The importance of assessing the rate of bone turnover and the balance between bone formation and bone resorption during daily teriparatide administration for osteoporosis: a pilot study

Nakatoh, Shinichi

doi:10.1007/s00774-015-0665-3

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…Bone resorption markers are useful for evaluating bone resorption inhibitors, such as BPs and SERMs, whereas bone formation markers are useful for evaluating bone formation promoters such as teriparatide [11] . However, it is insufficient to evaluate either the bone formation marker or bone resorption marker, when there is any dissociation between observed trends in both markers, such as that occurring in this study [12] . When the effect of denosumab was evaluated only in BAP at week 4, the balance might be underestimated, and when it was evaluated only in TRACP-5b, the turnover rate might be overestimated.…”

Section: Discussionmentioning

confidence: 85%

Bone turnover rate and bone formation/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change

Nakatoh

2017

Osteoporosis and Sarcopenia

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ObjectivesThis study aimed to investigate the correlation between bone mineral density (BMD) and the turnover rate [√(MoMf2 + MoMr2), multiple of median formation (MoMf) was calculated as bone-specific alkaline phosphatase (BAP) value/18.6 and multiple of median resorption (MoMr) as tartrate-resistant acid phosphatase 5b (TRACP-5b) value/463] and the balance (MoMf/MoMr) and to compare differences in therapeutic effects evoked by differences in previous treatments.MethodsIn 51 osteoporotic women treated with bisphosphonates (BPs) or selective estrogen receptor modulators (SERMs), BMD was measured at 0, 24, and 48 weeks after denosumab administration. The values of BAP and TRACP-5b were measured at 0, 4, 12, 24, 36, and 48 weeks.ResultsThe turnover rate decreased at week 4 and decreased further at week 12. The balance indicated a relative predominantly formative state at week 4. This balance became higher in the SERM group than in the BP group at week 4. A correlation was observed between the rate of BMD change and turnover rate at weeks 0 and 4.ConclusionsIt is necessary to evaluate the turnover rate and balance to determine the therapeutic effect of denosumab, which induces dissociation between the trends in the bone turnover markers. Turnover rate and balance during the early stages of denosumab treatment may be predictive factors of BMD. When switching from bone resorption inhibitors to denosumab, it was necessary to consider the beginning values that were affected by the previous treatment. The state of relative anabolism is greater at 4 weeks when the previous treatment involved SERMs rather than BPs.

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Section: Discussionmentioning

confidence: 85%

Bone turnover rate and bone formation/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change

Nakatoh

2017

Osteoporosis and Sarcopenia

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“…Both the bone formation and bone resorption levels might be enhanced in the elderly postmenopausal women in our study, as suggested by the fact that the bone resorption biomarker, β-CTX, was positively correlated with the ALP, OST and P1NP levels in the current study. It has been widely accepted that the net bone gain or loss of the skeleton is determined by the balance of the formation and resorption of the bone (Shieh et al, 2016, Nakatoh, 2016). However, the biomarkers of resorption and formation alone have poor predictive ability for the BMD, since both the bone resorption and formation were increased in subjects with increased bone turnover, regardless of whether there is a net gain or loss of bone.…”

Section: Discussionmentioning

confidence: 99%

Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

Chen

Duan

et al. 2017

EBioMedicine

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Total 25(OH)D levels were determined to assess bone health in elderly populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations. Whether bioavailable 25(OH)D level is a superior biomarker for vitamin D than total 25(OH)D level regarding the BMD and the bone metabolism were not yet fully understood. With a community based cross-sectional study of 967 postmenopausal women, we found that the variant rs7041, but not rs4588, of DBP was significantly associated with the blood DBP level, which was positively correlated with the total 25(OH)D level but negatively associated with bioavailable 25(OH)D levels. Both total and bioavailable 25(OH)D levels were significantly correlated with the BMD value in postmenopausal women; however, only the bioavailable 25(OH)D level was an independent determinant of the BMD values when adjusted for age, body mass index and bone turnover biomarkers (OST and β-CTX). The bioavailable and total 25(OH)D were negatively correlated with bone formation biomarkers (OST, PINP and ALP) and PTH levels, while they were positively correlated with osteoprotegerin (OPG) level; however, the bone resorption biomarker (β-CTX) was not correlated with the 25(OH)D levels. An increment of PTH level, along with reduced bioavailable 25(OH)D levels, was evident when the bioavailable 25(OH)D level was < 5 ng/mL, which may be the optimal cutpoint for sufficient vitamin D in Chinese elderly women. The blood calcium, magnesium, ALP, TSH, FGF23, and phosphorus levels were not correlated with the total or the bioavailable 25(OH)D levels. These results suggested that high bioavailable 25(OH)D levels were correlated with reduced bone turnover processes and were a biomarker superior to total 25(OH)D for vitamin D in assessing the risks of bone-related diseases. The results indicate that the bioavailable 25(OH)D level should be determined in assessing the bone health.

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“…This standardization method represents the balance of bone formation and resorption, together with the rate of bone turnover, although it does not necessarily reflect the bone remodeling unit and is not a direct assessment at the tissue level. The utility of this standardization method to indicate the overall balance between bone resorption and formation has been previously shown in adults [33][34][35][36], although there is no evidence about their use in children and adolescents.…”

Section: Blood Analysismentioning

confidence: 99%

Effects of post exercise protein supplementation on markers of bone turnover in adolescent swimmers

Theocharidis

McKinlay

Vlachopoulos

et al. 2020

Journal of the International Society of Sports Nutrition

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Background: This study examined the effects of whey protein supplementation, compared with an isocaloric carbohydrate beverage and water, consumed immediately following an intense swimming trial on bone turnover in adolescent swimmers. Methods: Fifty-eight (31 female, 27 male) swimmers (14.1 ± 0.4 years) were stratified into three groups matched for age, sex and body mass. The protein and carbohydrate groups consumed two isocaloric post-exercise beverages each containing 0.3 g . kg − 1 of whey protein (with~6 mg of calcium) or maltodextrin while the control group consumed water. Participants provided a morning, fasted, resting blood sample, then performed an intense swimming trial consisting of a maximal 200 m swim followed by a high intensity interval swimming protocol (5x100m, 5x50m and 5x25m; 1:1 work-to-rest ratio). Following swimming, they consumed their first respective postexercise beverage, and 2 h later, they performed a second maximal swim immediately followed by the second beverage. Approximately 3 h after the second beverage, two post-consumption blood samples were collected at 8 h and 24 h from baseline. Procollagen type 1 intact N-terminal propeptide (PINP) and carboxy-terminal collagen crosslinks (CTXI) were measured in serum. The multiples of medians of PINP and CTXI were also used to calculate bone turnover rate and balance. Results: No significant changes were observed in PINP. CTXI increased (+ 11%) at 8 h in all groups, but then significantly decreased (− 22%) at 24 h in the protein group only. The protein group also had a significantly higher calculated rate of bone turnover at 8 h and 24 h compared to baseline, which was not observed in the other groups.Conclusions: These results shed light on the potential importance of protein consumed shortly after intense swimming in promoting positive bone turnover responses up to 24 h following exercise in adolescent athletes. Clinical trial registration: ClinicalTrials.gov PRS; NCT04114045. Registered 1 October 2019 -Retrospectively registered.

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The importance of assessing the rate of bone turnover and the balance between bone formation and bone resorption during daily teriparatide administration for osteoporosis: a pilot study

Cited by 10 publications

References 32 publications

Bone turnover rate and bone formation/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change

Bone turnover rate and bone formation/resorption balance during the early stage after switching from a bone resorption inhibitor to denosumab are predictive factors of bone mineral density change

Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

Effects of post exercise protein supplementation on markers of bone turnover in adolescent swimmers

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