The Impact of Radiation Therapy, Lymph Node Dissection, and Hormonal Therapy on Outcomes of Tissue Expander–Implant Exchange in Prosthetic Breast Reconstruction

Wang, Frederick; Peled, Anne Warren; Chin, Robin; Fowble, Barbara; Alvarado, Michael; Ewing, Cheryl A.; Esserman, Laura J.; Foster, Robert D.; Sbitany, Hani

doi:10.1097/prs.0000000000001866

Cited by 49 publications

(41 citation statements)

References 43 publications

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“…Impact of several adjuvant approaches on surgical outcomes after second stage in TE/implant reconstruction is the topic of a recent study (6). A large dataset of prospectively collected NSM TE/two-stage cases were analyzed, by means of multivariate analyses adjusting for several parameters, with a 26-month median follow-up after TE exchange for implant.…”

mentioning

confidence: 99%

Two-stage implant based breast reconstruction: should we always exchange the tissue expander for an implant right away?

Bernini¹,

Meattini²,

Casella³

2016

Gland Surg.

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mentioning

confidence: 99%

Two-stage implant based breast reconstruction: should we always exchange the tissue expander for an implant right away?

Bernini¹,

Meattini²,

Casella³

2016

Gland Surg.

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“…Among the studies with indirect data analysis, radiotherapy was the main factor associated with implant loss, which was shown in seven papers [20][21][22][23][24]27,30 . According to a metanalysis published in 2015, the relative risk of reconstructive surgery failure in irradiated patients is 2.58 (95% confidence interval -95%CI 1.86-3.57).…”

Section: Yii and Khoomentioning

confidence: 99%

Management of complications in reconstructive mammoplasties with prostheses: systematic review

Hassan¹,

Urban²

2017

Rev. Bras. Mastol. (Impr.)

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Objective: The aims of this study were to determine the main managements of surgical complications in reconstructive mammoplasties with prostheses through a systematic literature review, and to evaluate the effectiveness in preserving the reconstruction. The secondary objective was to analyze factors regarding prosthetic loss. Methods: We used the MedLine database through the following expressions: "breast cancer" or "breast neoplasm" or "breast and neoplasm" or "breast and cancer" and "implants complications" or "implants and complications". The reference period for these studies comprised January 2000 to July 2016. Results: Of the 856 articles found, seven were included to analyze the applied protocols. The rate of saved prostheses after stratification of complications and use of managements varied from 45 to 100%, depending on the degree of complication. Other 12 articles that evaluated the factors associated with prosthetic loss were secondarily chosen. Radiotherapy was considered the most frequent factor and was found in seven studies. The number of lost prostheses varied from 0.9 to 22.7% in such studies. Conclusion: There is still no agreement on how to manage complications of reconstructive mammoplasties with prostheses. The decision remains a challenge, and therefore surgeons need to know the possible conducts in order to establish the most appropriate treatment.KEYWORDS: Breast cancer; mastectomy; mammaplasty; breast implantation. ABSTRACT RESUMOObjetivos: O objetivo principal deste estudo foi determinar, por meio de revisão sistemática da literatura, as principais condutas nas complicações cirúrgicas de mastectomias reconstruídas com próteses, bem como avaliar a eficácia em preservar a reconstrução. O objetivo secundário foi analisar fatores relacionados à perda da prótese. Métodos: Foi empregado o banco de dados do MedLine, utilizando as expressões: breast cancer, ou breast neoplasm ou breast and neoplasm ou breast and cancer e implants complications ou implants and complications. O período de referência desses estudos foi de janeiro de 2000 até julho de 2016. Resultados: Dos 856 artigos encontrados, 7 foram incluídos para análise dos protocolos de condutas aplicados. A taxa de próteses salvas após estratificação das complicações e aplicação das condutas variou de 45 a 100%, a depender do grau de complexidade. Foram selecionados, secundariamente, outros 12 artigos que avaliaram fatores associados à perda da prótese. A mais frequente foi a radioterapia com 7 estudos. O número de próteses perdidas variou entre 0,9 e 22,7% nesses estudos. Conclusão: Ainda não existe unanimidade no manejo das complicações de mastectomias reconstruídas com próteses. Portanto, a decisão permanece desafiadora e o cirurgião necessita conhecer as possíveis condutas para definir a mais apropriada. PALAVRAS-CHAVE:Câncer de mama; mastectomia; reconstrução da mama; implante de mama. REVIEW ARTICLEMastology, 2017;27(2):156-63 157Management of complications in reconstructive mammoplasties with prostheses: systematic review

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“…The available options include tamoxifen, aromatase inhibitors, and fulvestrant (11)(12)(13)(14)(15)(16). A prospective randomized trial performed in 1995, comparing modified radical mastectomy to hormone therapy followed by modified radical mastectomy found that there was no significant difference in the risk of complications and that immediate breast reconstruction was not an independent predictor of complications (17).…”

Section: Hormonal Therapymentioning

confidence: 99%

“…The optimal timing of radiotherapy and breast reconstruction is still a subject of debate (11). Patients receiving the alloplastic prosthesis, form a distinct group than those treated with autologous tissue reconstruction.…”

Section: Radiation Therapymentioning

confidence: 99%

Impact of different type of cancer treatment on the effectiveness of breast reconstruction

et al. 2016

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For women undergoing mastectomy as part of their breast cancer treatment, breast reconstruction is an important part of therapy. However, neoadjuvant, adjuvant treatments as well as other patient-related factors can compromise the results of breast reconstruction techniques. In this article we have reviewed current approaches to the management of complications and risks that neoadjuvant and adjuvant therapies pose on breast reconstruction after mastectomy for breast cancer. Non-treatment related factors influencing reconstruction techniques were reviewed as well.

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The Impact of Radiation Therapy, Lymph Node Dissection, and Hormonal Therapy on Outcomes of Tissue Expander–Implant Exchange in Prosthetic Breast Reconstruction

Abstract: Therapeutic, III.

Cited by 49 publications

References 43 publications

Two-stage implant based breast reconstruction: should we always exchange the tissue expander for an implant right away?

Two-stage implant based breast reconstruction: should we always exchange the tissue expander for an implant right away?

Management of complications in reconstructive mammoplasties with prostheses: systematic review

Impact of different type of cancer treatment on the effectiveness of breast reconstruction

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