The impact of serum FSH and estradiol on postmenopausal osteoporosis related to time since menopause

Yoldemir, Tevfik; Erenus, Mithat; Durmuşoğlu, Fatih

doi:10.3109/09513590.2012.683066

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…In the Study of Women’s Health Across the Nation (SWAN), women who transitioned through menopause experienced a significantly higher rate of bone loss than women who remained premenopausal, independent of age [ 26 ]. In turn, a recent study suggests that time since menopause may have a stronger predictive value for low BMD in the lumbar and hip areas than did serum FSH or estradiol levels [ 27 ]. Data from the present study reinforces that idea, showing that women with more than 5 years since menopause had higher prevalence of osteoporosis, as well as lower BMD in all sites when compared to those with less time since menopause.…”

Section: Discussionmentioning

confidence: 99%

Associations between body composition and lifestyle factors with bone mineral density according to time since menopause in women from Southern Brazil: a cross-sectional study

et al. 2015

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BackgroundThe aim of this study was to investigate whether body composition, dietary pattern and habitual physical activity are associated with BMD according to time since menopause in women from Southern Brazil with no clinical evidence of disease.Methods99 participants were enrolled and anthropometry, body composition and BMD by dual energy x-ray absorptiometry, rest metabolic rate by indirect calorimetry, dietary pattern by semi quantitative food frequency questionnaire and habitual physical activity by pedometer were performed.ResultsMean age was 55.2 ± 4.9 years and mean time since menopause was 6.8 ± 1.0 years. Weight, BMI, lean and fat mass and RMR were higher in women with less than 5 years since menopause with normal versus low bone mass. No differences were found in the studied variables between participants with normal or low bone mass and more than 5 years of menopause. Women with > 5 years since menopause had higher prevalence of osteoporosis, as well as lower BMD in all sites when compared to those with less time since menopause. Calories, carbohydrate, protein, fat and micronutrients intake were similar between groups. When the sample was adjusted for time since menopause, the odds ratio (OR) for low bone mass was 5.21 (95 % CI 1.57–17.25, P = 0.004) for BMI <25 kg/m2, for lean mass <37.5 Kg an OR of 4.4 (95 % CI 1.64–11.80, P = 0.004, for fat mass <26.0 Kg an OR of 3.39 (95 % CI 1.29–8.85, P = 0.010) and for the intake of vitamin A < 700 mcg/day an OR of 3.00 (95 % CI 1.13–7.94, P = 0.012). Low meat and eggs intake or low protein intake did not influence the odds ratio for low bone mass.ConclusionIn this cross-sectional study with postmenopausal women with no clinical evidence of disease, time since menopause, low lean and fat mass were associated with low bone mass. Calories and macronutrients intake as well as habitual physical activity did not interfere with BMD, but participants were mostly sedentary. Further studies are needed in order to determine whether the adequate intake of specific food groups and the type of physical activity could attenuate the time since menopause impact on BMD.

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Section: Discussionmentioning

confidence: 99%

Associations between body composition and lifestyle factors with bone mineral density according to time since menopause in women from Southern Brazil: a cross-sectional study

et al. 2015

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“…This is an expression of the increasing domination of the resorption process over that of bone formation [ 11 ]. During the menopausal transition, a decline in ovarian activity and accompanying estrogen deficiency and increased follicle stimulating hormone (FSH), which overlaps with age-related changes, results in significantly increased bone turnover [ 12 , 13 , 14 ]. Bone loss increases two years before menopause and is at its highest level during the first 3 years of menopause, with losses reaching 3–5% annually [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kanadys

Barańska

Błaszczuk

et al. 2021

IJERPH

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This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their quality was evaluated according to Cochrane criteria. The levels of markers were evaluated in a total of 1114 women who ingested mean daily doses of 98.2 mg (30.9 to 300) of soy isoflavones for 3 to 24 months, in comparison to those of 1081 subjects who used a placebo. Ten, eighteen, eight, and fourteen comparison studies were finally selected for an estimation of the effects on osteocalcin (OC), bone alkaline phosphatase (BAP), pyridinoline (PYD), and deoxypyridinoline (DPD), respectively. A summary of the results of intervention was as follows: 4.16%, 95% CI: –7.72–16.04, p = 0.49 for OC; 5.50%, 95% CI: –3.81–14.82, p = 0.25 for BAP; –12.09%, 95% CI: –25.37–1.20, p = 0.07 for PYD; and –7.48%, 95% CI: –15.37–0.41, p = 0.06 for DPD. The meta-analysis of the included studies revealed some statistically insignificant observations that soy isoflavones intake is associated with a trend in increased levels of OC and BAP, as well as a trend in reduced levels of PYD and DPD. Soy isoflavones may have a beneficial effect on bone formation markers, but this requires extensive multi-center research.

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“…Estrogen has a direct effect on osteoblasts, osteoclasts, and osteocytes [19][20][21]. There are studies that reported postmenopausal osteoporosis is associated with decreasing serum levels of estrogen [22]. Moreover, it was reported that serum level of estradiol has a strong relationship with osteoporosis and BMD [23].…”

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confidence: 99%

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

et al. 2020

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BackgroundIn the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects.ObjectiveTo investigate the serum levels of bone turnover markers in elderly osteoporosis patients.MethodsThe serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal–Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS.ResultsLevels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (P = 0.003 and 0.009, respectively). Furthermore, PINP and B-ALP levels had the best area under the curve, sensitivity, and specificity for the discrimination between patients with osteoporosis and healthy individuals.ConclusionIn conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool.

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The impact of serum FSH and estradiol on postmenopausal osteoporosis related to time since menopause

Abstract: Our study showed that neither FSH nor E2 has a strong impact on postmenopausal BMD. However it appears that time since menopause has a weak non-significant association with postmenopausal osteopenia and osteoporosis.

Cited by 11 publications

References 28 publications

Associations between body composition and lifestyle factors with bone mineral density according to time since menopause in women from Southern Brazil: a cross-sectional study

Associations between body composition and lifestyle factors with bone mineral density according to time since menopause in women from Southern Brazil: a cross-sectional study

Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

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