The impact of ovarian stimulation protocol on oocyte quality, subsequent in vitro embryo development, and pregnancy after transfer to recipients in Eld's deer ( Rucervus eldii thamin )

Thongphakdee, Ampika; Berg, D.K.; Tharasanit, Theerawat; Thongtip, Nikorn; Tipkantha, Wanlaya; Punkong, Chainarong; Tongthainan, Daraka; Noimoon, Sakhon; Maikeaw, Umaporn; Kajornklin, Nudthakamol; Siriaroonrat, Boripat; Comizzoli, Pierre; Kamolnorranath, Sumate

doi:10.1016/j.theriogenology.2016.12.021

Cited by 11 publications

(6 citation statements)

References 53 publications

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“…The possibility to recover oocytes from deer and to evaluate their in vitro maturation (IVM) and subsequent developmental competence by in vitro fertilization (IVF) or parthenogenetic activation have been object of several investigations. In this regard, studies have been performed in red deer ( Cervus elaphus ) (Beaumont, Berg, & Asher, 2004; Berg, Thompson, & Asher, 2002b; Berg, Thompson, Peterson, & Asher, 2008; Garde et al., 2006), wapiti ( Cervus elaphus canadensis ) (Pollardl, Bringans, & Buckrell, 1995), fallow deer ( Dama dama ) (Zomborszky, Szabari, Kangyalics, & Tóth, 2004), white‐tailed deer ( Odocoileus virginianus ) (Siriaroonrat et al., 2010), Eld's deer ( Panolia eldii ) (Thongphakdee et al., 2017), sika deer ( Cervus nippon ) (Yin et al., 2013) and Iberian red deer ( Cervus elaphus hispanicus ) (García‐Álvarez et al., 2011).…”

Section: Introductionmentioning

confidence: 99%

Post‐mortem recovery, in vitro maturation and fertilization of fallow deer (Dama dama, Linnaeus 1758) oocytes collected during reproductive and no reproductive season

Uccheddu

Pintus

Garde

et al. 2020

Reprod Domestic Animals

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In recent decades, concern about nature conservation has grown rapidly as a consequence of accelerating rates of natural habitat loss, fragmentation and degradation that have resulted in the extinction of several species (Haddad et al., 2015). Assisted reproductive techniques (ARTs) and genetic rescue banks (GRBs) are useful tools to cope with fragmentation of habitats and loss of genetic variability (Zachos, 2011). In ungulates, ARTs' application could permit a more rapid expansion of populations than natural breeding (Andrabi &

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Section: Introductionmentioning

confidence: 99%

Post‐mortem recovery, in vitro maturation and fertilization of fallow deer (Dama dama, Linnaeus 1758) oocytes collected during reproductive and no reproductive season

Uccheddu

Pintus

Garde

et al. 2020

Reprod Domestic Animals

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show abstract

“…This has led to most fertility facilities to try to obtain at least 6 ova during the harvesting step. Numerous studies have examined how the FSH dose affects the follicles observed by ultrasound and the synchrony in their growth [ 10 , 22 , 23 ]. The changes in serum E2 and progesterone levels as well as ultrasound measurements of folliculometry [ 24 ] can serve as tools to predict the correct evolution of the stimulation; nevertheless, they remain insufficient.…”

Section: Discussionmentioning

confidence: 99%

Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

Camargo-Mattos¹,

García²,

Camargo-Diaz³

et al. 2020

J Ovarian Res

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Background: To determine if a modified ovarian sensitivity index (MOSI), based on initial follicular measurements and the initial follicle-stimulating hormone (FSH) dose, can predict the production of high-quality embryos for successful implantation during in vitro fertilization (IVF). Methods: This study consisted of two phases: 1) a retrospective study and 2) a prospective observational study. For the first phase, 363 patients charts were reviewed, of which 283 had embryos transferred. All women underwent a standardized antagonist-based IVF protocol. At the first follow-up (Day 3/4), the number and size of the follicles were determined. MOSI was calculated as ln (number follicles (≥6 mm) × 1000 / FSH initial dose). Afterward, the number and quality of the ova, embryo development, and the number and quality of the blastocysts were determined. Embryo implantation was confirmed by β-hCG. For the second phase, 337 IVF cycles were followed to determine MOSI's accuracy. Results: MOSI could predict the production of ≥4 high-quality embryos by Day 2 (AUC = 0.69, 95%CI:0.63-0.75), ≥2 blastocysts (AUC = 0.74, 95%CI:0.68-0.79), and ≥ 35% rate of blastocyst formation (AUC = 0.65, 95%CI:0.58-0.72). Using linear regression, MOSI was highly associated with the number of ova captured (β = 5.15), MII oocytes (β = 4.31), embryos produced (β = 2.90), high-quality embryos (β = 0.98), and the blastocyst formation rate (β = 0.06, p < 0.01). Using logistic regression, MOSI was highly associated with achieving ≥4 high-quality embryos (odds ratio = 2.80, 95%CI:1.90-4.13), ≥2 blastocysts (odds ratio = 3.40, 95%CI: 2.33-4.95), and ≥ 35% blastocysts formation rate (odds ratio = 1.96, 95%CI:1.31-2.92). This effect was independent of age, BMI, and antral follicle count. For implantation, MOSI was significantly associated with successful implantation (odds ratio = 1.79, 95%CI:1.25-2.57). For the prospective study, MOSI was highly accurate at predicting ≥6 high-quality embryos on Day 2 (accuracy = 68.5%), ≥6 blastocysts (accuracy = 68.0%), and a blastocyst formation rate of ≥35% (accuracy = 61.4%).

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“…The increasing use of sheep as an experimental model in reproductive studies of wild ruminant Artiodactyls and in human neonatology studies (3)(4)(5)(6)(7)(8)(9) makes the development of noninvasive hormonal monitoring techniques, such as the use of fecal samples, an important support tool for these studies. Thus, the results obtained in the present study demonstrate the possibility of endocrine monitoring of pregnant ewes submitted to experimental neonatology protocols, minimizing the deleterious effects of stress and highlighting this analysis as a tool to be used in wild sheep and tested in wild deer.…”

Section: Discussionmentioning

confidence: 99%

“…Sheep are also widely used in research as an experimental model for reproductive studies of wild ruminant artiodactyls and for human neonatology studies (3)(4)(5)(6)(7)(8)(9) . Thus, hormonal monitoring becomes essential for understanding reproductive physiology and monitoring gestational development.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Progesterone and Estrone Fecal Metabolites Throughout Gestation in Ewes

et al. 2019

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The aim of this study was to monitor the progesterone and fecal estrone metabolites throughout gestation in ewes correlating with the serum levels of these steroid hormones. Therefore, fecal and serum samples were collected from 5 weeks before mating and gestation until two weeks postparturition. Serum levels of progesterone and estrone and their fecal metabolites were measured by enzyme immunoassay. Serum and fecal hormonal patterns showed a significant correlation for both hormones (R = 0.8572, P < 0.001 for progesterone and R = 0.5893, P < 0.001 for estrone). The fecal progesterone metabolite levels showed significant increasing values among the three thirds of pregnancies, consistent with the serum levels and with the literature. Additionally, the prepartum peak of estrone in the fecal matrix was identified but without observation in the serum matrix due to the blood collection interval used. Therefore, this study demonstrated the viability of progesterone and estrone monitoring throughout gestation using fecal samples, making noninvasive longitudinal endocrine monitoring throughout gestation possible in this species. ResumoO objetivo deste estudo foi monitorar os níveis de metabólitos fecais de progesterona e estrona ao longo da gestação em ovelhas, correlacionando-os com os níveis séricos desses hormônios esteroides. Assim, amostras de fezes e sangue foram colhidas de cinco ovelhas no período pré-cobertura e durante a gestação, até duas semanas após o parto. Os níveis séricos de progesterona e estrona e de seus metabólitos fecais foram mensurados por enzimaimunoensaio. Os perfis hormonais séricos e fecais apresentaram correlação positiva significativa para os dois hormônios (R = 0,8572, P < 0,001 para progesterona e R = 0,5893, P < 0,001 para estrona). Os níveis de metabólitos fecais de progesterona apresentaram valores significativamente crescente entre os terços da gestação, corroborando com os níveis séricos e com os relatos da literatura. Adicionalmente, foi possível evidenciar o pico pré-parto de estrona na matriz fecal, porém sem registro na matriz sérica, provavelmente devido ao intervalo de coletas aplicado. Deste modo, este estudo demonstrou a AMARAL, R.S. et al.Cienc. anim. bras., Goiânia, v.20, 1-10, e-54208, 2019 viabilidade do monitoramento dos níveis de progesterona e estrona durante a gestação em ovinos utilizando amostras fecais, possibilitando monitoramento endócrino longitudinal não invasivo durante a gestação nessa espécie.

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The impact of ovarian stimulation protocol on oocyte quality, subsequent in vitro embryo development, and pregnancy after transfer to recipients in Eld's deer ( Rucervus eldii thamin )

Cited by 11 publications

References 53 publications

Post‐mortem recovery, in vitro maturation and fertilization of fallow deer (Dama dama, Linnaeus 1758) oocytes collected during reproductive and no reproductive season

Post‐mortem recovery, in vitro maturation and fertilization of fallow deer (Dama dama, Linnaeus 1758) oocytes collected during reproductive and no reproductive season

Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

Monitoring of Progesterone and Estrone Fecal Metabolites Throughout Gestation in Ewes

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