The impact of receptor of advanced glycation end‐products polymorphisms on prostate cancer progression and clinicopathological characteristics

Abstract

The receptor for advanced glycation end products (RAGE) overexpression was suggested to be associated with prostate cancer development and poor prognosis. In this study, we focused on the correlations between the clinicopathological characteristics and susceptibility of prostate cancer and RAGE single‐nucleotide polymorphisms (SNPs). In 579 prostate cancer patients, the RAGE SNPs rs1800625, rs1800624, rs2070600 and rs184003 in patients with or without grade group upgrade were analysed with real‐time polymerase chain reaction. The results demonstrated that the prostate cancer patients who carried the RAGE SNPs rs2070600 ‘GA’ genotypic variants were significantly associated with lower risk to develop grade group upgrade. Moreover, patients with the RAGE rs1800625 ‘TC + CC’ genotypic variants were associated with higher risk of perineural invasion. In 343 prostate cancer patients who carried the RAGE rs1800625 ‘TC + CC’ genotype without grade group upgrade were correlated with higher risk of biochemical recurrence and perineural invasion. In the analysis of TCGA database, significant differences of the RAGE mRNA level were found between the normal controls and prostate cancer patients (p < 0.0001), and the pathologic stage N1 and N0 patients (p = 0.0027). The prostate cancer patients with high RAGE expression were associated with lower overall survival rate (p = 0.025). In conclusion, our results have revealed that the RAGE SNPs rs2070600 and rs1800625 were associated with the grade group upgrade of prostate cancer and clinical status. The RAGE polymorphisms may provide as a pivotal predictor to evaluate prostate cancer disease progression and prognosis.

The use of androgen deprivation therapy for prostate cancer and its effect on the subsequent dry eye disease: a population-based cohort study

“…Although the female is more vulnerable to the DED, the prevalence of DED in the male population still reached 5.65 percent in that study. 40 On the other hand, the prostate cancer is one of the most common cancers in the elderly male population 41 , 42 . According to a previous research, the prevalence of prostate cancer is above 30 per 100000 male in Asian region 43 .…”

Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

“… 23 We separated genome and DNA from leukocytes in venous blood samples via QIAamp DNA kits (Qiagen, Valencia, Valencia, CA, USA) based on the manufacture's instruction of DNA isolation. 24 Then, these isolated DNA was placed in a refrigerator with internal temperature of −20°C. Then genetic polymorphism of the five ADAM‐10 SNPs rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) and rs2054096 (A/T) were detected via the usage of ABI StepOne Real‐Time PCR System (Applied Biosystems, Foster City, California), and the ADAM‐10 SNPs were further evaluated and optimized by the application of SDS version 3.0 software.…”

“…The DNA extraction and analyses procedures in our study were similar to the methods in our previous research 23 . We separated genome and DNA from leukocytes in venous blood samples via QIAamp DNA kits (Qiagen, Valencia, Valencia, CA, USA) based on the manufacture's instruction of DNA isolation 24 . Then, these isolated DNA was placed in a refrigerator with internal temperature of −20°C.…”

“…23 We separated genome and DNA from leukocytes in venous blood samples via QIAamp DNA kits (Qiagen, Valencia, Valencia, CA, USA) based on the manufacture's instruction of DNA isolation. 24 Then, these isolated DNA was placed in a refrigerator with internal temperature of −20°C. Then genetic polymorphism of the five ADAM-10 SNPs rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) conclusions, the ADAM-10 SNP rs2305421 G allele is associated with the presence of OSCC, and the ADAM-10 SNP rs383902 TC+CC and ADAM-10 SNP rs653765 CT+TT correlates to large tumour size in specific conditions.…”

Role of TNFSF15 variants in oral cancer development and clinicopathologic characteristics

“… 49 The TCGA database was downloaded from cBioPortal, an open‐source software system used to visualize variant and gene expression data from TCGA (http://www.cbioportal.org/). 50,51 …”