The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies

Wei, Yile; Wang, Linping; Liu, Jing

doi:10.1016/j.envpol.2023.121927

Cited by 10 publications

(5 citation statements)

References 233 publications

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“…Besides genetics, environmental factors such as viral infections and pesticide exposure have been implicated with the development of T1D (18)(19)(20)(21)(22) (Supplementary Table 1). However, the causal relationship between viral infections and T1D remains complex and multifaceted.…”

Section: Discussionmentioning

confidence: 99%

“…Besides genetic etiology, environmental factors such as viral infections, pesticide exposure, lifestyle and dietary factors as well as vitamin D deficiency have all been individually associated with the development of T1D (17)(18)(19) (Supplementary Table 1).…”

Section: Environmental Factors In the Pathophysiology Of T1dmentioning

confidence: 99%

“…While genetic susceptibility has long been recognized as a key factor in T1D development, it is increasingly evident that environmental influences can play a pivotal role in shaping disease risk (17). Environmental factors such as viral infections and pesticide exposure have been shown to increase susceptibility to T1D (18)(19)(20)(21)(22). Although genetics and environmental factors individually have been associated with T1D, limited information is available regarding their cumulative contribution in the disease process.…”

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confidence: 99%

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Gene-environment interaction in the pathophysiology of type 1 diabetes

Mittal,

Camick,

Lemos

et al. 2024

Front. Endocrinol.

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Type 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities. However, the precise trigger of autoimmunity and disease onset remain incompletely elucidated. This integrative perspective article synthesizes the cumulative role of gene-environment interaction in the pathophysiology of T1D. Genetics plays a significant role in T1D susceptibility, particularly at the major histocompatibility complex (MHC) locus and cathepsin H (CTSH) locus. In addition to genetics, environmental factors such as viral infections, pesticide exposure, and changes in the gut microbiome have been associated with the development of T1D. Alterations in the gut microbiome impact mucosal integrity and immune tolerance, increasing gut permeability through molecular mimicry and modulation of the gut immune system, thereby increasing the risk of T1D potentially through the induction of autoimmunity. HLA class II haplotypes with known effects on T1D incidence may directly correlate to changes in the gut microbiome, but precisely how the genes influence changes in the gut microbiome, and how these changes provoke T1D, requires further investigations. These gene-environment interactions are hypothesized to increase susceptibility to T1D through epigenetic changes such as DNA methylation and histone modification, which in turn modify gene expression. There is a need to determine the efficacy of new interventions that target these epigenetic modifications such as “epidrugs”, which will provide novel avenues for the effective management of T1D leading to improved quality of life of affected individuals and their families/caregivers.

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Section: Discussionmentioning

confidence: 99%

Section: Environmental Factors In the Pathophysiology Of T1dmentioning

confidence: 99%

mentioning

confidence: 99%

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Gene-environment interaction in the pathophysiology of type 1 diabetes

Mittal,

Camick,

Lemos

et al. 2024

Front. Endocrinol.

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“…Statistically, this disease category was found to be not over-nor under-represented in the AOP-Wiki (r = 0.03; p = 0.976; Figure 5). However, as discussed in section 3.4, the focus of AOP developers on diseases such as obesity and diabetes has been relatively limited in general, while the scientific evidence supporting the diabetogenic and obesogenic potential of, for example, pesticides has significantly grown in recent years (Heindel and Blumberg, 2019;Wei et al, 2023). In the broader perspective of diseases related to an organism's energy metabolism, addressing this gap in AOP development is relevant for both human and environmental health: in humans, adverse health effects largely depend on the dietary context (e.g., a highcaloric, high-fat and high-sugar western diet) while in wildlife, where caloric intake is typically limited, any disruption of energy metabolism may have important consequences for supporting survival, growth and reproduction.…”

Section: Case Study 2: Representation Of Aops Leading To Endocrine An...mentioning

confidence: 99%

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Jaylet,

Coustillet,

Smith

et al. 2024

Front. Toxicol.

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Introduction: The Adverse Outcome Pathway (AOP) concept facilitates rapid hazard assessment for human health risks. AOPs are constantly evolving, their number is growing, and they are referenced in the AOP-Wiki database, which is supported by the OECD. Here, we present a study that aims at identifying well-defined biological areas, as well as gaps within the AOP-Wiki for future research needs. It does not intend to provide a systematic and comprehensive summary of the available literature on AOPs but summarizes and maps biological knowledge and diseases represented by the already developed AOPs (with OECD endorsed status or under validation).Methods: Knowledge from the AOP-Wiki database were extracted and prepared for analysis using a multi-step procedure. An automatic mapping of the existing information on AOPs (i.e., genes/proteins and diseases) was performed using bioinformatics tools (i.e., overrepresentation analysis using Gene Ontology and DisGeNET), allowing both the classification of AOPs and the development of AOP networks (AOPN).Results: AOPs related to diseases of the genitourinary system, neoplasms and developmental anomalies are the most frequently investigated on the AOP-Wiki. An evaluation of the three priority cases (i.e., immunotoxicity and non-genotoxic carcinogenesis, endocrine and metabolic disruption, and developmental and adult neurotoxicity) of the EU-funded PARC project (Partnership for the Risk Assessment of Chemicals) are presented. These were used to highlight under- and over-represented adverse outcomes and to identify and prioritize gaps for further research.Discussion: These results contribute to a more comprehensive understanding of the adverse effects associated with the molecular events in AOPs, and aid in refining risk assessment for stressors and mitigation strategies. Moreover, the FAIRness (i.e., data which meets principles of findability, accessibility, interoperability, and reusability (FAIR)) of the AOPs appears to be an important consideration for further development.

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“…As organic pollutants, the residues of pesticides and antibiotics in the environment have always attracted tremendous attention in pollution monitoring [7]. The use of pesticides is beneficial for crops during agricultural production [8]. However, the leaching of excess pesticides from agricultural land to surface water bodies may damage the aquatic ecosystem balance [9].…”

Section: Introductionmentioning

confidence: 99%

Design and Construction of a Mixed-Ligand Coordinated Fluorescent Complex and Its Application for Sensing Ions, Antibiotics, and Pesticides in Aqueous Solution

Zhu,

Jia,

Ding

et al. 2024

Inorganics

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In this work, a fluorescent complex [Zn(NTD)2(DTP)2(H2O)2]·(H2O)0.8 (Complex Zn), (H2NTD = 1,4-naphthalenedicarboxylic acid and DTP = 3,5-di(1,2,4-triazol-1-yl)pyridine) was synthesized. The fluorescent complex was characterized by single-crystal X-ray diffraction, powder X-ray diffraction, and thermogravimetric, elemental, infrared spectroscopy, and fluorescence analyses. In the fluorescence sensing tests, Complex Zn exhibited excellent fluorescence quenching efficiency towards Fe3+, MnO4−, Cr2O72−, nitrofurantoin, and imidacloprid in aqueous media. A mechanism investigation suggested that the fluorescence quenching caused by the quenchers toward the sensor was due to the inner filter effect and the fluorescence resonance energy transfer effect in the fluorescent sensing process.

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The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies

Cited by 10 publications

References 233 publications

Gene-environment interaction in the pathophysiology of type 1 diabetes

Gene-environment interaction in the pathophysiology of type 1 diabetes

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Design and Construction of a Mixed-Ligand Coordinated Fluorescent Complex and Its Application for Sensing Ions, Antibiotics, and Pesticides in Aqueous Solution

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