The Impact of Fructose on Renal Function and Blood Pressure

Kretowicz, Marek; Johnson, Richard J.; Ishimoto, Takuji; Nakagawa, Takahiko; Manitius, Jacek

doi:10.4061/2011/315879

Cited by 28 publications

(20 citation statements)

References 55 publications

(74 reference statements)

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“…It was suggested, that rodents show a lesser rise in serum UA in response to fructose due to the presence of uricase in their liver and hence lower serum UA than humans (Stavric et al, 1976). In our study, the consumption of the high-fat diet enriched with 20% of fructose for 3 weeks did not result in the rise of plasma UA, in both healthy and nephrectomized pigs, that is in contrast to results reported in previous studies (Kretowicz et al, 2011;Johnson et al, 2013b).…”

Section: Discussioncontrasting

confidence: 97%

“…For example, Gersch et al (2007) showed that administration of fructose to rats with reduced renal function (the remnant kidney model) can accelerate the progression of renal disease, resulting in worse proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis. Other authors reported no effect of low-fructose diet for a period of 6 weeks on renal function of humans with stable chronic kidney disease (Kretowicz et al, 2011). As mentioned, fructose can increase intracellular and circulating UA levels due to increased nucleotide turnover and synthesis, as well as due to stimulation UA synthesis from amino acid precursors, such as glycine (Johnson et al, 2013b).…”

Section: Discussionmentioning

confidence: 95%

“…It was reported that fructose can induce renal hypertrophy and tubulointerstitial disease, as well as increase serum uric acid level due to ATP depletion and increased purine destruction (Kretowicz et al, 2011;Johnson et al, 2013b). However, experimental data in the literature is contradictory.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

Mosiichuk¹,

Grujić²,

Woliński

et al. 2019

J. Anim. Feed Sci.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

Mosiichuk¹,

Grujić²,

Woliński

et al. 2019

J. Anim. Feed Sci.

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“…Increased total fructose consumption has been implicated in the obesity epidemic [4] and contributes to the rising frequency of cardiorenal metabolic syndrome (CRS)-associated insulin resistance, type 2 diabetes mellitus, and hypertension (Fig. 1) [5, 6]. Recent data from the third National Health and Nutrition Examination Survey (NHANES) indicate that consumption of sugar-sweetened beverages is significantly associated with plasma uric acid (UA) concentrations [7].…”

Section: Introductionmentioning

confidence: 99%

Fructose and Uric Acid: Is There a Role in Endothelial Function?

et al. 2014

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Population level data support that consumption of fructose and fructose-based sweeteners has dramatically increased and suggest that high dietary intake of fructose is an important factor in the development of the cardiorenal metabolic syndrome (CRS). The CRS is a constellation of cardiac, kidney and metabolic disorders including insulin resistance, obesity, metabolic dyslipidemia, high blood pressure, and evidence of early cardiac and kidney disease. The consequences of fructose metabolism may result in intracellular ATP depletion, increased uric acid production, oxidative stress, inflammation, and increased lipogenesis, which are associated with endothelial dysfunction. Endothelial dysfunction is an early manifestation of vascular disease and a driver for the development of CRS. A better understanding of fructose overconsumption in the development of CRS may provide new insights into pathogenesis and future therapeutic strategies.

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“…There is more than one explanation for decreasing the body weight in HFD consumption in this study. It is interesting that rats feed on HFD may not show an increase in overall body weight if it is not associated with diets high in fat [32]. Excessive consumption of fructose is accompanied by a decrease in body weight because of excessive muscle wasting and wastage of tissue protein due to renal failure.…”

Section: Discussionmentioning

confidence: 99%

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Rashwan

El-Beltagy

Saleh

et al. 2019

Beni-Suef Univ J Basic Appl Sci

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Background: One of the serious public health problems in the world is metabolic syndrome. It includes visceral obesity, dyslipidemia, insulin resistance, hyperglycemia, and hypertension. As a contributor to almost all the classic signs of metabolic syndrome, fructose was the ideal choice. There are certain shortcomings with existing drugs for insulin-resistant treatment. Plants still represent the main source of most available medicines. Cinnamaldehyde (CNA) is an active principle of Cinnamomum zeylanicum. Costunolide (CE) is natural sesquiterpene lactones, which is the main bioactive constituent of Saussurea lappa. The main aim of the present study is to investigate the effect of the synthetic antidiabetic agent (metformin) in comparison with natural constituents (cinnamaldehyde, costunolide) after developing a reliable model for insulin resistance by using high fructose diet (HFD). Results: It was found that HFD increased plasma glucose, insulin, glycosylated hemoglobin, HbA1c, serum total cholesterol, LDL-cholesterol, triglyceride, ALT, AST, creatinine, and uric acid. Moreover, HFD decreased hepatic reduced glutathione and superoxide dismutase levels. While oral administration of cinnamaldehyde and costunolide significantly decreased plasma glucose, HbA1c, total cholesterol, LDL-cholesterol, triglyceride, and increased level of hepatic reduced glutathione and superoxide dismutase activity. Also, cinnamaldehyde and costunolide restored the altered plasma levels of ALT, AST, creatinine, and uric acid to normal. Conclusions: The results of this experimental study showed that cinnamaldehyde and costunolide could be used as safe drugs for treating different abnormalities of metabolic syndrome.

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The Impact of Fructose on Renal Function and Blood Pressure

Cited by 28 publications

References 55 publications

Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

Fructose and Uric Acid: Is There a Role in Endothelial Function?

Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

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