The impact of obesity on the development and progression of rheumatoid arthritis

Finckh, Axel; Turesson, Carl

doi:10.1136/annrheumdis-2014-205741

Cited by 42 publications

(29 citation statements)

References 29 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity has turned into a major global health concern 25,26 and it is believed to be associated with a number of chronic illnesses. 26 As described above, adipose tissue poses an immunodulating impact on RA, however, the exact mechanism remains increasingly unclear. 27 Hence we investigated retrospectively the occurrence of obesity in RA patients and its association with disease activity.…”

Section: Resultsmentioning

confidence: 99%

“…16 All in all, the above results highlight that high BMI is linked to a RA state known to have persistent pain and poor patient reported prognosis and presumably less responsive to treatment, while low BMI, on the other hand, is characterized by progressive joint damage. 26 There were some weak points in our study; it was a retrospective cross-sectional study, and the sample size was relatively small. Furthermore, the selection of cases was not through random sampling, and Conclusion certainly, there was selection bias.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Younis¹,

Al-Bustany²

2017

ZJMS

View full text Add to dashboard Cite

Methods: One hundred twenty patients with rheumatoid arthritis who were regularly visiting Rizgary Teaching Hospital in Erbil were included in a cross-sectional study using specially designed mixed questionnaire. Body mass index and waist circumferences were measured, and their association with disease activity score 28 (DAS28) and clinical disease activity index (CDAI) were estimated. Furthermore, we evaluated their association with positive latex test. Results: There was increased frequency of obesity in rheumatoid arthritis patients, and there was a positive association between body mass index and waist circumference with disease activity measured by DAS28 and CDAI (P <0.001). There was no significant association between obesity and latex positivity which has been assessed separately for males and females (P = 0.898 and 0.086, respectively). Conclusion: Obesity is frequently found in rheumatoid arthritis patients. It is associated with higher disease activity, but not with the latex positivity in these patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Younis¹,

Al-Bustany²

2017

ZJMS

View full text Add to dashboard Cite

show abstract

“…Behavioral measures of nociception were evaluated at days 0, 1,5,8,12,15,19,22, and 26 after the first CFA injection. Spontaneous behavioral measures of arthritic joint pain including number of flinches and time spent guarding the affected extremity were quantified during a 5-min period as described previously (20,26,27).…”

Section: Evaluation Of Cfa-induced Nociceptive Behavioral Responsesmentioning

confidence: 99%

High‐fat diet exacerbates pain‐like behaviors and periarticular bone loss in mice with CFA‐induced knee arthritis

Loredo-Pérez¹,

Montalvo-Blanco²,

Hernández-González³

et al. 2016

Obesity

View full text Add to dashboard Cite

Objective: Our aim was to quantify nociceptive spontaneous behaviors, knee edema, proinflammatory cytokines, bone density, and microarchitecture in high-fat diet (HFD)-fed mice with unilateral knee arthritis. Methods: ICR male mice were fed either standard diet (SD) or HFD starting at 3 weeks old. At 17 weeks, HFD and SD mice received intra-articular injections either with Complete Freund's Adjuvant (CFA) or saline into the right knee joint every 7 days for 4 weeks. Spontaneous pain-like behaviors and knee edema were assessed for 26 days. At day 26 post-first CFA injection, serum levels of IL-1b, IL-6, and RANKL were measured by ELISA, and microcomputed tomography analysis of knee joints was performed.Results: HFD-fed mice injected with CFA showed greater spontaneous pain-like behaviors of the affected extremity as well as a decrease in the weight-bearing index compared to SD-fed mice injected with CFA. Knee edema was not significantly different between diets. HFD significantly exacerbated arthritis-induced bone loss at the distal femoral metaphysis but had no effect on femoral diaphyseal cortical bone. HFD did not modify serum levels of proinflammatory cytokines. Conclusions: HFD exacerbates pain-like behaviors and significantly increases the magnitude of periarticular trabecular bone loss in a murine model of unilateral arthritis.

show abstract

“…10,11 The reasons for this controversy very probably lie in the heterogeneity or weakness of the evaluation tools used both for body composition and the level of disease activity associated with RA, as well as weaknesses in the design and quality of the sample selection, all of which can be seen in the majority of the reports in which this question has been addressed. 10,11 The reasons for this controversy very probably lie in the heterogeneity or weakness of the evaluation tools used both for body composition and the level of disease activity associated with RA, as well as weaknesses in the design and quality of the sample selection, all of which can be seen in the majority of the reports in which this question has been addressed.…”

Section: Introductionmentioning

confidence: 99%

Association Between Body Composition and Inflammatory Activity in Rheumatoid Arthritis. A Systematic Review

Álvarez-Nemegyei

Buenfil-Rello

Pacheco‐Pantoja

2016

Reumatología Clínica (English Edition)

View full text Add to dashboard Cite

The impact of obesity on the development and progression of rheumatoid arthritis

Cited by 42 publications

References 29 publications

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

Prevalence of obesity in rheumatoid arthritis and its association with disease activity and latex positivity in a sample of patients in Erbil

High‐fat diet exacerbates pain‐like behaviors and periarticular bone loss in mice with CFA‐induced knee arthritis

Association Between Body Composition and Inflammatory Activity in Rheumatoid Arthritis. A Systematic Review

Contact Info

Product

Resources

About