Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny

Yaglova, N. V.; Sledneva, Yu. P.; Назимова, С. В.; Обернихин, С. С.; Yaglov, V. V.

doi:10.1007/s10517-018-4005-1

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…The female compared to the male brain may therefore be more vulnerable to the effects of maternal thyroid hormone deficiency in early gestation. Further evidence supporting sex‐specific differences in the effects of maternal thyroid function, is that females are more likely to have thyroid abnormalities in clinical and basic neuroscience studies . Moreover, bipolar disorder is more prominent in females .…”

Section: Discussionmentioning

confidence: 99%

The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring

2019

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Objectives Higher rates of thyroid conditions are reported in individuals with bipolar disorder. However, no study to date has considered whether maternal thyroid conditions during pregnancy are associated with offspring risk of bipolar disorder, even though the fetus exclusively relies on maternal thyroid hormones through the early second trimester. We therefore examined the association between offspring bipolar disorder and serologically documented maternal thyroid conditions. Methods The study was based on a nested case‐control design that utilized data from the Child Health and Development Study, a birth cohort that enrolled pregnant women from 1959 to 1966. Eighty‐five cases with DSM‐IV‐TR were ascertained and matched to controls (1:2) by date of birth, sex, gestational timing of the serum draws, and residence in Alameda County the first year receiving treatment. Archived prenatal maternal serum drawn during early to mid‐gestation was used to measure two thyroid hormones, free thyroxine (fT4) and thyroid stimulating hormone (TSH). Subclinical and clinical hypothyroxinemia, hypothyroidism, and hyperthyroidism were determined based on standard methods. Results Exposure to maternal hypothyroxinemia was associated with a five‐fold increased risk of offspring bipolar disorder with psychotic features, but not without psychotic features. In stratified analysis, female offspring demonstrated increased risk for bipolar disorder with exposure to maternal hypothyroxinemia. No significant association was found between maternal hypothyroidism and offspring bipolar disorder. Conclusions These findings suggest that prenatal thyroid hormone deficiency, particularly a thyroid condition marked by low levels of thyroxine, may be an important developmental mechanism related to the risk of bipolar disorder with psychotic features.

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Section: Discussionmentioning

confidence: 99%

The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring

2019

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“…The transportation of iodide to thyroid cells is mediated by NIS, a protein located on the basolateral membranes of thyroid cells as well as cells of salivary glands, gastric mucosa, and renal cells [ 36 , 37 ]. Some chemicals such as perchlorates or dichlorodiphenyltrichloroethane have been shown to inhibit NIS and thyroid function [ 14 , 38 ]. The reduction in blood NIS levels is usually associated with the diminished production of thyroid hormones, and the restoration of NIS expression positively influences thyroid gland activity [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid dysfunction has multifactorial etiology and results from iodine deficit, exposure to negative occupational factors, and genetic predisposition. The thyroid is very sensitive to environmental and anthropogenic hazards, especially to endocrine-disrupting chemicals and ionizing radiation [ 14 , 15 , 16 , 17 , 18 ]. Therefore, the elucidation of the role of deuterium content in the function of the hypothalamic–pituitary–thyroid axis could also reveal some mechanisms of preventing or correcting thyroid dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Shifts in Deuterium Supply Similarly Change Physiology of the Pituitary–Thyroid Axis, but Differentially Influence Na+/I− Symporter Production

Yaglova

Обернихин

Timokhina

et al. 2023

IJMS

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Deuterium, a stable isotope of hydrogen, is abundant in organisms. It is known to produce various biological effects. However, its impact in thyroid hormone synthesis and secretion is poorly studied. The aim of this investigation was to evaluate the dynamics of thyroid hormones and pituitary thyroid-stimulating hormone secretion during bilateral shifts in deuterium supply and assess a possible role of the Na+/I− symporter (NIS), the main iodide transporter, in altered thyroid function. The experiment was performed on adult male Wistar rats, which consumed deuterium-depleted ([D] = 10 ppm) and deuterium-enriched ([D] = 500,000 ppm) water for 21 days. The assessment of total thyroxine and triiodothyronine and their free fractions, as well as thyroid-stimulating hormone in blood serum, revealed the rapid response of the thyroid gland to shifts in the deuterium/protium balance. The present investigation shows that the bilateral changes in the deuterium body content similarly modulate thyroid hormone production and functional activity of the pituitary gland, but the responses of the thyroid and pituitary glands differ. The response of the thyroid cells was to increase the synthesis of the hormones and the pituitary thyrotropes, in order to reduce the production of the thyroid-stimulating hormone. The evaluation of NIS serum levels found a gradual increase in the rats that consumed deuterium-enriched water and no differences in the group exposed to deuterium depletion. NIS levels in both groups did not correlate with thyroid hormones and pituitary thyroid-stimulating hormone production. The data obtained show that thyroid gland has a higher sensitivity to shifts in the deuterium body content than the hypothalamic–pituitary complex, which responded later but similarly in the case of deuteration or deuterium depletion. It indicates a different sensitivity of the endocrine glands to alterations in deuterium content. It suggests that thyroid hormone production rate may depend on deuterium blood/tissue and cytosol/organelle gradients, which possibly disturb the secretory process independently of the NIS.

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“…Endocrine activity of DDT has the potential to cause numerous adverse outcomes, including the disruption of several endogenous physiological processes [ 88 ]. In this way, low perinatal DDT doses have been associated with more pronounced hypothyroidism in female rats after exposure to DDT [ 89 ]. Hypothyroidism is correlated with decreased thermogenesis, decreased metabolic rate, and it has also been shown to correlate with a higher BMI and a higher prevalence of obesity in experimental animals and humans [ 90 , 91 , 92 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

Pinos

Carrillo

Merchán

et al. 2021

IJERPH

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In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.

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Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny

Cited by 6 publications

References 7 publications

The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring

The association of serologically documented maternal thyroid conditions during pregnancy with bipolar disorder in offspring

Bilateral Shifts in Deuterium Supply Similarly Change Physiology of the Pituitary–Thyroid Axis, but Differentially Influence Na+/I− Symporter Production

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review

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