The Importance of In Vivo Metabolism of Polyphenols and Their Biological Actions

Barnes, Stephen; D'Alessandro, Tracy; Kirk, M; Patel, Rachana; Boersma, Brenda J.; Darley‐Usmar, Victor; Meskin, M. S.; Bidlack, Wayne R.; Davies, A. J.; Lewis, D. S.; Randolph, Ryan

doi:10.1201/9780203506332.ch4

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…Перспективни-ми препаратами вважаються поліфенольні спо-луки рослинного походження, в яких побічна токсична дія на організм відсутня. Із літератури відомо, що природний поліфенольний ком-плекс винограду, зокрема виноградного вина, виявляє антиоксидантні та детоксикаційні властивості [12]. Особливість хімічної будо-ви поліфенольних сполук обумовлює їхню здатність нейтралізувати вільні радикали і про-дукти ліпопероксидації біомембран, чим вони запобігають продовженню патологічних лан-цюгових реакцій [6,13].…”

Section: досліджено сумарну активність No-синтази та вміст стабільнихunclassified

“…Окрім того, кверце-тин та галова кислота регулюють активність цього ензиму підвищенням концентрації Ca 2+ через вивільнення в цитоплазму із внутрішньоклітинних депо або рецепторзалеж-ним механізмом, ключовою подією якого є зро-стання активності гуанілатциклази. Внаслідок цього зростає активність кальційзалежних ізоформ NOS, підвищується продукуван-ня NO і відповідно змінюється оксидативно-нітративний стан клітин [12,[22][23][24].…”

Section: вміст стабільних метаболітів оксиду азоту в периферичній кроunclassified

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The effect of natural polyphenol complex of red grape wine ON L-arginine/NO system

Sabadashka¹

2014

Ukr.Biochem.J.

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Section: досліджено сумарну активність No-синтази та вміст стабільнихunclassified

Section: вміст стабільних метаболітів оксиду азоту в периферичній кроunclassified

The effect of natural polyphenol complex of red grape wine ON L-arginine/NO system

Sabadashka¹

2014

Ukr.Biochem.J.

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“…Priyadarsini et al, (2003) menyatakan bahwa atom H dari senyawa fenolik sangat potensial sebagai aktivitas antioksidan. Banyak senyawa fenolik diketahui potensial dalam aktivitas antioksidan serta beberapa di antaranya berperan untuk inhibitor melanogenesis (Barnes et al, 2004;Han et al, 2007).…”

Section: Pengantarunclassified

Efektivitas Kurkumin Sebagai Antioksidan Dan Inhibitor Melanin Pada Kultur Sel B16-F1

Sugiharto

Ariff²,

Ahmad³

et al. 2012

Berkala Penelitian Hayati

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Melanin inhibitors have become increasingly important ingredients in medication and cosmetics for the prevention of hyperpigmentation. In the last few years, a huge number of natural herbal extracts have been tested as inhibitors of melanin synthesis and some of these effects are related to the antioxidant properties. The objectives of this study were to determine of curcumin properties as antioxidant activity and melanin inhibitors. In this study, our data indicated that antioxidant assay with DPPH showed IC 50 was 16,05 μg/ml. In the absence of α-MSH (α-Melanocyte Stimulating Hormone), melanin content assay in cell B16-F1 indicated that the highest activity of curcumin to reduce melanin content of 45,67% at 25 μg/ml. Meanwhile, in the presence of α-MSH at the same concentration indicated that the highest activity was 53,87%. Based on the data, curcumin has potential properties as antioxidant activity and melanin inhibitor.

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“…Although vicenin-1 possesses unceasingly expanding the list of postulated targets, exploration of its pharmacological properties is still poor due to lack of pharmacokinetic studies. However, it has been well documented that this flavonoid often have poor bioavailability due to their pre-systemic metabolism (Gee et al 2000;Barnes et al 2004). Thus, these promising pharmacological effects prompted researchers to investigate and characterize the pharmacokinetic profiling of vicenin-1 isolated from fenugreek seeds.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies

Kandhare

Bodhankar

Thakurdesai

2016

Pharmaceutical Biology

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Context: Vicenin-1, a flavonol glycoside, has potent platelet aggregation inhibition, antioxidant, radioprotectants and anti-inflammatory activities. Objective: To establish a rapid, simple, precise and sensitive high-performance liquid chromatography (HPLC) method for determination of vicenin-1 in rat plasma, and to investigate the pharmacokinetics, tissue distribution and excretion after a single 60 mg/kg oral dose in rats. Materials and methods: Vicenin-1 was extracted by solid-liquid extraction through Tulsicon V R ADS-400 (0.40-1.2 mm). Chromatographic separation was achieved by HPLC with a C 18 column with a mobile phase composed of water and acetonitrile (75:25 v/v) and a flow rate of 1 mL/min along with UV detection at 210 nm. Results: Good linearity of calibration curve was found between 10.5 and 100.5 lg/mL (R 2 ¼ 0.995) for plasma and tissue, whereas 2.5-500 lg/mL (R 2 ¼ 0.999) for the urine and stool samples. The extraction recoveries were 98.51-99.58% for vicenin-1 in plasma, whereas intra-day and inter-day precision were validated by relative standard deviation (%RSD), that came in the ranges of 1.16-1.79% and 1.28-1.73%, respectively. The pharmacokinetics results showed C max (7.039 lg/mL) and T max (2 h) after oral administration of vicenin-1. Tissue distribution study showed that the highest concentration of vicenin-1 was achieved in the liver followed by the lung. Approximately 24.2% of its administered dose was excreted via urinary excretion route. Conclusion: The first-pass metabolism, poor solubility and presence of reducing sugar moiety in vicenin-1 may decrease its bioavailability. The developed method is sensitive, specific and was successfully applied to the pharmacokinetics, tissue distribution and excretion studies of vicenin-1 in rats.ARTICLE HISTORY

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The Importance of In Vivo Metabolism of Polyphenols and Their Biological Actions

Cited by 5 publications

References 31 publications

The effect of natural polyphenol complex of red grape wine ON L-arginine/NO system

The effect of natural polyphenol complex of red grape wine ON L-arginine/NO system

Efektivitas Kurkumin Sebagai Antioksidan Dan Inhibitor Melanin Pada Kultur Sel B16-F1

Development and validation of HPLC method for vicenin-1 isolated from fenugreek seeds in rat plasma: application to pharmacokinetic, tissue distribution and excretion studies

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