chronic primary pain, chronic overlapping pain conditions, or functional somatic disorders. Accordingly, migraine management increasingly addresses the total symptom burden and individual contributors to symptom experience, and thus incorporates centrally acting pharmacological and non‐pharmacological, that is, psychological and behavioral, treatment approaches. Conclusions Migraine and also other primary headache disorders should be seen as particular phenotypes within a broader spectrum of symptom perception and processing disorders that require integrative diagnostics and treatment. A harmonization of classifications and better interdisciplinary collaboration are desirable.

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Section: Shared Etiopathogenesis and Pathophysiological Mechanismsmentioning

confidence: 99%

Section: S Hared E Tiopathog Ene S Is and Pathophys Iolog Ic Al Mecha...mentioning

confidence: 99%

Migraine in the context of chronic primary pain, chronic overlapping pain disorders, and functional somatic disorders: A narrative review

2022

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“…Health anxiety, illness beliefs, and symptom perception are previously studied variables that might enhance the variance explained in the linear regression models described previously. Genetic factors are known to be important but have yet to be studied concurrently with the epidemiological factors included in this study (44)(45)(46)(47).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

The Predictors of Somatic Symptoms in a Population Sample: The Lifelines Cohort Study

Creed

2022

Psychosom Med

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Objective: Multiple bodily symptoms predict poor health status, high healthcare use, and onset of functional somatic syndromes. This study aimed to identify the predictors of somatic symptoms with special reference to mental disorders. Methods: The prospective, population-based Lifelines cohort study included 80,888 adults who were followed up for a mean of 2.4 years. At baseline sociodemographic status, self-reported medical disorders, functional somatic syndromes, stress, neuroticism, mental disorders (assessed with Mini-International Neuropsychiatric Interview), health perception, and analgesic use were assessed. These variables were tested as predictors of number of somatic symptoms at follow-up using linear regression analysis, which adjusted for baseline somatic symptoms (n = 65,904). Logistic regression was used to identify the predictors of a persistently high number of somatic symptoms. Results: The strongest predictors of somatic symptoms at follow-up were life events and difficulties score, and number of general medical illnesses/functional somatic syndromes. Neuroticism and mental disorders were also independent predictors in all analyses. Generalized anxiety, major depressive, and panic disorders were all independent predictors when entered individually into the regression analysis. A persistently high number of somatic symptoms were predicted most strongly by functional somatic syndromes, negative health perception, and paracetamol use. Conclusions: Number of somatic symptoms should be regarded as a multifactorial measure with many predictors. Mental disorders form one predictor, but there are other stronger ones, including stress and general medical disorders. The bidirectional relationship between functional somatic syndromes and multiple somatic symptoms is compatible with the notion that perception of bodily symptoms is a key component of both.

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“… 1 The effects of sex and gender of patients are seen across symptoms, 2 diseases, 1 and throughout all phases of the patients’ illness trajectories. Differences between women and men are identified in the biopsychosocial etiology and persistence of somatic symptoms, 3 , 4 , 5 help-seeking behaviors, 6 medical communication about symptoms, 7 provided diagnostic interventions, 8 and efficacy of treatment. 9 …”

Section: Introductionmentioning

confidence: 99%

Gender scores in epidemiological research: methods, advantages and implications

Ballering,

Olde Hartman,

Rosmalen

2024

The Lancet Regional Health - Europe

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The association of sex, age and FKBP5 genotype with common somatic symptoms: A replication study in the lifelines cohort study

Cited by 5 publications

References 23 publications

Migraine in the context of chronic primary pain, chronic overlapping pain disorders, and functional somatic disorders: A narrative review

Migraine in the context of chronic primary pain, chronic overlapping pain disorders, and functional somatic disorders: A narrative review

The Predictors of Somatic Symptoms in a Population Sample: The Lifelines Cohort Study

Gender scores in epidemiological research: methods, advantages and implications

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