Potential impact of <i>ADAM‐10</i> genetic variants with the clinical features of oral squamous cell carcinoma

Chen, Yi‐Tzu; Lin, Chiao‐Wen; Chou, Ying‐Erh; Su, Shih‐Chi; Chang, Lun‐Ching; Lee, Chia-Yi; Hsieh, Ming‐Ju; Yang, Shun‐Fa

doi:10.1111/jcmm.17728

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…Variations in a solitary nucleotide base of the DNA sequence, known as single nucleotide polymorphisms (SNPs), are present in the population at a frequency of at least 1% [27,28]. These genetic variations can result in amino acid substitutions that affect protein function and contribute to disease development [29][30][31]. For instance, the G allele of rs1990172 at MACC1 has been linked to significantly decreased overall survival in colorectal cancer, while heterozygous carriers of SNPs rs1990172 and rs975263 showed a significantly higher risk of disease relapse in hepatocellular carcinoma recurrence in liver transplant patients [32,33].…”

Section: Introductionmentioning

confidence: 99%

The impacts of MACC1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

Chang,

Hung,

Chou

et al. 2023

J. Cancer

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Urothelial cell carcinoma (UCC) is a common malignancy of the urinary tract in Taiwan. Metastasis-Associated in Colon Cancer 1 (MACC1), a newly identified oncogene and regulator of the HGF/Met signaling pathway, has been shown to play a critical role in the development and progression of several types of cancer. Our study aims to investigate the impact of MACC1 gene polymorphisms on the clinicopathological features of patients with UCC. In this study, we included a total of 719 patients with UCC and 719 healthy controls. The genotyping of five MACC1 gene polymorphisms (rs1990172, rs975263, rs3095007, rs4721888, and rs3735615) was performed using real-time PCR with TaqMan assays. Our findings indicate that urothelial cancer patients with MACC1 rs3095007 A allele had a decreased risk of >T2 stage [Odds ratio (OR)=0.619, 95% CI=0.394-0.971, p=0.036] and lymph node invasion (OR=0.448, 95% CI=0.201-0.998, p=0.044). Additionally, these individuals were associated with longer relapse-free survival (p=0.007) and overall survival (p=0.028). In conclusion, our findings demonstrate that urothelial cancer patients with MACC1 (rs3095007) CA and AA genotypes have a lower risk of advanced T stage and lymph node metastasis. Additionally, these genotypes were associated with longer relapse-free survival and overall survival, highlighting the potential of these biomarkers as predictors of UCC prognosis.

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Section: Introductionmentioning

confidence: 99%

The impacts of MACC1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

Chang,

Hung,

Chou

et al. 2023

J. Cancer

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Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Chen

Lin

Chou

et al. 2023

J Cellular Molecular Medi

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A disintegrin and metalloproteinase domain‐containing protein 10 (ADAM‐10) involves in the tumour progression, but the impacts of single‐nucleotide polymorphism (SNP) of ADAM‐10 on oral squamous cell carcinoma (OSCC) remain unclear. The aim of this study was to investigate the influence of SNP of ADAM‐10 on the clinical features of OSCC in male Taiwanese. Five loci of ADAM‐10 SNPs including rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) and rs2054096 (A/T) were genotyped by TaqMan allelic discrimination in 1138 OSCC patients and 1199 non‐OSCC individuals. The ADAM‐10 SNP rs2305421 GG (AOR: 1.399, 95% CI: 1.045–1.874, p = 0.024) and G allele (AOR: 1.170, 95% CI: 1.012–1.351, p = 0.034) illustrated a significantly higher genotypic frequencies in the OSCC group compared to the distribution of the ADAM‐10 SNP rs2305421 AA wild type. In the subgroup analysis, the ADAM‐10 SNP rs383902 TC+CC was significantly correlated to tumour size larger than T2 in betel quid chewer (AOR: 1.375, 95% CI: 1.010–1.872, p = 0.043), while the ADAM‐10 SNP rs653765 CT+TT was significantly associated with tumour size larger than T2 in cigarette smoker (AOR: 1.346, 95% CI: 1.023–1.772, p = 0.034). The results from The Cancer Genome Atlas revealed highest ADAM‐10 mRNA level in T2 stage of current smokers with head and neck squamous cell carcinoma (HNSCC). In conclusions, the ADAM‐10 SNP rs2305421 G allele is associated with the presence of OSCC, and the ADAM‐10 SNP rs383902 TC+CC and ADAM‐10 SNP rs653765 CT+TT correlates to large tumour size in specific conditions.

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Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer

Yeh,

Chen,

Chou

et al. 2023

J Cellular Molecular Medi

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Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B‐AS1), is a long noncoding RNA that has been shown to act as a scaffold, sponge, or signal hub to promote carcinogenesis. Here, we attempted to assess the effect of CDKN2B‐AS1 single‐nucleotide polymorphisms (SNPs) on the susceptibility to OSCC. Five CDKN2B‐AS1 SNPs, including rs564398, rs1333048, rs1537373, rs2151280 and rs8181047, were analysed in 1060 OSCC cases and 1183 cancer‐free controls. No significant association of these five SNPs with the risk of developing OSCC was detected between the case and control group. However, while examining the clinical characteristics, patients bearing at least one minor allele of rs1333048 (CA and CC) were more inclined to develop late‐stage (stage III/IV, adjusted OR, 1.480; 95% CI, 1.129–1.940; p = 0.005) and large‐size (greater than 2 cm in the greatest dimension, adjusted OR, 1.347; 95% CI, 1.028–1.765; p = 0.031) tumours, as compared with those homologous for the major allele (AA). Further stratification analyses demonstrated that this genetic correlation with the advanced stage of disease was observed only in habitual betel quid chewers (adjusted OR, 1.480; 95% CI, 1.076–2.035; p = 0.016) or cigarette smokers (adjusted OR, 1.531; 95% CI, 1.136–2.063; p = 0.005) but not in patients who were not exposed to these major habitual risks. These data reveal an interactive effect of CDKN2B‐AS1 rs1333048 with habitual exposure to behavioural risks on the progression of oral cancer.

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Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Cited by 5 publications

References 40 publications

The impacts of MACC1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

The impacts of MACC1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer

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