2013
DOI: 10.1007/s00702-013-0993-1
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The impairment of lysyl oxidase in keratoconus and in keratoconus-associated disorders

Abstract: Keratoconus (KC) is an eye disease characterized by the progressive thinning and protrusion of the cornea, which results in the loss of visual acuity. This disorder remains poorly understood, although recent studies indicate the involvement of genetic and environmental factors. Recently, we have found that the distribution of the cross-linking enzyme lysyl oxidase (LOX) is markedly decreased in about 63 % of keratoconic specimens. Similarly, LOX activity is significantly reduced by 38 % compared to control tis… Show more

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Cited by 34 publications
(24 citation statements)
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“…Dudakova and Jirsova hypothesized that very similar changes in the extracellular matrix, particularly at the level of collagen metabolism, including lysyl oxidase (LOX) impairment in mitral leaflets, may reflect an association between KC and mitral valve prolapse. As such, these findings may also indicate a very similar origin of KC and MVP [33]. …”
Section: Discussionmentioning
confidence: 94%
“…Dudakova and Jirsova hypothesized that very similar changes in the extracellular matrix, particularly at the level of collagen metabolism, including lysyl oxidase (LOX) impairment in mitral leaflets, may reflect an association between KC and mitral valve prolapse. As such, these findings may also indicate a very similar origin of KC and MVP [33]. …”
Section: Discussionmentioning
confidence: 94%
“…137,138 In 63% of cases of keratoconus, LOX distribution has been found to be markedly decreased and its activity to be more than 2.5 times lower than that of control cases. 139,140 A study in Russia has shown that the increase in pH of the tears causes biochemical changes in the periphery of the cornea that prevent the passage of Keratoconus IL-1α, interleukin 1α; KC, keratoconous; β-NGF, nerve growth factor-β; PDGF, platelet-derived growth factor; PGE2, prostaglandin E2; PIGR, polymeric immunoglobulin receptor; RGP, rigid gas permeable; TGF-β1, transforming growth factor β1;…”
Section: Enzymatic Imbalancementioning
confidence: 99%
“…[21] Reduced LOX activity has been detected in the cornea of patients with KC, suggesting a significant role of this gene in the pathogenesis of disease. [15,22,23] Two of the main missense mutations, Arg158Gln (rs1800449) and Pro159Gln (rs41407546), have been described in both Italian and Iranian populations [16,20] . A role of the Arg158Gln mutation in KC has been demonstrated in a genome-wide association study that also identified an SNP associated with the 5'UTR region.…”
Section: Introductionmentioning
confidence: 99%