Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

Mondal, Sudip; Manivasagan, Panchanathan; Bharathiraja, Subramaniyan; Moorthy, Madhappan Santha; Kim, Hye Hyun; Seo, Hansu; Lee, Kang Dae; Oh, Junghwan

doi:10.2147/ijn.s147355

Cited by 87 publications

(42 citation statements)

References 96 publications

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“…The hydrothermal process was used for the synthesis of the magnetic nanocomposite according to the previous report [ 20 , 21 ]. Typically, 0.01 M of (NH 4 ) 2 HPO 4 and 0.1 M of CTAB was dissolved in distilled water at room temperature with continuous stirring.…”

Section: Methodsmentioning

confidence: 99%

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

Kermanian

Naghibi

Sadighian

2020

Heliyon

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Synthetic hydroxyapatite (HA) due to its high biocompatibility, anti-inflammatory properties, high stability, and a flexible structure in combination with magnetic nanoparticles has the strong potential to be used in modern medicine including tissue engineering, imaging, and drug delivery. Herein, a hydrothermal process was used to prepare magnetite nanoparticles dispersed on the hydroxyapatite nanorods with cetyltrimethylammonium bromide (CTAB) as a surfactant. Characterization study of the synthesized iron oxide-hydroxyapatite (IO-HA) nanocomposite was performed by FT-IR spectroscopy, X-ray powder diffraction, energy dispersive X-Ray analysis (EDX) for elemental mapping, transmission electron microscopy, and vibrating sample magnetometer. Then, the biocompatibility of the synthesized nanocomposite studied by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay and hemocompatibility assay. Focus on this point, curcumin loaded IO-HA (Cur@IO-HA) was developed for exploring the pH-sensitivity of the drug carrier and then evaluating its cellular uptake. The in vitro efficacy of the synthesized nanocomposites as a magnetic resonance imaging (MRI) contrast agent was also investigated. Our results showed that IO-HA nanocomposite is non-cytotoxic and hemocompatible as well as a good pH-sensitive drug carrier and a favorable MRI T2 contrast agent. Comparing to the free curcumin, Cur@IO-HA displayed a good cellular uptake. Taking into account the above issues, IO-HA nanocomposite has the most potential for application as a theranostic MRI contrast agent.

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Section: Methodsmentioning

confidence: 99%

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

Kermanian

Naghibi

Sadighian

2020

Heliyon

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“…Gadolinium (Gd), dysprosium (Dy), and neodymium (Nd) -substituted HA composites have been widely used for such a purpose in magnetic resonance imaging (MRI) [392,400]. It is worth mentioning also that paramagnetic elements play an important role in multimodal imaging as contrast agents [392].…”

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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“…Further studies are needed to investigate the effect of this construct in an orthotopic bone defect model and in combination with other hard supporting materials (e.g., HAP). Although a previous review has focused on the multifunction of magnetic HAP in nanomedicine application (Mondal et al, 2017), the characteristics involved in the magnetic PEG hydrogels should be tested comprehensively.…”

Section: Applications In Bone Tissue Engineeringmentioning

confidence: 99%

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

et al. 2020

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Tissue engineering is a promising strategy for the repair and regeneration of damaged tissues or organs. Biomaterials are one of the most important components in tissue engineering. Recently, magnetic hydrogels, which are fabricated using iron oxide-based particles and different types of hydrogel matrices, are becoming more and more attractive in biomedical applications by taking advantage of their biocompatibility, controlled architectures, and smart response to magnetic field remotely. In this literature review, the aim is to summarize the current development of magnetically sensitive smart hydrogels in tissue engineering, which is of great importance but has not yet been comprehensively viewed.

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Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

Cited by 87 publications

References 96 publications

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

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