The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review

Canbolat, Eren; Çakiroğlu, Funda Pınar

doi:10.1080/10408398.2022.2087595

Cited by 9 publications

(1 citation statement)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased lipogenesis and decreased lipolysis are the two main causes of hepatic lipid accumulation and elevated serum lipid levels . Studies have proven that modulation of hepatic lipogenesis and lipolysis is considered a feasible approach to alleviating obesity-induced lipid metabolism disorder. − Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an essential energy regulator that maintains cellular energy balance by modulating the glucose and lipid metabolism . Relevant research has revealed that phosphorylated AMPK modulates the expression of a series of downstream proteins, including acetyl-CoA carboxylase (ACC), carnitine palmitoyltransferase-1 (CPT-1), and fatty acid synthase (FAS), to suppress lipid synthesis and promotes free fatty acid (FFA) β-oxidation .…”

Section: Introductionmentioning

confidence: 99%

Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice

Wei

Peng

Xiao

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

The major characteristics of obesity are abnormal lipid metabolism, chronic inflammation, and imbalanced gut microbiota. It has been reported that lactic acid bacteria (LAB) possess potential for alleviating obesity, considering which the strainspecific functions and diverse mechanisms and the roles and mechanisms of various LAB are worthy of investigation. This study aimed to validate and investigate the alleviating effects and underlying mechanisms of three LAB strains, Lactiplantibacillus plantarum NCUH001046 (LP), Limosilactobacillus reuteri NCUH064003, and Limosilactobacillus fermentum NCUH003068 (LF), in high-fatdiet-induced obese mice. The findings demonstrated that the three strains, particularly LP, suppressed body weight gain and fat deposition; ameliorated lipid disorders, liver and adipocyte morphology, and chronic low-grade inflammation; and reduced lipid synthesis via activating the adenosine 5′-monophosphate-activated protein kinase (AMPK) signaling pathway. In addition, LP and LF decreased the enrichment of bacteria positively correlated with obesity, like Mucispirillum, Olsenella, and Streptococcus, but facilitated the growth of beneficial bacteria negatively correlated with obesity, like Roseburia, Coprococcus, and Bacteroides, along with increasing the short-chain fatty acid levels. It is deduced that the underlying alleviating mechanism of LP was to modulate the hepatic AMPK signaling pathway and gut microbiota by the microbiome−fat−liver axis to alleviate obesity development. In conclusion, as a diet supplement, LP has promising potential in obesity prevention and treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice

Wei

Peng

Xiao

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high‐fat diet‐induced mice to alleviate obesity

Tian,

Pan,

Zhou

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

BackgroundYellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O. Ktze, which has yellow leaves and the unique qualities of ‘three green through three yellow’. This study aimed to investigate the anti‐obesity effect of YLGT in mice fed a high‐fat diet (HFD) and to explore the potential mechanisms by regulating the AMPK/ACC/SREBP1c signaling pathways and gut microbiota.ResultsThe results showed that YLGT aqueous extract reduced body weight, hepatic inflammation, fat accumulation and hyperlipidemia in HFD‐induced C57BL/6J mice, and accelerated energy metabolism, reduced fat synthesis, and suppressed obesity by activating the AMPK/CPT‐1α signaling pathway and inhibiting the FAS/ACC/SREBP‐1c signaling pathway. Fecal microbiota transplantation experiment further confirmed that the alteration of gut microbiota, e.g., increasing unclassified_Muribaculaceae and decreasing Colidextribacter, might be an important cause of YLGT water extract inhibiting obesity.ConclusionIn conclusion, YLGT has a broad application prospect in the treatment of obesity and the development of anti‐obesity function beverages.This article is protected by copyright. All rights reserved.

show abstract

The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies

Wei

Wang

Liu

2023

Environmental Pollution

View full text Add to dashboard Cite

The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review

Cited by 9 publications

References 72 publications

Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice

Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice

Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high‐fat diet‐induced mice to alleviate obesity

The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies

Contact Info

Product

Resources

About