The independent relationship of epicardial adipose tissue with carotid intima-media thickness and endothelial functions

Kocaman, Sinan Altan; Durakoğlugil, Murtaza Emre; Çetin, Mustafa; Ergül, Elif; Çanğa, Aytun

doi:10.1097/mbp.0b013e32835ebbb5

Cited by 26 publications

(21 citation statements)

References 40 publications

(28 reference statements)

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“…The EFT was an independent associate in multiple logistic regression analysis. In addition, CIMT was also shown to correlate with EFT in previous studies (23, 24). As the subjects in the AI group were hormonally inactive and traditional cardiovascular risk factors were similar between groups, we can speculate that increased epicardial fat tissue may be responsible for these early cardiac and vascular changes.…”

Section: Discussionsupporting

confidence: 56%

The Relationship Between Increased Epicardial Fat Thickness and Left Ventricular Hypertrophy and Carotid Intima-Media Thickness in Patients With Nonfunctional Adrenal Incidentaloma

Imga

Elalmış

Tuna

et al. 2016

Int J Endocrinol Metab

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BackgroundEmerging evidences indicate that patients diagnosed with Adrenal Incidentaloma (AI) may present cardiovascular complications. Epicardial fat thickness (EFT) has recently been described as a new risk factor and an active player in metabolic syndrome and cardiovascular disease.ObjectivesWe aimed to evaluate the relationship between EFT and left ventricular hypertrophy and carotid intima-media thickness, which are both strong predictors of cardiovascular morbity and mortality, in patients with nonfunctioning AI.Patients and MethodsWe evaluated 51 patients (36 females and 15 males) diagnosed with AI and 35 (29 females, 6 males) age, gender and body mass index (BMI) matched healthy controls in terms of cardiovascular risk parameters. Epicardial fat was identified as the echo-free space between the outer wall of the myocardium and the visceral layer of the pericardium.ResultsEpicardial fat thickness was significantly higher in patients with AI when compared to the control group (0.89 ± 0.32 cm vs. 0.74 ± 0.26 cm; P = 0.023). left ventricular (LV) mass index and median carotid intima-media thickness (CIMT) were also higher in subjects with AI than in controls (99.8 g/m2 vs. 86.9 g/m2; P = 0.024 and 7.5 mm (5.5 - 11.5) vs. 6.5 mm (4.5 - 9.5); P = 0.017). There was a positive correlation between EFT, LV mass index, EFT and CIMT (r = 0.315, P = 0.004; r = 0.363, P < 0.001; respectively).ConclusionsIn this study we showed that EFT, measured by echocardiography is higher in subjects with AI when compared to healthy controls. epicardial fat thickness had the best independent correlation with AI in multiple logistic regression analysis. Incidentaloma is also associated with increased left ventricular mass index and CIMT. Adrenal incidentaloma patients may show early cardiac changes, such as increased left ventricular mass and increased CIMT.

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Section: Discussionsupporting

confidence: 56%

The Relationship Between Increased Epicardial Fat Thickness and Left Ventricular Hypertrophy and Carotid Intima-Media Thickness in Patients With Nonfunctional Adrenal Incidentaloma

Imga

Elalmış

Tuna

et al. 2016

Int J Endocrinol Metab

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“…In contrast, adiponectin which has antiatherogenic properties through improvement of endothelial function and anti-inflammatory effect was shown to be under expressed in EAT in patients with CAD (16). In the light of these findings, EAT is associated with metabolic syndrome (17), insulin resistance (17, 18), endothelial dysfunction, subclinical atherosclerosis (19) and overt atherosclerotic CAD (20). …”

Section: Discussionmentioning

confidence: 99%

Epicardial adipose tissue thickness is associated with myocardial infarction and impaired coronary perfusion

Tanındı¹,

Kocaman²,

Erkan³

et al. 2015

Anatol J Cardiol

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Objective:Epicardial adipose tissue (EAT) is associated with the presence, severity and extent of atherosclerotic coronary artery disease (CAD) in addition to subclinical atherosclerosis. We investigated if EAT thickness is related to acute myocardial infarction in patients with CAD. We also searched for the association between EAT thickness and objective coronary flow and myocardial perfusion parameters such as Thrombolysis in Myocardial Infarction Frame count (TFC) and myocardial blush grade (MBG).Methods:Two-hundred consecutive patients with stable angina pectoris or acute coronary syndrome who were admitted to Ufuk University Faculty of Medicine, Dr Ridvan Ege Hospital cardiology department were included in this observational, cross-sectional study. EAT thickness was evaluated by conventional transthoracic echocardiography. Coronary angiography was performed to determine the coronary involvement and perfusion.Results:Mean EAT thicknesses were 5.4±1.9 mm, 6.3±1.8 mm, and 8.5±1.4 mm in the stable angina pectoris (SAP), unstable angina pectoris (USAP) and acute myocardial infarction groups, respectively (p<0.001). With increasing EAT thickness, TFC increases whereas mean MBG values decrease (for EAT thickness <5 mm, 5-7 mm, >7 mm; mean TFC: 21.6±2.2, 25.3±3.3 and 35.2±7.7; and MBG values: 2.98±0.14, 2.83±0.57 and 1.7±1.16, respectively; both p<0.001). Cut-off EAT value to predict AMI was identified as 7.8 mm (ROC analysis AUC: 0.876; p<0.001, 95% CI: 0.822-0.927). Sensitivity and specificity of EAT cut-off value 7.8 mm to predict AMI were 81.8% and 82.5% respectively.Conclusion:Increased EAT is associated with AMI and it may prove beneficial for choosing patients who would need more aggressive approach in terms of risk reduction using echocardiography which is a relatively cheap and readily available tool as a follow-up parameter.

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“…Atherosclerosis has been identified as an inflammatory disease, 30 and it has been shown that epicardial adipose tissue is associated with 3 , 31 – 33 but not specific to atherosclerosis, as the recent literature suggests that it is also higher in patients with atrial fibrillation, heart failure, and hypertension 34 – 36 . Bachar et al 32 showed that asymptomatic patients with coronary artery disease (CAD) have significantly more epicardial adipose tissue than patients without CAD.…”

Section: Discussionmentioning

confidence: 99%

Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behçet Disease

Taşolar

Kurtulus

et al. 2014

J of Ultrasound Medicine

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The independent relationship of epicardial adipose tissue with carotid intima-media thickness and endothelial functions

Abstract: Our study showed that EAT is an independent factor of adverse changes in CIMT, FMD, and PWV. Future studies, investigating the vascular influence of EAT at the molecular level, may provide therapeutic options to prevent its adverse vascular interactions.

Cited by 26 publications

References 40 publications

The Relationship Between Increased Epicardial Fat Thickness and Left Ventricular Hypertrophy and Carotid Intima-Media Thickness in Patients With Nonfunctional Adrenal Incidentaloma

The Relationship Between Increased Epicardial Fat Thickness and Left Ventricular Hypertrophy and Carotid Intima-Media Thickness in Patients With Nonfunctional Adrenal Incidentaloma

Epicardial adipose tissue thickness is associated with myocardial infarction and impaired coronary perfusion

Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behçet Disease

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