Role of TNFSF15 variants in oral cancer development and clinicopathologic characteristics

Abstract

Tumour necrosis family superfamily (TNFSF) member 15 (TNFSF15), encoded by TNFSF15, regulates immune responses and inflammation. However, the roles of TNFSF15 single-nucleotide variants (SNVs; formerly SNPs) in oral cavity squamous cell carcinoma (OCSCC) remain unclear. This case-control study included 2523 participants (1324 patients with OCSCC [52.5%] and 1199 healthy controls [47.5%]). The effects of TNFSF15 rs3810936, rs6478108 and rs6478109 on cancer development and prognosis were analysed by real-time PCR genotype assay. The Genotype-Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) databases were used to validate our findings. The results demonstrated that the patients with altered TNFSF15 SNVs had poorer histological differentiation than did those with wild-type alleles.TNFSF15 SNVs were significantly associated with moderate-to-poor histological differentiation in univariate logistic regression. In the GTEx database, the expression of altered TNFSF15 SNVs in whole blood was lower than that of wild-type alleles.However, the expression of altered SNVs in the upper aerodigestive mucosa was higher than that of wild-type alleles. In the TCGA database, the patients with higher TNFSF15 expression had shorter overall survival than did those with lower TNFSF15 expression, especially for human papillomavirus-negative and advanced staging | 5453 LU et al.

A novel prognostic classification integrating lipid metabolism and immune co-related genes in acute myeloid leukemia

“…Tumor necrosis family superfamily member 15 (TNFSF15) promotes lymphatic metastasis by upregulating vascular endothelial growth factor-C in a lung cancer mouse model (32). Lu et al showed that increased TNFSF15 expression indicates worse prognosis in oral cancer (33).…”

Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

“… 10 About the field of genetics, numerous studies have shown that the single‐nucleotide polymorphism (SNP) may involve in the OSCC development. 11 , 12 , 13 , 14 , 15 …”

“…10 About the field of genetics, numerous studies have shown that the single-nucleotide polymorphism (SNP) may involve in the OSCC development. [11][12][13][14][15] A disintegrin and metalloproteinase domain-containing protein 10 (ADAM-10) belong to a group of transmembrane and secreted proteins and involves in the pathway of cell migration, cell adhesion, proteolysis and cell signalling. 16 In previous studies, the ADAM-10 is also associated with certain type of malignancies such as the prostate cancer and pancreatic cancer.…”

“…On the other hand, the existence of human papillomavirus (HPV) is a risk factor for OSCC and the HPV 16 species contributes to the majority of HPV‐related OSCC 10 . About the field of genetics, numerous studies have shown that the single‐nucleotide polymorphism (SNP) may involve in the OSCC development 11–15 …”

The impacts of MACC1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

“…Variations in a solitary nucleotide base of the DNA sequence, known as single nucleotide polymorphisms (SNPs), are present in the population at a frequency of at least 1% [27,28]. These genetic variations can result in amino acid substitutions that affect protein function and contribute to disease development [29][30][31]. For instance, the G allele of rs1990172 at MACC1 has been linked to significantly decreased overall survival in colorectal cancer, while heterozygous carriers of SNPs rs1990172 and rs975263 showed a significantly higher risk of disease relapse in hepatocellular carcinoma recurrence in liver transplant patients [32,33].…”