Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behçet Disease

Taşolar, Hakan; Taşolar, Sevgi; Kurtulus, Duygu; Altun, Burak; Bayramoğlu, Adil; Otlu, Yılmaz Ömür; Ballı, Mehmet; Çetın, Mustafa; Altunışık, Nihal; Kapıcıoğlu, Yelda; Pekdemir, Haşan

doi:10.7863/ultra.33.8.1393

Cited by 9 publications

(13 citation statements)

References 35 publications

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“…Carotid intima media thickness, endothelial dysfunction, MPV and EAT thickness are some parameters that suggested for evaluation of increased atherosclerotic risk [3-5,7]. Familial Mediterranean fever is an inflammatory disease suggested to predispose to atherosclerosis [4-6].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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BackgroundFamilial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls.MethodsForty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography.ResultsEpicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV).ConclusionEpicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.

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Section: Discussionmentioning

confidence: 99%

“…[7,8,22]. Studies evaluating carotid intima media thickness and endothelial dysfunction in FMF patients have found an increased risk of atherosclerosis [4,5].…”

Section: Discussionmentioning

confidence: 99%

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

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“…Epicardial adipose tissue appeared as an anechoic space between the epicardial layers on B‐mode images. The epicardial adipose tissue thickness (EATT) was measured as the vertical distance of the space on the free wall of the right ventricle in the parasternal long‐axis view at end diastole …”

Section: Methodsmentioning

confidence: 99%

“…The epicardial adipose tissue thickness (EATT) was measured as the vertical distance of the space on the free wall of the right ventricle in the parasternal long-axis view at end diastole. 11 In the 3DSTE study, a fully sampled matrix-array probe (GE 4V-D) was used to acquire LV full-volume images(frame rate = 25~45 frames/s). These images were stitched in 6 subvolumes in 6 consecutive cycles, including three tomographic orientations at the apex (four-chamber, three-chamber, and two-chamber) and three short-axis sections (basal, middle, and apical).…”

Section: Echocardiography Measurementsmentioning

confidence: 99%

Left ventricular structural alterations are accompanied by subclinical systolic dysfunction in type 2 diabetes mellitus patients with concomitant hyperlipidemia: An analysis based on 3D speckle tracking echocardiography

et al. 2018

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“…Fat tissue developing in the epicardial area is a marker of this systemic response and can function as a lipidstorage depot, as an endocrine organ that secretes hormones, and as inflammatory tissue that secretes cytokines and chemokines (10). Various studies have shown EFT to increase in systemic inflammatory diseases such as RA (6), SLE (7), and Behçet's disease (27). There are very few studies in the literature investigating the association of COPD and EFT.…”

Section: Discussionmentioning

confidence: 99%

Relationship between metabolic syndrome and epicardial fat tissue thickness in patients with chronic obstructive pulmonary disease

Demir¹

2016

Anatol J Cardiol

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Relationship between metabolic syndrome and epicardial fat tissue thickness in patients with chronic obstructive pulmonary disease Objective: An increase in epicardial fat tissue (EFT) thickness was found to be associated with metabolic syndrome (MS) and ischemic heart disease. MS is a comorbidity of chronic obstructive pulmonary disease (COPD) resulting from the accompanying systemic inflammation. The aim of our study was to investigate the usefulness of EFT thickness to predict MS in COPD patients. Methods: COPD patients admitted to our clinic during January-December 2014 and healthy controls were included in this prospective casecontrol study. Patients with comorbidities, COPD exacerbation, and malignancies were excluded. Patients and controls were compared in terms of anthropometric measurements, MS-related examination and laboratory findings, pulmonary function tests, and EFT thickness. The correlations between EFT thickness and markers of MS in COPD were evaluated using the Student's t-test and logistic regression analysis. Results: COPD patients and controls were composed of 82 and 84 individuals, respectively. MS was diagnosed in 31 (37.8%) COPD patients. The EFT thickness was significantly higher in COPD patients than in the controls and was also higher in COPD patients with MS than in those without MS (all p<0.001). Each 1-mm increment of EFT raised the risk of MS twofold (p=0.011, OR=2.08, 95% CI: 1.18-3.68). Increase in triglyceride level (p=0.004, OR=1.02, 95% CI: 1.01-1.03) and reduction in forced vital capacity (p=0.025, OR=0.26, 95% CI: 0.08-0.84) were found to be associated with increased MS risk. The cutoff value for EFT thickness in the prediction of MS in COPD patients was 6.75 mm (sensitivity: 83%, specificity: 65%). Conclusion: EFT thickness is a non-invasive and easily available parameter, which is valuable in the prediction of increased MS risk in COPD patients. Early diagnosis of patients at risk of MS may help to prevent ischemic heart disease in these patients.

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Increased Epicardial Adipose Tissue Thickness on Transthoracic Echocardiography in Patients With Behçet Disease

Cited by 9 publications

References 35 publications

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Left ventricular structural alterations are accompanied by subclinical systolic dysfunction in type 2 diabetes mellitus patients with concomitant hyperlipidemia: An analysis based on 3D speckle tracking echocardiography

Relationship between metabolic syndrome and epicardial fat tissue thickness in patients with chronic obstructive pulmonary disease

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