Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Horváthová, Mira; Jahnová, E; Palkovičová, Ľubica; Trnovec, T.; Hertz‐Picciotto, Irva

doi:10.3109/1547691x.2011.615767

Cited by 15 publications

(13 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Higher 6-month infant concentrations of PCB-153 and DDE (dichlorodiphenyldichloroethylene) were strongly associated with lower 6-month BCG-specific antibody levels [24], and higher maternal and infant PCB concentrations have been associated with a reduced volume of the infant thymus, the site of T-cell maturation [25]. Moreover, early-life environmental PCB exposure was associated with fluctuations in major lymphocyte subsets [26], and affected the dynamics of cell surface lymphocyte receptor expression [27]. Overall, previous studies provide compelling evidence of the detrimental effects of exposure to environmental toxicants on the immune system, including immune cell counts, cytokine responses, and levels of specific antibodies [28].…”

Section: Introductionmentioning

confidence: 99%

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Oulhote

Shamim

Kielsen

et al. 2017

Reproductive Toxicology

View full text Add to dashboard Cite

Background To explore possible markers of developmental immunotoxicity, we prospectively examined 56 children to determine associations between exposures to methylmercury and persistent organic pollutants since birth and the comprehensive differential counts of white blood cells (WBC) at age 5 years. Materials and methods Extended differential count included: neutrophils, eosinophils, basophils, lymphocytes (including T cells, NK cells, and B cells), and monocytes. Organochlorine compounds (OCs) including polychlorinated biphenyls (PCBs) and pesticides, five perfluoroalkyl substances (PFASs), and total mercury (Hg) were measured in maternal (n=56) and children’s blood at 18 months (n=42) and 5 years (n=56). We constructed latent functions for exposures at three different ages using factor analyses and applied structural equation models adjusted for covariates. Results Prenatal mercury exposure was associated with depleted total WBC, especially for lymphocytes, where a one standard deviation (SD) increase in the exposure was associated with a decrease by 23% SD (95% CI: −43, −4) in the cell count. Prenatal exposure to OCs was marginally associated with decreases in neutrophil counts. In contrast, the 5-year PFASs concentrations were associated with higher basophil counts (B= 46% SD, 95% CI: 13, 79). Significantly reduced subpopulations of lymphocytes such as B cells, CD4-positive T helper cells and CD4 positive recent thymic emigrants may suggest cellular immunity effects and dysregulation of T-cell mediated immunity. Conclusion Developmental exposure to environmental immunotoxicants appears to have different impacts on WBC counts in childhood.

show abstract

Section: Introductionmentioning

confidence: 99%

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Oulhote

Shamim

Kielsen

et al. 2017

Reproductive Toxicology

View full text Add to dashboard Cite

show abstract

“…Subsequent human exposure has been associated with toxic effects on various organs including the nervous, reproductive, and immunologic systems. The exposures to PCBs in a highly exposed Slovak population were associated with endocrine disorders (Radiková et al, 2008), diabetes (Ukropec et al, 2010), and reproductive (Plísková et al, 2005), neurological (Park et al, 2009, 2010), and hearing impairments (Trnovec et al, 2010), in addition to cancers (Pavúk et al, 2003, 2004, Bencko et al, 2009), and immunotoxicity (Horváthová et al, 2011a, b). Recent evidence suggests that exposure to some commonly encountered environmental contaminants, e.g.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: Indicator of disease and disorder development in humans

Ghosh

Mitra

Loffredo

et al. 2015

Environmental Research

View full text Add to dashboard Cite

Background and Aims Our earlier gene-expression studies with a Slovak PCBs-exposed population have revealed possible disease and disorder development in accordance with epidemiological studies. The present investigation aimed to develop an in vitro model system that can provide an indication of disrupted biological pathways associated with developing future diseases, well in advance of the clinical manifestations that may take years to appear in the actual human exposure scenario. Methods We used human PBMC (Primary Blood Mononuclear Cells) and exposed them to a mixture of human equivalence levels of PCBs (PCB-118,138,153,170,180) as found in the PCBs-exposed Slovak population. The microarray studies of global gene expression were conducted on the Affymetrix platform using Human Genome U133 Plus 2.0 Array along with Ingenuity Pathway Analysis (IPA) to associate the affected genes with their mechanistic pathways. High-throughput qRT-PCR Taqman Low Density Array (TLDA) was done to further validate the selected 6 differentially expressed genes of our interest, viz., ARNT, CYP2D6, LEPR, LRP12, RRAD, TP53, with a small population validation sample (n=71). Results Overall, we revealed a discreet gene expression profile in the experimental model that resembled the diseases and disorders observed in PCBs-exposed population studies. The disease pathways included Endocrine System disorders, Genetic disorders, Metabolic diseases, Developmental disorders, and Cancers, strongly consistent with the evidence from epidemiological studies. Interpretation These gene finger prints could lead to the identification of populations and subgroups at high risk for disease, and can pose as early disease biomarkers well ahead of time, before the actual disease becomes visible.

show abstract

“…Horváthová et al showed that environmental PCB exposure during early life was associated with fluctuations in the frequencies of major lymphocyte subsets in children, suggesting that PCB exposure elicits a postnatal immune response [47]. In addition, various studies have detected positive correlations between in utero PCB exposure, which is frequently associated with the consumption of fish, and the risk of a low birth weight [48,49].…”

Section: Primermentioning

confidence: 97%

Association of PCBs and allergies in children

Tsuji

Kawamoto

Koriyama

et al. 2015

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls

Cited by 15 publications

References 78 publications

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Transcriptional profiling and biological pathway analysis of human equivalence PCB exposure in vitro: Indicator of disease and disorder development in humans

Association of PCBs and allergies in children

Contact Info

Product

Resources

About