2015
DOI: 10.1038/eye.2015.63
|View full text |Cite
|
Sign up to set email alerts
|

Keratoconus: an inflammatory disorder?

Abstract: Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with the disease. Recent studies have shown a significant role of proteolytic enzymes, cytokines, and free radicals; therefore, although keratoconus does not meet all the classic criteria for an inflammatory disease, the lack of inflammat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
198
1
28

Year Published

2016
2016
2021
2021

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 275 publications
(230 citation statements)
references
References 150 publications
(231 reference statements)
3
198
1
28
Order By: Relevance
“…Still, there are several reports supporting the notion of a role of inflammation in the thinning and weakening of the corneal tissue in KTCN. 34,35 In 2013, we identified several variants in genes encoded inflammatory molecules, IL1A and IL1B, in a KTCN family, but we observed a random distribution of them between KTCN and normal individuals. On the other hand, in all KTCN patients, we found a c.214+242C4T variant in the IL1RN gene, whose protein product modulates the effect of IL-1.…”
Section: Discussionmentioning
confidence: 85%
“…Still, there are several reports supporting the notion of a role of inflammation in the thinning and weakening of the corneal tissue in KTCN. 34,35 In 2013, we identified several variants in genes encoded inflammatory molecules, IL1A and IL1B, in a KTCN family, but we observed a random distribution of them between KTCN and normal individuals. On the other hand, in all KTCN patients, we found a c.214+242C4T variant in the IL1RN gene, whose protein product modulates the effect of IL-1.…”
Section: Discussionmentioning
confidence: 85%
“…3 Recently, it was suggested that KTCN could be a quasiinflammatory condition. 4 However, the exact causes of this disease are not well characterized, and its complexity and heterogeneity make it difficult to discover the factors that unambiguously trigger the KTCN phenotype.…”
Section: Introductionmentioning
confidence: 99%
“…It is a stromal dystrophy, classified as a progressive, noninflamatory state characterized by lesions leading to decrease in thickness of central and pericentral cornea and consequent hallmark "cone-shaped" form [2]. KC is characterized by a distortion of the biochemical composition of certain corneal layers: a deficit of collagen type VII, XII and VI in the epithelium and of type I, III, V, VI and XII in the stroma.…”
Section: Introductionmentioning
confidence: 99%