One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

Kermanian, Mehraneh; Naghibi, Mehran; Sadighian, Somayeh

doi:10.1016/j.heliyon.2020.e04928

Cited by 36 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rod-shaped structure of the apatitic material can be noticed, as presented by our group [6,13] and other authors for metal-substituted hydroxyapatite [38], as well as the presence of the smaller, quasi-spherical magnetic phase. The overall morphology of the composite is similar to the one reported by Kermanian et al [39] for magnetite nanoparticles dispersed on hydroxyapatite nanorods. Given the identified morphologies on the TEM images, it is most likely that the pararobertsite phase also has a rod-shaped structure, but this aspect remains to be fully elucidated.…”

Section: Analytical Characterization Of the Materialssupporting

confidence: 84%

Iron Oxide/Phosphatic Materials Composites with Potential Applications in Environmental Protection

et al. 2020

View full text Add to dashboard Cite

Currently, hydroxyapatite is probably the most researched material, due to its multiple applications in medical, environmental, or cultural heritage, when the classical structure is modified and calcium is displaced partially or totally with different metals. By changing the classical structure of the hydroxyapatite, new morphologies can be obtained, thus allowing final applications different from those of the initial hydroxyapatite material. However, their properties should be tuned for the desired application. In this context, the present paper describes the synthesis and characterization (through energy-dispersive X-ray fluorescence, X-ray diffraction, FTIR, thermal analysis, and transmission electron microscopy) of iron oxide/manganese-containing phosphatic phase composite materials, developed in order to obtain the enhancement of final environmental applications (photodegradation of dyes, adsorption of organic compounds). The composite material was tested for photocatalytic properties, after embedding in hydrosoluble film-forming materials. Photocatalytic coatings show different activity during the photodecomposition of Methylene Blue, used as a model of a contaminant. The photocatalytic activities of the materials were discussed in relationship with both the phosphatic materials and the magnetic components. Finally, other environmental applications were studied for the developed materials (adsorption of non-steroidal anti-inflammatory drugs—paracetamol and ibuprofen), revealing an enhancement of the adsorption capacity of the phosphatic material upon addition of the magnetic phase.

show abstract

Section: Analytical Characterization Of the Materialssupporting

confidence: 84%

Iron Oxide/Phosphatic Materials Composites with Potential Applications in Environmental Protection

et al. 2020

View full text Add to dashboard Cite

show abstract

“… 48 The discovery of novel agents which sensitize malignant cells to the effect of radiation would increase tumor response by slowing dividing tumors sensitive to irradiation while minimizing toxicity to the surrounding organs by lowering the effective therapeutic dose. 49 , 50 In this regard, the role of QMNPs to enhance the radiosensitivity of MCF-7 cancer cells was evaluated. The current data of the in vitro study revealed that QMNPs enhanced the suppression of MCF-7 cancer cells proliferation as examined qualitatively by MTT assay and inverted light microscope, compared with the sole RT treatment alone.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer

Askar

El-Nashar

Al-Azzawi

et al. 2022

Breast Cancer�(Auckl)

View full text Add to dashboard Cite

Quercetin is a potent cancer therapeutic agent present in fruits and vegetables. The pharmaceutical uses of quercetin are limited due to many problems associated with low solubility, bioavailability, permeability, and instability. In addition, the high doses of quercetin show toxic effects in clinical and experimental studies. Therefore, a new strategy is warranted to overcome these problems without the use of toxic doses. The iron oxide nanoparticles can be used as a drug delivery system. This study aimed to prepare quercetin-conjugated magnetite nanoparticles (QMNPs) using biological simple nanoprecipitation and mediated by fungus Aspergillus oryzae. Also, we initiated in vitro and in vivo studies to determine whether QMNPs might sensitize breast cancer to radiotherapy treatment. The structural, morphological, and magnetic properties of the prepared nanoparticles were studied. The results indicated that QMNPs were spherical in shape and 40 nm in diameter. The in vitro studies showed that the incubation of MCF-7, HePG-2, and A459 cancer cells with QMNPs for 24 h effectively inhibited the growth of cancer cell lines in a concentration-dependent manner with IC50 values of 11, 77.5, and104 nmol/mL, respectively. The combination of QMNPs with irradiation (IR) potently blocked MCF-7 cancer cell proliferation and showed significant changes in the morphology of these cells as observed by bright-field inverted light microscopy. Focusing on the long-term toxicity of QMNPs (20 ml/kg), the assessment of hematological, hepatic, and renal markers indicated no toxic effect. Besides, QMNPs inhibited tumor growth and potently enhanced the lateral radiotherapy treatment in N-methyl-N-nitrosourea (MNU)-induced breast cancer in female white albino rats. These anticancer and radiosensitizing activities were ascribed to cytotoxicity, cell cycle arrest, immunomodulation, and efficiency through induction of apoptosis. In a conclusion, these observations suggest that the QMNPs combined with LRT could act as a potential targeted therapy in breast cancer.

show abstract

“…Although the magnetic nanoparticles have low toxicity and their biologically compatible (Yang, Gong, and Zhang, 2010), the aggregation process makes magnetite nanoparticles difficult to internalized to plant cell (Dağlioğlu and Yilmaz, 2018). Hydroxyapatite particles is the best inorganic auxiliary material that prevent aggregation of Fe 3 O 4 (Kermanian, Naghibi, and Sadighian, 2020). However, the chlorophyll content of aged leaves treated with magnetite-hydroxyapatite nanocomposite have shown an opposite tendency compared to treated with magnetite nanoparticles.…”

Section: Chlorophyll Content Of Wheatmentioning

confidence: 99%

The Ecotoxicological Evaluations of Fe3O4, HAp, and Fe3O4-HAp Nanocomposite on Wheat: Impact on Chlorophyll Content

DOĞAROĞLU

Uysal

2022

Kahramanmaraş Sütçü İmam Üniversitesi Mühendislik Bilimleri Dergisi

View full text Add to dashboard Cite

Nanoparticles have an increasing accumulation and effect as day to day in aquatic, terrestrial and atmospheric environments, and one of the most basic factors determining these effects is their sizes. As the material size decreases, the distribution and accumulation of particles are facilitated and accelerated. In this study, the possible nanotoxicological effects of nanomagnetite (Fe 3 O 4 NPs), hydroxyapatite (HAp) (synthesized by the recovery of waste eggshells) and Fe 3 O 4 -HAp nanocomposite on wheat germination percentage and chlorophyll production were evaluated. It was determined with SEM images that the Fe 3 O 4 nanoparticles was in the size of 22-30 nm, while the Fe 3 O 4 -HAp was 90-350 nm. The presence of HAp particles caused a decreasing in the germination percentage compared to presence of only Fe 3 O 4 nanoparticles, as like in the root elongation (20-27%). The chlorophyll content was determined in the both aged and young leaves on second, third and fourth weeks of wheat plants. Results showed that wheat plants were sensitive in the early stage of plant growth (second week) to the all test chemicals. The presence of HAp in the growth media decreased the chlorophyll content of wheat because of their sizes. The maximum decreasing of chlorophyll content in wheat was observed at the 40 mg L -1 HAp treatment as 86%. All the test chemicals used in this study uses in many areas, thus it should be detailed evaluated ecotoxicological aspect.

show abstract

One-pot hydrothermal synthesis of a magnetic hydroxyapatite nanocomposite for MR imaging and pH-Sensitive drug delivery applications

Cited by 36 publications

References 27 publications

Iron Oxide/Phosphatic Materials Composites with Potential Applications in Environmental Protection

Iron Oxide/Phosphatic Materials Composites with Potential Applications in Environmental Protection

Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer

The Ecotoxicological Evaluations of Fe3O4, HAp, and Fe3O4-HAp Nanocomposite on Wheat: Impact on Chlorophyll Content

Contact Info

Product

Resources

About