Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Rashwan, Ayat S.; El-Beltagy, Marwa A.; Saleh, Sherif Y.; Ibrahim, Ibrahim A.

doi:10.1186/s43088-019-0025-9

Cited by 15 publications

(7 citation statements)

References 56 publications

(57 reference statements)

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“…Cinnamaldehyde in the form of cinnamon powder has also been shown to reduce glucose, total cholesterol, triglycerides, and LDL cholesterol levels in T2DM patients ( 70 ). Furthermore, cinnamaldehyde treatment reduced the serum levels of triglycerides, total cholesterol, c-LDL and elevated the c-HDL levels in high-fat diet rats ( 71 ). This evidence suggests the involvement of TRPA1 in lipid homeostasis.…”

Section: Trpa1 Channels In Metabolic Disordersmentioning

confidence: 99%

Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

et al. 2021

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Neuropsychiatric disorders (NPDs) are a huge burden to the patient, their family, and society. NPDs have been greatly associated with cardio-metabolic comorbidities such as obesity, type-2 diabetes mellitus, dysglycaemia, insulin resistance, dyslipidemia, atherosclerosis, and other cardiovascular disorders. Antipsychotics, which are frontline drugs in the treatment of schizophrenia and off-label use in other NPDs, also add to this burden by causing severe metabolic perturbations. Despite decades of research, the mechanism deciphering the link between neuropsychiatric and metabolic disorders is still unclear. In recent years, transient receptor potential Ankyrin 1 (TRPA1) channel has emerged as a potential therapeutic target for modulators. TRPA1 agonists/antagonists have shown efficacy in both neuropsychiatric disorders and appetite regulation and thus provide a crucial link between both. TRPA1 channels are activated by compounds such as cinnamaldehyde, allyl isothiocyanate, allicin and methyl syringate, which are present naturally in food items such as cinnamon, wasabi, mustard, garlic, etc. As these are present in many daily food items, it could also improve patient compliance and reduce the patients’ monetary burden. In this review, we have tried to present evidence of the possible involvement of TRPA1 channels in neuropsychiatric and metabolic disorders and a possible hint towards using TRPA1 modulators to target appetite, lipid metabolism, glucose and insulin homeostasis and inflammation associated with NPDs.

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Section: Trpa1 Channels In Metabolic Disordersmentioning

confidence: 99%

Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

et al. 2021

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“…Cin treatment on the other hand, reduced the toxic effect of TeA as evidenced in the present study. Earlier studies on the ameliorative effect of Cin have shown reduced body weight in obese male mice and rats that were fed a high-fat diet ( Zuo et al, 2017 ; Rashwan et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Preventive role of cinnamaldehyde against tenuazonic acid- and Freund’s adjuvant-induced histopathological and biochemical alterations in the mouse model

Kumari

Singh

2023

Front. Microbiol.

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IntroductionThis study was designed to assess the protective role of cinnamaldehyde (Cin) against the synergistic effect of tenuazonic acid (TeA) and Freund’s adjuvant on different organs of Swiss albino mice.MethodsTeA was administered singly and in combination with Freund’s adjuvant intra-peritoneally. The mice were divided into control (vehicle treated), mycotoxicosis-induced (MI) groups, and treatment groups. The route of administration of TeA was intra-peritoneal. The treatment group (FAICT) received Cin orally as a protective agent against TeA-induced mycotoxicosis. The effects on performance, differential leukocyte counts (DLC), and pathological measurements in eight organs (liver, lungs, kidney, spleen, stomach, heart, brain, and testis) were taken into consideration.ResultsThe body weight and feed consumption decreased significantly in the MI groups, which were reversed in the FAICT group. The necropsy observations revealed an increase in the relative organ-to-body weight percentage in the MI groups, which was restored to normal in the FAICT group. Freund’s adjuvant enhanced the effects of TeA on DLC. The antioxidant enzymes SOD and CAT decreased, while MDA increased in the MI groups. Caspase-3 activity was reduced in all organs and remained stable in the treatment group. TeA elevated the ALT concentration in the liver and kidneys and the AST in the liver, kidney, heart, and brain tissues. The oxidative stress induced by TeA in the MI groups was ameliorated in the treatment group. Histopathological observations consisted of NASH, pulmonary oedema and fibrosis, renal crystals and inflammation, splenic hyperplasia, gastric ulceration and cyst, cerebral axonopathy, testicular hyperplasia, and vacuolation in the MI groups. However, no such pathology was recorded in the treatment group.DiscussionsThus, it can be concluded that the toxicity of TeA was found to be enhanced when combined with Freund’s adjuvant. However, Cin exhibited promising protective effects against TeA + Freund’s adjuvant toxicity and reverted the pathological alterations caused by them. Additionally, this study emphasizes Freund’s adjuvant’s ability to increase mycotoxicity rather than just acting as an immunopotentiator.

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“…Metformin's augmentation of the lipid profile is due to the activation of AMPK in hepatic cells; as a result, Acetyl-CoA carboxylase (ACC) activity is lowered. [55].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

Kilany

Soliman

Marie

et al. 2022

Advances in Environmental and Life Sciences

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The aim of the research was to examine the effects of various antidiabetic agents in albino rats by the selection of two antidiabetic agents, one of which is chemical (metformin) and the other is a natural plant (Costus), and to investigate their possible beneficial effects on diabetes. A total of 36 normal male adults albino rats ( Sprague strain) were randomly assigned into six equal groups. Three of them were normal rats. The first normal group served as the control group. The second normal group received costus rhizome extract at a dose of 250 mg/ kg B. W. once a day for 30 days. The third normal group received metformin cure at a dose of 500 mg/ kg B. W. once a day for 30 days. The other three groups were diabetic rats that injected STZ (45 mg/ kg B.W. /i.p.). The first diabetic group served as control group. The second diabetic group received costus rhizome extract at a dose of 250 mg/ kg B. W. by oral gavage once a day for 30 days, the third diabetic group received metformin cure at a dose of 500 mg/ kg B. W. by oral gavage once a day for 30 days. Our results showed that metformin and hexane extract of costus sp. treated groups revealed enhancement and improvement of disturbance of liver functions, kidney functions, immunological parameters, antioxidant parameters and histopathology of the pancreas.

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Potential role of cinnamaldehyde and costunolide to counteract metabolic syndrome induced by excessive fructose consumption

Cited by 15 publications

References 56 publications

Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

Intersections in Neuropsychiatric and Metabolic Disorders: Possible Role of TRPA1 Channels

Preventive role of cinnamaldehyde against tenuazonic acid- and Freund’s adjuvant-induced histopathological and biochemical alterations in the mouse model

Antidiabetic Effect of Hexane Extract of Costus Speciosus and Metformin in Rats

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