Melanin inhibitors have become increasingly important ingredients in medication and cosmetics for the prevention of hyperpigmentation. In the last few years, a huge number of natural herbal extracts have been tested as inhibitors of melanin synthesis and some of these effects are related to the antioxidant properties. The objectives of this study were to determine of curcumin properties as antioxidant activity and melanin inhibitors. In this study, our data indicated that antioxidant assay with DPPH showed IC 50 was 16,05 μg/ml. In the absence of α-MSH (α-Melanocyte Stimulating Hormone), melanin content assay in cell B16-F1 indicated that the highest activity of curcumin to reduce melanin content of 45,67% at 25 μg/ml. Meanwhile, in the presence of α-MSH at the same concentration indicated that the highest activity was 53,87%. Based on the data, curcumin has potential properties as antioxidant activity and melanin inhibitor.
Background: Tentena City is one of the tourist centers with rapid economic growth located in Poso Regency because Poso Lake is very famous and able to change the economic level of the community. But there are still 20% of people who live very poor and 60% of the lower middle class and the remaining 20% of the middle to upper middle. Through the youth community Pukat Tentena is expected to foster and encourage millennials to develop vegetable and fruit entrepreneurs using more modern cultivation techniques. Objectives: empowering the youth community in Tentena city, Pamona Puselemba Subdistrict, Poso Regency, Central Sulawesi with entrepreneurial tomato fruit products and melons produced by hyrdoponik drip irrigation system. Methods: This community service activity was carried out in Tentena village, Pamona Puselemba Subdistrict, Poso Regency, Central Sulawesi Province with TENTENA PUKAT Youth Community partners starting from May to September 2021. Results: Mitra has successfully cultivated tomato and melon plants with hydroponic drip irrigation system techniques in green houses until they are obtained salesable results. The average number of tomatoes per stalk is 4.05 and the average fruit diameter is 5.1 cm; While the average weight of melons is 1.2 -1.8 kg. Conclusion: The results of this community service activity provide benefits for partners, namely providing additional knowledge about how to cultivate tomatoes and melons with hydroponic drip irrigation system techniques and increase partner income by selling tomatoes and melons from hydroponic cultivation.
Lead induced oxidative stress contributes to increase the productivity of reactive oxygen species (ROS) and to disrupt the antioxidant balance. Gynura procumbens adventitious root (GPAR) methanol extract contains abundant phenolic and flavonoids compounds as antioxidants and can be used as traditional medicinal plants. The objective of this study is to evaluate the protective effect of GPAR against lead acetate toxicity in mice to haematological parameter, histological of hepatic cells, and activities of antioxidant enzymes. The data obtained from five groups of treatment: P1 (control), P2 (Pb acetate-100 mg/L), P3 (GPAR-100 mg/L + Pb acetate-100 mg/L), P4 (GPAR-200 mg/L + Pb acetate-100 mg/L), P5 (GPAR-300 mg/L + Pb acetate-100 mg/L). The results indicated that administration of methanol extract of GPAR can prevent the decreasing of haematological parameter, maintain the percentage of normal hepatic cells, activities of superoxide dismutase (SOD), and catalase (CAT) due to lead acetate treatment. The effective dose of GPAR extract was 300 mg/L. This study provides that methanol extract of G. procumbens adventitious root exerts protective effects against lead acetate toxicity in mice.
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