The importance of determining reference intervals for Laboratory Medicine

Slhessarenko, Natasha; Andriolo, Adagmar

doi:10.5935/1676-2444.20160019

Cited by 9 publications

(11 citation statements)

References 9 publications

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“…The UCB is composed of white blood cells (WBC), red blood cells (RBC), plasma, platelets and is also rich in hematopoietic stem cells, which have immense potential to cure the malignant and genetic disorder. Therefore, establishing of hematological RI among newborns from UCB is very important for neonatologist for the diagnosis RBC disorders (like anemia and polycythemia), hematological malignancy, platelet disorders (like thrombosis and thrombocytopenia), autoimmune disease, certain genetic disorders problems, monitoring of the patients during in a therapeutic regimen and diagnosis of various bacterial infections [ 5 – 7 ]. It is widely known that newborn hematological parameters are different from those of infants or adults.…”

Section: Introductionmentioning

confidence: 99%

Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study

2020

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Background: Hematological reference intervals are used for medical decision tools for interpretation of numerical test results. Establishing of hematological interval among newborn babies is very important for the diagnosis of malignancy, anemia, bleeding disorders, and various infections. There are no locally established hematological reference intervals in Ethiopia. Thus, the aim of this study is to establish locally determined hematological reference interval among full-term newborns. Methods: A cross-sectional study was conducted from May 15 to July 30 2019 among 151 apparently healthy fullterm newborns at Gondar University Hospital. About 3 ml of cord blood was obtained for analysis of Hematological parameters and determined by using Sysmex KX-21N (Sysmex Corporation Kobe, Japan) automated analyzer. Median, 2.5th and 97.5th percentile were computed. Result: Male to female ratio was almost equal. All hematological parameter had no statistically significant difference between males and females. The delivery types were not influenced its hematological values. The reference interval of white blood cells, red blood cells, platelets, hemoglobin, hematocrit, mean cell volume, and mean cell hemoglobin were (7.64-22.16) x10 9 /l, (3.69-5.47)x10 12 /l, (132.74-413.4) x10 9 /l, (13.32-19.64) g/dl and (39.42-58.06)%, (91.6-113.22)fl, and (30.48-38.02 pg), respectively. Conclusions: All hematological reference intervals were established from full-term newborns at University of Gondar hospital was different from other studies in Nigeria, Iraq, Pakistan, Nepal, Saudi Arabia and Iran. Therefore, own determined reference value is very important for the clinicians to correctly diagnosis the patients at health facility levels.

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Section: Introductionmentioning

confidence: 99%

Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study

2020

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“…5 The characteristics of the population in which the reference range is determined and the population to which it is applied must be compatible. 6 Hematological tests are done routinely and are useful in the diagnosis of many diseases as well as in the investigation of the extent of damage to blood. 7 Hematologic RIs have been established long ago for Caucasian population in Europe and North America.…”

Section: Introductionmentioning

confidence: 99%

Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia

et al. 2018

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Background:Clinical laboratory reference intervals are an important tool to identify abnormal laboratory test results. The generating of hematological parameters reference intervals for local population is very crucial to improve quality of health care, which otherwise may lead to unnecessary expenditure or denying care for the needy. There are no well-established reference intervals for hematological parameters in southwest Ethiopia.Objective:To generate hematological parameters reference intervals for apparently healthy individuals in southwest Ethiopia.Methods:A community-based cross-sectional study was conducted involving 883 individuals from March to May 2017. Four milliliter of blood sample was collected and transported to Jimma University Medical Center Laboratory for hematological analysis and screening tests. A hematological parameters were measured by Sysmex XS-500i hematology analyzer (Sysmex Corporation Kobe, Japan). The data were analyzed by SPSS version 20 statistical software. The non-parametric independent Kruskal–Wallis test and Wilcoxon rank-sum test (Mann–Whitney U test) were used to compare the parameters between age groups and genders. The 97.5 percentile and 2.5 percentile were the upper and lower reference limit for the population.Results:The reference interval of red blood cell, white blood cell, and platelet count in children were 4.99 × 1012/L (4.26–5.99 × 1012/L), 7.04 × 109/L (4.00–11.67 × 109/L), and 324.00 × 109/L (188.00–463.50 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in adults was 5.19 × 1012/L (4.08–6.33 × 1012/L), 6.35 × 109/L (3.28–11.22 × 109/L), and 282.00 × 109/L (172.50–415.25 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in geriatrics were 5.02 × 1012/L (4.21–5.87 × 1012/L), 6.21 × 109/L (3.33–10.03 × 109/L), and 265.50 × 109/L (165.53–418.80 × 109/L), respectively. Most of the hematological parameters showed significant differences across all age groups.Conclusion:Most of the hematological parameters in this study showed differences from similar studies done in the country. This study provided population-specific hematological reference interval for southwest Ethiopians. Reference intervals should also be established in the other regions of the country.

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“…Furthermore, specific RIs may be required for each region due to differences in genetic and environmental, ethnic and cultural factors 17,18 . Furthermore, while there have been several studies that have reported the pediatric RIs for different biomarkers, the recommended RIs for older people in different regions are scarce 19 . Routine laboratory tests include fasting blood glucose (FBG) and lipid profile that are used to manage cardiometabolic disorders, such as diabetes mellitus and cardiovascular diseases (CVDs) 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran

et al. 2020

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Age-and sex-specific reference intervals (RIs) for some biochemical tests may be useful for their interpretation, due to the variations in lifestyle and genetic, or ethnic factors. The aim of this study was to obtain RIs for some routine biochemical markers including a serum lipid profile, fasting blood glucose (FBG), aspartate and alanine aminotransferase (AST and ALT), uric acid, and body mass index (BMI) in subjects who attended primary healthcare centers. The large database of primary healthcare centers uses RIs to report results for children, adolescents, and young and old adults. RIs were obtained by using the indirect method, recommended by the CLSI Ep28-A3 guidelines. RIs for FBG, BMI, and serum lipid profile, including triglyceride, total cholesterol, highdensity lipoprotein cholesterol, and low-density lipoprotein cholesterol in people aged 18 to 120 years, were obtained without age/sex segmentation. RIs for serum AST, ALT, and uric acid were obtained without age segmentation,

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The importance of determining reference intervals for Laboratory Medicine

Cited by 9 publications

References 9 publications

Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study

Hematological reference intervals among full-term newborns in Ethiopia: a cross-sectional study

Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia

Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran

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