Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

Li, Chenguang; Chen, Peizhan; Duan, Xiaonan; Wang, Jing; Shu, Bing; Li, Xiaoguang; Ba, Qian; Li, Jingquan; Wang, Yongjun; Wang, Hui

doi:10.1016/j.ebiom.2016.11.029

Cited by 25 publications

(26 citation statements)

References 46 publications

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“…The conflicting findings can partially be elucidated by ethnic differences in the populations and wider age groups (20–80 years). Additionally, role of bioavailable 25(OH)D but not total 25(OH)D as an independent determinant for BMD is also under debate [ 61 , 62 ] and may be a reason for no association.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Kaushal

Vohora

Jalali

et al. 2018

Osteoporosis and Sarcopenia

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ObjectivesAn understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis of osteoporosis and management of its complications in later life. This study aimed to screen the bone health status and factors associated with osteoporosis in an apparently healthy Indian population.MethodsA retrospective review of medical records was done in a tertiary-care hospital for the subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, and lumbar-spine.ResultsWe evaluated 524 subjects (age, 50.0 ± 12.4 years) including 41.2% female and 58.8% male subjects. Osteoporosis was present in 6.9% subjects (female, 11.1%; male, 4.2%) and osteopenia in 34% subjects (female, 40.3%; male, 29.9%). Absolute BMD was higher in male subjects (P < 0.001) compared to female subjects at all bone sites. Prevalence of osteoporosis increased with age in female subjects, but not in male subjects. Osteoporosis rates in the age-groups of 30–39, 40–49, 50–59, 60–69, and ≥70 years were 3%, 3.4%, 14.3%, 18.6%, and 36.4%, respectively in female subjects while prevalence in male subjects was 0%, 4%, 6.5%, 4.3%, and 5.6%, respectively, at lumbar spine. Height (r = 0.234–0.358), weight (r = 0.305–0.388), body mass index (r = 0.143–0.285) and physical activity (r = 0.136–0.153) were positively; and alkaline phosphatase (r = −0.133 to −0.203) was negatively correlated with BMD (all P < 0.01) at all sites. These parameters retained significant correlation after controlling for age and sex. No correlation of serum 25-hydroxy-vitamin-D and calcium was noted with BMD (P > 0.05) at any site.ConclusionsFurther data on absolute BMD, T scores, and prevalence rates of osteoporosis/osteopenia on multiple bone sites have been presented in this article.

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Section: Discussionmentioning

confidence: 99%

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Kaushal

Vohora

Jalali

et al. 2018

Osteoporosis and Sarcopenia

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“…DBP is one of several regulators of serum vitamin D levels, with around 85–90% of the circulating vitamin D pool being bound to DBP [6, 7]. Total vitamin D correlates positively with DBP concentrations [8, 9].…”

Section: Introductionmentioning

confidence: 99%

“…These isoforms have different binding affinity for vitamin D [7] as well as different glycosylation patterns [10]. rs4588 and rs7041 have been associated with DBP concentrations [8, 11–14] and vitamin D levels [12, 15–18] in various populations. Another GC gene variant is the rs2282679 polymorphism, located at the 3’ untranslated region (3′ UTR) of the GC gene, which is involved in the modulation of gene expression and reportedly associated with vitamin D levels [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms

et al. 2019

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Vitamin D deficiency is highly prevalent worldwide, and vitamin D-binding protein (DBP) a major regulator of serum vitamin D levels. The rs4588 and rs7041 polymorphisms of the GC gene constitute the genetic basis of the three major isoforms of circulating DBP (GC1s, GC1f, and GC2), while the rs2282679 variant is located in an important regulatory region of the GC gene. The aim of this study was to assess the prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency and to ascertain whether it is associated with DBP levels and with GC gene variants. Biorepository samples of 443 women aged 20 to 72 years, with no evidence of clinical disease, were analyzed. Circulating levels of 25(OH)D were considered sufficient if ≥20 ng/mL and deficient if <20 ng/mL. Genotype analysis was performed by RT-PCR. Mean age was 53.4±9.4 years; mean BMI was 27.8±5.8 kg/m2. The overall sample had mean 25(OH)D levels of 22.8±8.3 ng/mL; 39.7% of participants had deficient circulating 25(OH)D levels. Higher prevalence ratios (PR) of 25(OH)D deficiency were found for the CC genotype of rs2282679 (PR 1.74; 95%CI 1.30 to 2.24; p<0.001), GC2 isoform (PR 1.66; 95%CI 1.17 to 2.38; p = 0.005), time since menopause (PR 1.02; 95%CI 1.003 to 1.03, p = 0.016), and HOMA-IR (PR 1.02; 95%CI 1.01 to 1.03, p = 0.004). DBP levels (per 30 μg/mL increase in DBP) were associated with lower PR for 25(OH)D deficiency (PR 0.89; 95%CI 0.80;0.99; p = 0.027). Except for HOMA-IR, these prevalence ratios remained significant after adjustment for age and BMI. In conclusion, the rs2282679 polymorphism and the GC2 isoform of DBP were associated with lower serum DBP levels and with susceptibility to 25(OH)D deficiency in Brazilian women with no evidence of clinical disease.

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“…[18][19][20] A study from China suggested that bioavailable 25(OH)D was a superior biomarker than total 25(OH)D regarding the bone metabolism, and that vitamin D intervention may improve the bone health in elderly populations. 21 This study suggests that we should try to seek the relevance of bioavailable 25(OH)D rather than total 25(OH)D to find its correlation with different parameters.…”

Section: Serum Vitamin D Level In Postmenopausal Womenmentioning

confidence: 99%

Prevalence of vitamin D deficiency in postmenopausal women and its association with fasting blood sugar

Sinha

Goel

Sah

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Studies have reported high prevalence of vitamin D deficiency in this group of women and a few has reported its association with diabetes and metabolic syndrome. 1 Worldwide the prevalence of vitamin D deficiency is 70-100% in general population among all socio-economic status. 2 In India, the community-based studies done on apparently healthy controls reported a prevalence ranging from 50% to 94% with 53.4% in postmenopausal women ABSTRACT Background: Vitamin D is indispensable for human body as it caters for both skeletal as well as extra-skeletal needs, especially in postmenopausal women. Aim of this study was to know the prevalence of vitamin D deficiency among apparent healthy postmenopausal women and to find its association with fasting blood sugar. Methods: This was a cross-sectional observational study of postmenopausal women attending Gynae OPD of Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, over a period of six months. Apparently healthy postmenopausal women were selected after satisfying inclusion-exclusion criteria and were subjected to fasting blood sugar and serum 25-hydroxy-vitamin D level. They were categorized as vitamin D deficient, insufficient or sufficient according to corresponding levels of <20ng/ml, 20-30ng/ml or >30ng/ml respectively. Upper reference level for fasting blood sugar was taken as 110mg/dl. Statistical analysis was done to see the association between vitamin D deficiency and fasting blood sugar. Results: Mean age of study group was 56.9 years and the average age of attainment of menopause was 50.3 years. Prevalence of vitamin D deficiency (57.4%) including insufficiency (13%) among postmenopausal women was high 70.4%, but there was no association between hypovitaminosis D and fasting blood sugar (p=0.949). Conclusions: Despite high prevalence of vitamin D deficiency among Indian postmenopausal women, there is no correlation between it and fasting blood sugar.

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Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women

Cited by 25 publications

References 46 publications

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms

Prevalence of vitamin D deficiency in postmenopausal women and its association with fasting blood sugar

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