Chronic generalized periodontitis of mild severity is characterized, along with inflammation, by minor radiological manifestations of destructive processes in the periodontal tissues. This determines the importance of choosing an algorithm for complex treatment of patients using immobilized anti-inflammatory drugs to achieve stable remission. The aim of the study was to study the effect of immobilization on the effectiveness of nonsteroidal anti-inflammatory drugs in the treatment of mild chronic generalized periodontitis. Research materials and methods. The study included the results of treatment of 180 patients with mild chronic periodontitis, who were divided into three groups depending on the drug used: in the first — based on benzidamine hydrochloride; in the second — based on etoricoxib, in the third — based on naphthylpropionic acid. In each group, two subgroups were identified "a" and "b": in subgroups 1a, 2a, 3a, a non-steroidal anti-inflammatory drug was used without immobilization. In subgroups 1b, 2b, 3b was immobilized. To assess the effect of immobilization on the effectiveness of the drugs, the results of therapy between subgroups were compared six months after the course of treatment. The periodontal index, PMA, and laser Doppler flowmetry parameters were used to study the clinical results. The results of the study. When analyzing the totality of indicators obtained after six months, it was found that in subgroups 1a, 2a, 3a, the effectiveness of treatment was 78.9%. A comparison of the studied index and functional indicators obtained after six months allowed us to state that in subgroups 1b, 2b, 3b, periodontitis was in the stabilization phase, that is, the effectiveness of treatment using immobilized drugs was 93.3%. Conclusion. The immobilization of nonsteroidal anti-inflammatory drugs on sorbents increases the effectiveness of their use in the treatment of chronic generalized periodontitis of mild severity from 78.9% to 93.3%.
Subject. Periodontitis is an inflammatory and destructive process in periodontal tissues, the main etiological factor of which, according to modern concepts, is the microbial invasion of the gingival groove by qualitatively and quantitatively modified microorganisms of cervical plaque. Based on the etiopathogenetic bacterial-vascular mechanisms of the occurrence and progression of inflammatory and destructive periodontal diseases, the use of low-energy (low-intensity) laser exposure was included in all the algorithms for the comprehensive treatment of periodontitis that we studied. Objective: to study the effect of low-intensity laser radiation in combination with local non-steroidal anti-inflammatory drugs on the effectiveness of complex treatment of periodontitis. Methodology. The study involved 120 patients (60 men and 60 women), equally divided into four groups depending on the treatment performed. A randomized controlled trial with discrete longitudinal open observation was conducted. The therapy included the implementation of professional oral hygiene using an ultrasound apparatus, sandblasting, polishing all surfaces of the teeth, a hygiene lesson, recommendations. The methodology of pharmacological treatment was to perform the application of the anti-inflammatory drugs Oralsept and Arkoxia to the periodontal area for 15 minutes with a course of 10 procedures. In the second and fourth groups, low-energy laser exposure was performed using the Optodan apparatus in the second mode for 15 minutes. The course of therapy was 10 procedures. The clinical study was conducted according to generally accepted principles with mandatory x-ray control and an index assessment of the periodontal condition. Results. After a six-month observation period, in the first and third groups, there was a deterioration in both index and hemodynamic digital data, and in the second and fourth indicators remained at a fairly positive level, indicating the effectiveness of the therapy. Conclusions. The use of NLV increases the effectiveness of local exposure to non-steroidal anti-inflammatory drugs "Arkoxia" and "Oralsept" by 16 and 19 % respectively. The positive effect of NLV is maintained throughout the observation period.
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