Impact of different type of cancer treatment on the effectiveness of breast reconstruction

Abstract

For women undergoing mastectomy as part of their breast cancer treatment, breast reconstruction is an important part of therapy. However, neoadjuvant, adjuvant treatments as well as other patient-related factors can compromise the results of breast reconstruction techniques. In this article we have reviewed current approaches to the management of complications and risks that neoadjuvant and adjuvant therapies pose on breast reconstruction after mastectomy for breast cancer. Non-treatment related factors influencing reconstruction techniques were reviewed as well.

A Multicenter Analysis Examining Patients Undergoing Conversion of Implant-based Breast Reconstruction to Abdominally based Free Tissue Transfer

“…A history of smoking or diabetes was not directly related to the severity of implant failure in our study. However, these are well-established risk factors for surgical complications in general, [8][9][10][11][12][13][14] and should be considered before proceeding down the implant-based reconstruction pathway when tissue options are available. In future studies, it would be ideal to make matched comparisons between successful and failed breast implant reconstruction to establish true predictors of breast implant failure.…”

“…Although studies have shown that increased body mass index (BMI), smoking, and radiation are associated with more complications in implant-based reconstruction, characterization of breast implant failures and subsequent tissue salvages have been limited due to the small sample sizes in these studies. [8][9][10][11][12][13][14] When implant-based reconstruction fails, one option is to remove the implant and perform tissue flap reconstruction as a salvage procedure. It is unknown how frequently this occurs or if it is associated with success rates similar to primary flap reconstruction.…”

Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014

“…Previous analyses have identified several variables that are significantly associated with breast‐reconstruction technique. These include age, BMI, tobacco use, radiotherapy, chemotherapy, and DM . Studies have assessed the relation between these factors and breast‐reconstruction technique.…”

“…These include age, BMI, tobacco use, radiotherapy, chemotherapy, and DM. 8,32,33 Studies have assessed the relation between these factors and breast-reconstruction technique. Radiotherapy is particularly well studied.…”

Características Sociodemográficas E Reprodutivas De Mulheres Com Câncer De Mama

“…Acredita-se que as terapias adjuvantes possam agravar estas disfunções. Existem diversos efeitos colaterais sistêmicos conhecidos destas terapias, como, por exemplo, fibrose após a radioterapia, neuropatia periférica induzida pela quimioterapia e sintomas de fadiga em decorrência da hormonioterapia (LÔBO et al, 2014;SZLOCH et al, 2016). No entanto, a literatura ainda é escassa quanto à ação destas sobre a função do complexo do membro superior, especialmente em relação à força muscular.…”