The impacts of organochlorines and other persistent pollutants on thyroid and metabolic health

Langer, P

doi:10.1016/j.yfrne.2010.08.001

Cited by 65 publications

(41 citation statements)

References 247 publications

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“…The immune system is particularly vulnerable to POP toxicity, with observations of thymus atrophy and reduced T-lymphocyte functions. POP are associated with changes in lymphocyte proliferation that could result in increased susceptibility to infections (Ritter et al, 1995;Jones and de Voogt, 1999;Ross and Birnbaum, 2001;Levin et al, 2005;Langer, 2010). The children living in these two East Slovakian regions are also exposed to other non-PCB pollutants that could be contributing to the observed effects.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Horváthová¹,

Jahnová²,

Palkovičová³

et al. 2011

Journal of Immunotoxicology

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Section: Discussionmentioning

confidence: 99%

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Horváthová¹,

Jahnová²,

Palkovičová³

et al. 2011

Journal of Immunotoxicology

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“…Independently of the production method, the transfer of POPs into hen eggs, especially into yolk as their bound to egg fat content, has been widely documented for OCPs and other compounds as polychlorobiphenyls (Fournier et al, 2012). For this reason, securing the quality of hen eggs is an important issue for Chronic exposure to POPs was found to interfere with the activity of endogenous hormones in humans, including T4, T3 and TSH (Langer, 2010). Some evidence suggests that OCPs might contribute to increase the risk of exocrine pancreatic cancer (Soliman et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Pesticide Residues in Edible and Unhatched Chicken Eggs in Sharkia Province, Egypt

Abdelfatah¹,

Abu-Zeid²

2015

Adv. Anim. Vet. Sci.

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| This work is proposed to investigate pesticide residues in chicken eggs in El-Sharkia Province, Egypt. Analysis of pesticide residues was performed on 120 egg samples included 80 random edible egg samples (40 farm and 40 home produced hen eggs) and other 40 unhatched eggs. Edible eggs were collected from different stores, places and supermarkets. unhatched incubated eggs were collected from different hatcheries during the winter season. Organochlorine pesticides (OCPs) and organophophorous insecticides (OPIs) residue analysis of samples was done using Agilent Gas chromatograph (GC) Model 6890 N. The results revealed presence of OPIs in higher concentration in home produced eggs than that in farm produced eggs, while OCPs present in farm produced egg in higher levels than that in home produced one. Unlike other studies we have not found higher levels of exposure for most pesticides in those consumers choose home produced eggs, and even farm produced eggs. Regarding unhatched eggs dimethioate recorded the highest concentration which exceeded Maximum Residual Limits (MRLs) of (0.05) mg/kg in all the examined samples. None of the other detected pesticide residues exceeded (MRLs). It was concluded that the levels of pesticide residues in edible eggs either home or farm produced eggs should not exceed Accepted Daily Intake (ADI) established by the World Health Organization (WHO) Joint Meeting on Pesticide Residues Report ( JMPR). The study suggests the need for further investigations to determine toxic mechanisms by which dimethoate distress chick emberyos at different developmental stages and result in hatching failure.

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“…Однако выводы о влиянии ДДТ на продукцию тиреоидных гормонов во многом противоречивы. У лиц, подвергавшихся воздействию различных доз ДДТ, отмечалось как снижение продукции Т 4 и повышение продукции Т 3 , так и отсутствие каких-либо изменений тиреоидного статуса [10][11][12][13].…”

Section: результаты и обсуждениеunclassified

Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT

Yaglova

Yaglov

2014

BIOMED KHIM

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Endocrine disruptors are exogenous substances that exhibit hormone-like action and consequently disrupt homeostatic action of endogenous hormones. DDT is the most common disruptor. The objective was to evaluate changes in thyroid hormone secretion after long-term exposure to low doses of DDT. The experiment was performed on male Wistar rats. The rats were given DDT at doses of 1.89±0.86 мg/kg/day and 7.77±0.17 мg/kg/day for 6 and 10 weeks. Dose dependent increase of serum total thyroxine, total triiodthyronine, and thyroid peroxidase was revealed after 6 weeks exposure. After 10 weeks free thyroxine secretion was reduced. Such alterations of the thyroid status are typical for iodine deficient goiter. The data obtained indicate that the main mechanism of DDT action includes disruption of thyroxine secretion by thyrocytes, but not inhibition of deiodinase activity and decrease of blood thyroid binding proteins.

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The impacts of organochlorines and other persistent pollutants on thyroid and metabolic health

Cited by 65 publications

References 247 publications

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Assessment of Pesticide Residues in Edible and Unhatched Chicken Eggs in Sharkia Province, Egypt

Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT

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