The Importance of Immobilization of Anti-Inflammatory Drugs to Increase the Effectiveness of Their Use in the Treatment of Mild Chronic Periodontitis

Abstract

Chronic generalized periodontitis of mild severity is characterized, along with inflammation, by minor radiological manifestations of destructive processes in the periodontal tissues. This determines the importance of choosing an algorithm for complex treatment of patients using immobilized anti-inflammatory drugs to achieve stable remission.
 The aim of the study was to study the effect of immobilization on the effectiveness of nonsteroidal anti-inflammatory drugs in the treatment of mild chronic generalized periodontitis.
 Research materials and methods. The study included the results of treatment of 180 patients with mild chronic periodontitis, who were divided into three groups depending on the drug used: in the first — based on benzidamine hydrochloride; in the second — based on etoricoxib, in the third — based on naphthylpropionic acid. In each group, two subgroups were identified "a" and "b": in subgroups 1a, 2a, 3a, a non-steroidal anti-inflammatory drug was used without immobilization. In subgroups 1b, 2b, 3b was immobilized. To assess the effect of immobilization on the effectiveness of the drugs, the results of therapy between subgroups were compared six months after the course of treatment. The periodontal index, PMA, and laser Doppler flowmetry parameters were used to study the clinical results.
 The results of the study. When analyzing the totality of indicators obtained after six months, it was found that in subgroups 1a, 2a, 3a, the effectiveness of treatment was 78.9%. A comparison of the studied index and functional indicators obtained after six months allowed us to state that in subgroups 1b, 2b, 3b, periodontitis was in the stabilization phase, that is, the effectiveness of treatment using immobilized drugs was 93.3%.
 Conclusion. The immobilization of nonsteroidal anti-inflammatory drugs on sorbents increases the effectiveness of their use in the treatment of chronic generalized periodontitis of mild severity from 78.9% to 93.3%.

Effectiveness of Treatment of Chronic Generalized Periodontitis Using Photodynamic and Anti-Inflammatory Therapy

“…Воспалительно-деструктивные заболевания пародонта, к которым относится хронический генерализованный пародонтит (ХГП), благодаря глобальному распространению и недостаточной эффективности лечения остаются нерешенной проблемой медицинского и социального значений. Современные представления о взаимовлиянии пародонтопатогенной микробиоты и факторов местного иммунитета в формировании характера и интенсивности воспалительного ответа с возможным развитием деструктивных процессов в пародонте, позволяют констатировать, что эффективная терапия ХГП должна предусматривать воздействие на оба эти компонента, т е включать антимикробную и хост модулирующую (реакция макроорганизма) составляющие [1][2][3][4][5].…”