The impact of nandrolone decanoate administration on ovarian and uterine tissues in rat: Luteinizing hormone profile, histopathological and morphometric assessment

Abstract

The study had been conducted to evaluate the effects of nandrolone decanoate (abused repeated doses) on female rat's ovary and uterus during administration and withdrawal. The study included 18 rats that were divided into control group (n = 6) and treated group (n = 12). The treated group was injected intramuscular (IM) with nandrolone decanoate (7 mg/kg body weight) for three consecutive days, for two weeks. The study stated that nandrolone decanoate increases the weights of body, ovary, and uterus. Moreover, it has a tendency of bringing upon modifications in the biochemical, histopathological, and morphological makeup of the female reproductive aspects. In conclusion, nandrolone decanoate has been identified as deleterious element for the female rats, and it is suggested that keen observations must be made on the human abusers to control and manage the possible pathologies.

Comparing the Effects of Consuming Propolis and Chicory for Eight Weeks and Resistance Training on Histopathological and Morphometric Changes of Uterine Tissue in Rats Treated With Testosterone Enanthate

“…Also, the uterine weight of the mice in the testosterone, chicory, and propolis groups was increased compared to the control group. In 2018, Saddick reported that uterine weight was a function of a pattern similar to that of mice during the AAS period, as the weight was increased during the period of consumption and decreased after withdrawal [26]. Other studies have also reported uterine weight gain [28,30].…”

“…The results demonstrated that the body weight of the mice in the sham, testosterone, chicory, and propolis groups was increased compared to the control group, even though the body weight of the sham, chicory, and propolis mice was lower than that of the testosterone group; this amount was not significant. Studies by Saddick (2018), Santos et al ( 2021), and Belardin et al ( 2014) have also shown an increase in the weight of mice consuming AAS [26][27][28]. AAS is often prescribed at supra-physiological doses from 3 mg/kg body weight to 25 mg/kg body weight to increase muscle mass [29].…”

Effect of Nandrolone Decanoate on Voice and Reproductivetissues in Wistar Rat: Histopathological and Morphometricassessmen

“…However, the focus of congestion found in the course of this research is something new which could be a result of increased venous drainage to the ovaries. (Saddick et al, 2018) Deduced that during the first and second weeks of treatment with ND, the presence of relatively less primary follicles was noticed while more corpora luteal was observed at the expense of ovarian follicles. The study may have suggested that ND could result in alteration in the normal anatomy of the ovary.…”

“…Long-and short-term administration of Nandrolone Decanoate revealed a significant decrease in the number of Leydig cells while the reduction of testosterone was peculiar to long term administration of Nandrolone Decanoate (Rahil et al, 2015). Intramuscular administration of Nandrolone Decanoate has led to improved body weight by the presence of relatively less primary follicles during treatment and withdrawal periods of 30 and 60 days respectively (Saddick et al, 2018). Persistent distressdecrease in ovarian weight, reduction of corpora lutea, enthrall, growing follicles and estrous cycle mutations which are associated with 30-day administration of Nandrolone Decanoate without complete recovery after 60-days of withdrawal observation (Simão et al, 2015).…”

Steroids in the Treatment of Chronic Diseases

“…Cancer cells have similar DNA and RNA (but not identical) to the cells of the organism from which they are originated [55]. AASs are commonly prescribed in the management of various pathological conditions including breast cancer, hereditary angioedema, renal insufficiency, and endometriosis [56]. The hormonal therapy for breast cancer includes tamoxifen, toremifene, and fulvestrant [57].…”