The increase of mean platelet volume in patients with Alzheimer disease

Koç, Emine Rabia; Uzar, Ertuğrul; Çirak, Yasemin; Demir, Yasemin Parlak; İlhan, Atilla

doi:10.3906/sag-1212-5

Cited by 15 publications

(17 citation statements)

References 33 publications

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“…Chen et al (2017), comparing the routine blood parameters of 92 patients with AD and 84 healthy controls, determined that MPV levels were significantly elevated in AD patients. Koc et al (2014) found that MPV levels were significantly elevated in AD patients and were associated with cognitive impairment severity. In our study, we also confirmed that the MPV was higher in MCI patients and had an optimal diagnostic value in distinguishing MCI patients from healthy controls.…”

Section: Discussionmentioning

confidence: 93%

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Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer’s Disease

Dong

Nao

Shi

et al. 2019

Front. Aging Neurosci.

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BackgroundBiomarker screening is of major significance for the early diagnosis and prevention of Alzheimer’s disease (AD). Routine peripheral blood parameters are easy to collect and detect, making them ideal potential biomarkers. Thus, we aimed to evaluate the parameters from routine blood as potential biomarkers for AD.MethodsWe enrolled 56 AD patients, 57 mild cognitive impairment (MCI) patients, and 59 healthy elderly controls. Receiver operating characteristic (ROC) curves were used to assess the diagnostic values of routine blood biomarkers in patients with cognitive impairment.ResultsThere were significant differences in eight parameters between the groups. Logistic regression revealed that the neutrophil% (odds ratio (OR) 1.34, 95% confidence interval [CI] 1.03–1.75, p = 0.031) and neutrophil-to-lymphocyte ratio (NLR; OR 6.27, 95% CI 3.98–9.82, p = 0.003) differentiated AD patients and controls (areas under the curve [AUCs], 0.728 and 0.721) and that the NLR (OR 1.93, 95% CI 1.07–3.47, p = 0.028) and mean platelet volume (OR 1.67, 95% CI 1.04–2.70, p = 0.036) differentiated MCI patients and controls (AUCs, 0.60 and 0.638). There were no effective diagnostic biomarkers to distinguish AD from MCI.ConclusionSome routine blood biomarkers may correlate with cognitive impairment. Analysis of these biomarkers, such as the NLR, may be useful for the identification of patients with cognitive impairment.

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Section: Discussionmentioning

confidence: 93%

“…MPV is a determining factor of platelet function, and an elevated MPV is correlated with vascular inflammation. Koc et al (2014) reported that MPV levels were higher in AD patients. Yesil et al (2012) also considered that an increased MPV was associated with vascular risk in AD.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer’s Disease

Dong

Nao

Shi

et al. 2019

Front. Aging Neurosci.

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“…Liang et al reported significantly reduced MPV levels as cognitive levels declined and showed that MPV levels were significantly associated with MMSE (33) . Koç et al reported elevated MPV levels in patients with Alzheimer's disease but in that study when the patients were divided into 2 subgroups as having mild or moderate cognitive impairments according to MMSE scores, there was not any statistically significant difference between moderate and the mild groups regarding MPV values (15) . We also could not determine an association between serum MPV levels and cognitive functions.…”

Section: Discussionmentioning

confidence: 73%

“…Mean platelet volume (MPV) is a marker of activated platelets and has been associated with many inflammatory conditions (12)(13)(14). On the other hand, elevated MPV levels were also reported in patients with Alzheimer disease having cognitive impairments (15) .…”

Section: Introductionmentioning

confidence: 99%

The Relation of Uric Acid And MPV Levels And Cognitive Functions In Fibromyalgia

Vural¹,

Aydın²,

Çakmak³

et al. 2020

BMJ

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Objective: Patients with fibromyalgia syndrome (FMS) have mild cognitive dysfunction. Higher serum uric acid (UA) levels in some diseases are reported to be associated with cognitive impairment. Mean platelet volume (MPV) is an indicator of platelet activation. Activated platelets may play a role in neuroinflammation and cognitive dysfunction. The purpose of this study was to compare cognitive functions of FMS patients and controls and investigate the relation of serum UA and MPV levels with cognitive functions. Method: Fifty-four patients with FMS and 33 healthy controls were enrolled,retrospectively. Evaluations were performed with Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory(BDI) and to asses phychological status and cognitive impairment Mini Mental State Examination(MMSE) was used in both groups. Results: Mean VAS and sleep quality of FMS group were significantly higher than the control group (p<0.05). Mean MMSE score was statistically significantly lower in the FMS group (p=0.0001). There was not statistically significant correlation between serum UA levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05). No significant correlation was found between serum MPV levels and VAS pain/ sleep quality, FIQ, BDI and MMSE scores (p>0.05) but declined cognitive functions were determined in the FMS group when compared with the control group. Conclusion: Declined cognitive functions were determined in the FMS the FMS group when compared with the control group. Although we did not determine an association of serum uric acid and MPV levels with cognitive functions, larger prospective studies with longer follow up periods are warranted to elucidate the role of these biomarkers in FMS and to determine the factors affecting cognitive functions.

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“…Platelet activity can be assessed by simple platelet parameters such as platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) routinely obtained during analysis of peripheral blood morphology [12][13][14]. Recent studies showed contradictory results concerning the relationship between MPV and cognitive performance [15][16][17][18][19]. Therefore, the aim of the study was to evaluate the relationship between basic platelet indices (PI) and the cognitive and functional performance of older patients admitted to the hospital ward.…”

Section: Introductionmentioning

confidence: 99%

The association between platelet indices, cognitive screening tests and functional dependence screening questionnaires in hospitalized older people

et al. 2019

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Aim To investigate whether the cognitive or functional status is related to basic platelet indices in hospitalized older adults. Findings After adjustment for multiple confounders, the Mini-Mental State Examination Scale, the seven-point Clock Drawing Test, the Katz ADL scale, the Lawton IADL scale and VES-13 are, except one weak association, not directly related to basic platelet indices measured in the routine complete blood count. Message The basic platelet indices measured in the routine complete blood count are not consistently associated with the cognitive and functional status evaluated by screening tests. The lack of translation of these associations in clinical use could be due to the multifaceted effect of diseases other than dementia.

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The increase of mean platelet volume in patients with Alzheimer disease

Cited by 15 publications

References 33 publications

Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer’s Disease

Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer’s Disease

The Relation of Uric Acid And MPV Levels And Cognitive Functions In Fibromyalgia

The association between platelet indices, cognitive screening tests and functional dependence screening questionnaires in hospitalized older people

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