The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy

Hou, Chun‐Han; Hou, Sheng‐Mou; Hsueh, Yu-Sheng; Lin, Jinn; Wu, Hsi‐Chin; Lin, Fa‐Hsuan

doi:10.1016/j.biomaterials.2009.04.020

Cited by 234 publications

(133 citation statements)

References 34 publications

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“…For instance, silicon-doped HA has been found to be able to promote rapid bone mineralization [6,13]. Recently, some complex composites containing HA have been designed to induce bone cancer cell apoptosis by magnetic hyperthermal therapy [14][15][16]. Meanwhile, these materials possess good biocompatibility and support bone regeneration [15,16].…”

Section: Introductionmentioning

confidence: 99%

Dual functional selenium-substituted hydroxyapatite

Wang

Zhou

et al. 2012

Interface Focus.

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Hydroxyapatite (HA) doped with trace elements has attracted much attention recently owing to its excellent biological functions. Herein, we use a facile co-precipitation method to incorporate selenium into HA by adding sodium selenite during synthesis. The obtained selenium-substituted HA products are needle-like nanoparticles which have size and crystallinity that are similar to those of the pure HA nanoparticles (HANs) when the selenium content is low. HANs are found to have the ability to induce the apoptosis of osteosarcoma cells, and the anti-tumour effects are enhanced after incorporation of selenium. Meanwhile, the nanoparticles can also support the growth of bone marrow stem cells. Furthermore, the flow cytometric results indicate that the apoptosis induction of osteosarcoma cells is caused by the increased reactive oxygen species and decreased mitochondrial membrane potential. These results show that the selenium-substituted HANs are potentially promising bone graft materials in osteosarcoma treatment due to their dual functions of supporting normal cell growth and inducing tumour cell apoptosis.

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Section: Introductionmentioning

confidence: 99%

Dual functional selenium-substituted hydroxyapatite

Wang

Zhou

et al. 2012

Interface Focus.

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“…Hou et al followed the similar pathway of Wu et al for synthesizing MHAp nanoparticles in an in vivo hyperthermia study with the mice model. 69 Laranjeira et al prepared MHAp nanoparticles doped with different magnetic dopants (Gd, Co, and Fe) by wet precipitation method. First, they used calcium hydroxide as the calcium precursor and then added gadolinium chloride hexahydrate, cobalt nitrate hexahydrate, iron nitrate nonahydrate, and iron chloride tetrahydrate (2.5%-10%) to phosphoric acid at pH 7.4 with stirring for 2 h and overnight aging.…”

Section: Different Synthesis Routes Of Magnetic Hapmentioning

confidence: 99%

“…The blood cytotoxicity study of the mouse showed that MHAp nanoparticles have good biocompatibility with very less toxicity when subcutaneously injected. 69 Kamitakahara et al successfully synthesized spherical HAp granules that contained composites of magnetic and HAp nanoparticles via a hydrothermal process. 104 The obtained composite nanoparticles were expected to generate enough heat to kill cancer cells under an alternating magnetic field.…”

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confidence: 99%

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

Mondal¹,

Manivasagan²,

Bharathiraja³

et al. 2017

IJN

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In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications.

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“…We have focused on MR thermometry, photoacuastic mapping of different tumor locations. Recent improvements in optical imaging techniques now allow these microdomains to be visualized such as single channel calcium fluorescence transients (SCCaFTs), providing information about channel properties to monitor the activity and localization of microdomain calcium complexes [146]. Other emerging possibilities are MR thermal mapping by gadolinium-ferrite complexed with Zn or Co or perfluorocarbons, integrins, fibrins, and monoclonal antibody labeled nanoparticles [147,148].…”

Section: Nanoparticles In Hyperthermia Monitoring By Protein Targetedmentioning

confidence: 99%

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

Sharma¹,

Sharma²,

Chen³

2011

TONMJ

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Abstract:Heating tumors by nanoparticles and resistance in tumor cells to a high temperature is emerging as an effective tool as nanomedicine tool in cancer therapy. The art of thermal mapping in a tumor at various locations is emerging as the selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures but show cytotoxicity. The design and application of 10-100 nano meter sized nanoparticles in tumor hyperthermia has emerged as an effective technology in hyperthermia imaging and treatment. The temperature and nanoparticle magnetic moment relationship is specific. Furthermore, there are two main issues that are unsolved as of yet. First issue is the relationship of tumor energy changes due to tumor magnetization by different nanoparticles. The second issue is the heat transfer behavior of the nanoparticle inside the tumor combined with hyperthermia and efficacy of combined modality on the tumor tissue temperature rise. In present study, we highlight that in vivo imaging such as MR thermometry, photoacuastic mapping of different tumor locations solve these issues to some extent. The art of combined use of hyperthermia by nanoparticles with hypoxia sensitive nitroimidazole radiosensitizers with chemotherapeutic drugs is highlighted to have a great impact on public health as alternative therapeutic oncology and monitoring therapy.

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The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy

Cited by 234 publications

References 34 publications

Dual functional selenium-substituted hydroxyapatite

Dual functional selenium-substituted hydroxyapatite

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

State of Art on Bioimaging by Nanoparticles in Hyperthermia and Thermometry: Visualization of Tissue Protein Targeting

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