Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT

Yaglova, N. V.; Yaglov, V. V.

doi:10.18097/pbmc20146006655

Cited by 3 publications

(1 citation statement)

References 16 publications

(19 reference statements)

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“…Alterations of thyroid hormone secretion after long-term exposure to low doses of DDT through disruption of thyroxine secretion by thyrocytes have been reported. The DDT treatment in a low dose may induce similar changes observed during the development of hypothyroidism in conditions of iodine deficiency ( 30 , 31 ).…”

Section: Methodsmentioning

confidence: 85%

Primordial and Primary Preventions of Thyroid Disease

Azizi¹,

Mehran²,

Hosseinpanah³

et al. 2017

Int J Endocrinol Metab

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BackgroundPrimordial and primary preventions of thyroid diseases are concerned with avoiding the appearance of risk factors, delaying the progression to overt disease, and minimizing the impact of illness.SummaryUsing related key words, 446 articles related to primordial and primary, preventions of thyroid diseases published between 2001-2015 were evaluated, categorized and analyzed. Prevention and elimination of iodine deficiency are major steps that have been successfully achieved and maintained in many countries of the world in last 2 decades. Recent investigations related to the effect of cigarette smoking, alcohol consumption, and autoimmunity in the prevention of thyroid disorders have been reviewed.ConclusionsThe cornerstone for successful prevention of thyroid disease entails timely implementation of its primordial and primary preventions, which must be highly prioritized in related health strategies by health authorities.

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Section: Methodsmentioning

confidence: 85%

Primordial and Primary Preventions of Thyroid Disease

Azizi¹,

Mehran²,

Hosseinpanah³

et al. 2017

Int J Endocrinol Metab

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show abstract

Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny

et al. 2018

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Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.

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Thyroid nodules and thyroid autoimmunity in the context of environmental pollution

Benvenga

Antonelli

Vita

2015

Rev Endocr Metab Disord

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Evidence suggests that in most industrialized countries autoimmune disorders, including chronic lymphocytic thyroiditis, are increasing. This increase parallels the one regarding differentiated thyroid cancer, the increment of which is mainly due to the papillary histotype. A number of studies have pointed to an association between chronic lymphocytic thyroiditis and differentiated thyroid cancer. The upward trend of these two thyroid diseases is sustained by certain environmental factors, such as polluting substances acting as endocrine disrupting chemicals. Herein we will review the experimental and clinical literature that highlights the effects of environmental and occupational exposure to polluting chemicals in the development of autoimmune thyroid disease or differentiated thyroid cancer. Stakeholders, starting from policymarkers, should become more sensitive to the consequences for the thyroid resulting from exposure to EDC. Indeed, the economic burden resulting from such consequences has not been quantified thus far.

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Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT

Cited by 3 publications

References 16 publications

Primordial and Primary Preventions of Thyroid Disease

Primordial and Primary Preventions of Thyroid Disease

Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny

Thyroid nodules and thyroid autoimmunity in the context of environmental pollution

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