The impact of oral feeding on the severity of acute pancreatitis

Şahi̇n, Mustafa; Özer, Şükru; Vatansev, Celalettin; Aköz, Mehmet; Vatansev, Hüsamettin; Aksoy, Faruk; Dilsiz, Alaaddin; Yılmaz, Osman; Karademir, Mehmet Alp; Aktan, Meryem

doi:10.1016/s0002-9610(99)00204-4

Cited by 13 publications

(12 citation statements)

References 19 publications

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“…In an experimental study comparing early oral feeding with parental feeding in acute pancreatitis, it was reported that the histopathological changes in pancreatic tissue were less pronounced in the group of rats that were fed orally. 21 The result was explained by the hypothesis that oral feeding stimulates the production of enteral hormones (for example cholecystokinin, motilin, serotonin) and that might have positive effects on the inflammatory process in the pancreas such as trophic effect on the pancreatic tissue, increased pancreatic blood flow and gastrointestinal motility. In the present study, a direct measure such as collection of histological samples from pancreatic tissue was not possible from an ethical point of view in this patient group with mild acute pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery—A randomized clinical study

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery—A randomized clinical study

et al. 2007

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“…Some authors [20][21][22][23][24][25] described an experience of early enteral nutrition in severe acute pancreatitis using nasoenteral feeding. No patients developed relapse, hypertri-glyceridaemia or abnormalities of liver function, indicating that jejunal feeding can be used safely in acute pancreatitis without reactivation of the inflammatory process [26][27][28][29][30][31][32] . Our experimental results showed that the changes of serum glucose, calcium, and amylase did not reach statistical difference between two groups.…”

Section: Discussionmentioning

confidence: 99%

“…Kalfarentzos et al [17] , reported that EIN was well tolerated following acute pancreatitis, and was of comparable efficacy to PN. In fact, EIN did not deteriorate pancreatitic pathology, and might be safely adopted in dogs with acute pancreatitis [26][27][28][29][30][31][32] . Normally, it is known that secretion of CCK, SEC and gastrin is mainly located in the duodenum and jejunum.…”

Section: Discussionmentioning

confidence: 99%

Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis

Qin

Su²,

Hu³

et al. 2003

WJG

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AIM:To evaluate the effect of early intrajejunal nutrition (EIN) on the natural course, entero-hormone secretion and its efficacy on dogs with acute pancreatitis. METHODS:An acute pancreatitis model was induced by injecting 1 ml/kg of combined solution (2.5 % sodium taurocholate and 8 000-10 000 BAEE units trypsin/ml) into the pancreas via pancreatic duct. Fifteen dogs were divided into parenteral nutrition (PN) group and EIN group. Two groups were isonitrogenous and isocaloric. EIN was used at postoperative 24 h. Serum glucose, calcium, amylase and lysosomal enzymes were determined before and 1, 4, 7 d after acute pancreatitis was induced. All the dogs were injected 50 uCi RESULTS:There was no difference between two groups in the contents of serum calcium, amylase and lysosomal enzymes, 125 I-BSA index of pancreas/muscle and pancreas/ blood and PPS. The contents of CCK and gastrin in EIN were higher than those in PN group at 60 and 120 min (P<0.05). The content of SEC post-infusion of nutrition solution was higher than that of pre-infusion of nutrition solution in both groups, and only at 60 min SEC in EIN group was higher than that in PN group. The content of gastrin in EIN was higher than that in PN group at 120 and 180 min (P<0.05). CONCLUSION: EIN does not stimulate entero-hormone and pancreatic juice secretion, and enzyme-protein synthesis and release. EIN has no effect on the natural course of acute pancreatitis.Qin HL, Su ZD, Hu LG, Ding ZX, Lin QT. Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis.

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“…It has been shown that when probiotics supplemented early enteral nutrition they reduced the septic complications in acute pancreatitis (Dugas et al, 1999;Oláh et al, 2002a, b). Several advantages of enteral feeding over parenteral feeding have been demonstrated but no experimental study has documented the histopathologic effects of probiotics in acute pancreatitis (Sahin et al, 1999;Qin et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effects of probiotics on the severity of experimental acute pancreatitis

et al. 2005

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Objective: This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis. Design: Experimental study. Setting: Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital. Subjects:A total of 50 Wistar rats were randomly divided into five groups. Interventions: Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale. Results: The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4. Conclusions: We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis. Sponsorship: None.

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The impact of oral feeding on the severity of acute pancreatitis

Cited by 13 publications

References 19 publications

Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery—A randomized clinical study

Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery—A randomized clinical study

Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis

Effects of probiotics on the severity of experimental acute pancreatitis

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