The Incidence of Senile Cataract and Glaucoma is Increased in Patients with Plasma Cell Dyscrasias: Etiologic Implications

Hemminki, Kari; Försti, Asta; Tuuminen, Raimo; Hemminki, Otto; Goldschmidt, Hartmut; Sundquist, Kristina; Sundquist, Jan; Li, Xinjun

doi:10.1038/srep28500

Cited by 15 publications

(10 citation statements)

References 35 publications

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“…Assessment of eye structures also enables the prevention of severe eye complications 10 . This detection can also reveal the incidence of plasma cell dyscrasia, for instance, which can be an etiological factor in senile cataract and glaucoma 11 .…”

Section: Discussionmentioning

confidence: 99%

Comparing Interrater reliability between eye examination and eye self-examination

Lima

Pagliuca²,

Nascimento³

et al. 2017

Rev. Latino-Am. Enfermagem

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ResumeObjective:to compare Interrater reliability concerning two eye assessment methods. Method:quasi-experimental study conducted with 324 college students including eye self-examination and eye assessment performed by the researchers in a public university. Kappa coefficient was used to verify agreement. Results:reliability coefficients between Interraters ranged from 0.85 to 0.95, with statistical significance at 0.05. The exams to check for near acuity and peripheral vision presented a reasonable kappa >0.2. The remaining coefficients were higher, ranging from very to totally reliable. Conclusion:comparatively, the results of both methods were similar. The virtual manual on eye self-examination can be used to screen for eye conditions.

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Section: Discussionmentioning

confidence: 99%

Comparing Interrater reliability between eye examination and eye self-examination

Lima

Pagliuca²,

Nascimento³

et al. 2017

Rev. Latino-Am. Enfermagem

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“…The authors attributed this discovery to the deposition of M-protein and light chains in the eye lens, a tissue with a greater protein concentration than other tissues. This environment may promote protein aggregation, resulting in opacification of the ocular lens and restriction of humoral outflow in the iridocorneal angle [15].…”

Section: Discussionmentioning

confidence: 99%

Ocular Manifestations in Hematological Disorders

Bahaj¹,

Youssefi²,

Bouanani³

2022

Cureus

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BackgroundOphthalmic manifestations are a common feature in hematological malignancies and may be divided into two groups: those attributable to the disease's infiltration of the eye, and the ocular consequences due to blood abnormalities. This study aims to determine the prevalence of ocular manifestations and their association with the different hematological disease subgroups. Materials and methodsWe conducted a retrospective and observational study enrolling 137 consecutive patients on active treatment or follow-up for hematological malignancies from January 2016 to January 2020 at the Cheikh Khalifa International University Hospital. All patients underwent a standardized and comprehensive ophthalmic evaluation. ResultsOcular involvement was primarily disclosed in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma (MM). We herein report the different ocular changes divided into anterior segment manifestations, posterior segment manifestations, dry eye disease, and ocular adnexa findings. Patients with leukemia had a significantly higher rate of lesions in the ocular posterior segment (p < 0.001). Despite the high prevalence of anterior segment and ocular adnexa findings in lymphoma patients, no significant association emerged between these lesions and the aforementioned condition. In addition, dry eye disease was found in all instances without any association with the disease itself. ConclusionsAwareness of ocular pathology in hematological malignancies is important as it may precede systemic diagnosis or be a sign of recurrence. We should also be concerned about the side effects of treatments, predominantly, dry eye disease. Therefore, periodic ophthalmic assessment throughout the disease's course, as well as interdisciplinary coordination of care, is crucial to promote early diagnosis and treatment, hence improving long-term outcomes.

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“…Az időskori szürkehályog megjelenésének kockázatát valamivel magasabbnak írták le AL amyloidosisban, mint egyéb gammopathiákban. A glaucoma megjelenésének kockázata nem különbözött MGUS-ban, Waldenström-macroglobulinaemiában és könnyűlánc AL amyloidosisban, és myeloma multiplex nem növelte a glaucoma kialakulásának kockázatát [18].…”

Section: Időskori Szürkehályog éS Zöldhályogunclassified

Szemészeti tünetek és szemészeti társbetegségek monoklonális gammopathiával járó kórképekben

Szentmáry

Kormányos

Tóth

et al. 2021

Hematológia–Transzfuziológia

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Összefoglaló. Célkitűzés: A monoklonális fehérjetermeléssel járó haematológiai kórképek szemészeti tüneteinek és szemészeti társbetegségeinek összefoglalása irodalmi adatok alapján. Módszer: A Pubmedben rendelkezésre álló adatok kigyűjtése, elemzése és összefoglalása. Eredmények: Immunglobulin-lerakódás a szem szövetei közül leggyakrabban a szaruhártyában figyelhető meg (paraproteinaemiás vagy immuntaktoid keratopathia). A monoklonális fehérjeszaporulattal járó plazmasejtes betegség gyakoribb szemészeti jelei pedig a paraproteinaemiás keratopathia mellett a kristályhordozó histiocytosis (CSH), a hypercupremiás keratopathia, a foveolaris drusen/maculopathia és az orbitalis plasmocytoma. A ritkább szemészeti jelek/tünetek közé az akut/krónikus uveitis, a Doyne retina dystrophia és az arteria vagy vena centralis retinae elzáródása tartoznak. Szemészeti mellékhatás szisztémás szteroidok és a belantamab mafotidin alkalmazásakor jelentkeznek. Következtetések: A monoklonális gammopathiával járó kórképek sokszínű szemészeti panaszokkal jelentkezhetnek a klinikai gyakorlatban, aminek felismerése a megfelelő kivizsgálás elindításával a szemész feladata. A betegek kezelése és gondozása során a haematológusok és szemészek együttműködése a számos ismert szemészeti tünet és társbetegség miatt elengedhetetlen. A megfelelő szemészeti kezeléssel a látóélesség és ezáltal a betegek életminősége jelentősen javítható. Summary. Purpose: To summarize ocular symptoms and ocular comorbidities of monoclonal gammopathy, based on literature data. Methods: A comprehensive Pubmed search has been performed to summarize ocular symptoms and comorbidities before January 2021. Results: Immunglobulin deposition was most commonly observed in the corneal tissue (paraproteinaemic or immuntactoid keratopathy). Beside paraproteinaemic keratopathy, the most common ocular signs and ocular comorbidities of plasma cell disorders with monoclonal gammopathy are crystal-storage histiocytosis (CSH), hypercupremic keratopathy, foveolar drusen/maculopathy and orbital plasmocytoma. Less common ocular signs are acute/chronic uveitis, Doyne retinal dystrophy, central retinal artery or vein occlusion. Ophthalmic side effects are expected following the use of systemic steroids or belantamab mafotidin. Conclusions: Monoclonal gammopathy may present with diverse ocular symptoms in the clinical practice, which should be examined and treated through an ophthalmologist. Therefore, collaboration of haematologists and ophthalmologists is essential for these patients. With appropriate ophthalmic treatment, there is a significant improvement of best corrected visual acuity of these patients, with a significant impact on their quality of life.

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The Incidence of Senile Cataract and Glaucoma is Increased in Patients with Plasma Cell Dyscrasias: Etiologic Implications

Cited by 15 publications

References 35 publications

Comparing Interrater reliability between eye examination and eye self-examination

Comparing Interrater reliability between eye examination and eye self-examination

Ocular Manifestations in Hematological Disorders

Szemészeti tünetek és szemészeti társbetegségek monoklonális gammopathiával járó kórképekben

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