The impact of diabetes mellitus on the course and outcome of pregnancy during a 5-year follow-up

Mitrović, Milena; Stojic, Sinisa; Tesic, Dragan; Popovic, Djordje S.; Rankov, Olivera; Naglić, Dragana Tomić; Paro, Jovanka Novaković; Pejin, Radoslav; Bulatovic, Sanja; Veljić, Mašsa Todorović; Zavišić, Branka Kovarev

doi:10.2298/vsp1410907m

Cited by 16 publications

(19 citation statements)

References 22 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Women with diabetes, especially type 1, have poorer pregnancy outcomes, as well as greater incidence of spontaneous abortions, pre-eclampsia, fetal macrosomia, preterm delivery, congenital anomalies and perinatal mortality. A study in this context showed a higher incidence of perinatal fetal morbidity (hypoglycemia, jaundice, respiratory distress syndrome) in the patients with type 1, type 2 and gestation diabetes than in the healthy controls [19]. Similar findings to our results were also reported in a study found that Maternal and neonatal outcomes for women with type 2 diabetes were worse than those for nondiabetic controls.…”

Section: Discussionsupporting

confidence: 92%

Untitled

2017

JDMDC

View full text Add to dashboard Cite

Background: Diabetes Miletus (DM) is a serious complex condition which can affect the entire body. DM that develops during pregnancy is known as gestational diabetes (GD), which carries health risks for both the mother and fetus. Therefore, the aim of this study was to assess the possible complications among pregnant diabetic patients (cases) compared to non-diabetic pregnant ladies (controls) in Sudan. Materials and Methods:This was prospective case-control study conducted in Sudan during the period from September 2014 to March 2015. Two hundreds individuals (100 were cases and 100 were controls) were investigated using different clinical and laboratory measures.Results: Clinical complications when compared to normal pregnant women (control group), diabetic pregnant women (case group) showed significant increase in incidence of persistent glycosuria (GU), urinary tract infection (UTI), hypertension, GD in previous pregnancy, abortion / stillbirth and asymptomatic bacteriuria (AB), (P value <0.001, 0.001, 0.001, 0.001, 0.030 and 0.007 respectively). GU (98% in cases versus 1% in controls), UTI (94% in cases versus 49% in controls), hypertension (23% in cases versus 1% in controls), GDM in Previous Pregnancy (98% in cases versus none in controls), abortion / stillbirth (14% in cases versus 5% in controls) and AB (53% in cases versus 34% in controls). Conclusion:Several complications are commonly associated with pregnant diabetic patients including; glycosuria (GU), urinary tract infection (UTI), hypertension and lipid profile disorders. Pregnant diabetic ladies should undergo more medical care and follow up than non-diabetics for early management of expected complications.

show abstract

Section: Discussionsupporting

confidence: 92%

Untitled

2017

JDMDC

View full text Add to dashboard Cite

show abstract

“…Moderately increased values of glycated hemoglobin are related with macrosomia and very high glycated hemoglobin values are related with IUGR [22]. However, in some clinical studies, despite the increased risk of fetal abnormalities, perinatal complications and perinatal morbidity, there was no direct correlation between some of those factors and glycated hemoglobin [15,23]. In vitro studies have shown that the growth-retarding and teratogenic effect of even lower doses of glucose and ketone bodies acting simultaneously, is greater than when each substance acted separately [24].…”

Section: Discussionmentioning

confidence: 99%

“…Untreated or uncontrolled diabetes type 1 results inter alia in ketoacidosis and hyperglycemia. The risk of spontaneous miscarriage, congenital malformations, stillbirth, fetal growth restriction, fetal macrosomia, preeclampsia, early mortality or preterm delivery is increased [15,16]. Pre-gestational diabetes affects also placental weight and function, causing placental circulatory disorders, vasculopathy and placental insufficiency [17].…”

Section: Discussionmentioning

confidence: 99%

Impact of experimental diabetes and chronic hypoxia on rat fetal body weight

et al. 2018

View full text Add to dashboard Cite

Objectives: The aim of the study is to determine the impact of the experimental diabetes and the chronic hypoxia on pregnancy development and rat fetal body weight. Material and methods:The experiment was performed on female Wistar rats. Animals were divided into the experimental groups. I -Controls, II -Untreated diabetes, III -Insulin-treated diabetes, IV -No diabetes with chronic hypoxia, V -Untreated diabetes and chronic hypoxia, VI -Insulin-treated diabetes and chronic hypoxia. Diabetes was induced in groups II, III, V and VI with intraperitoneal injection of streptozocin (STZ) at a dose of 40 mg/kg. Chronic hypoxia was induced by placing dams (groups IV, V and VI) in conditions of 10.5% oxygen and 89.5%. Insulin was administered subcutaneously at the dose of 9 IU/kg. Starting from the 6 th day after STZ injection and chronic hypoxia conditions animals were caged together for 12 hours for 3 consecutive days to ensure fertilization. On day 21 of gestation the animals were decapitated, the fetuses were removed and weighted.Results: Mean fetal body weight in separate groups were: I -5.38 g, II -6.04g, III -5.32g, IV-5.56 g, V -3.45 g, VI -6.23 g. Conclusions:Pre-existing type 1 diabetes does not affect fetal body weight compared to healthy newborn control rats. Prolonged hypoxia does not impact on fetal body weight. Chronic hypoxia during pregnancy complicated with untreated type 1 diabetes mellitus leads to significant reduction of fetal body weight. Insulin treatment reversed the detrimental effect of chronic hypoxia on fetal development.

show abstract

“…12 They also evaluated pregnancy outcomes in the patients with preexisting diabetes type 1 and the patients with gestational and diabetes type 2. Their study resulted that a higher incidence of perinatal fetal morbidity (hypoglycemia, jaundice, respiratory distress syndrome) in the patients with type 1, type 2 and GDM than in the healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…12 In present study all patients were treated with insulin and we compared antenatal ultrasound (amnion fluid index (AFI), umbilical doppler etc.) and peri and postnatal maternal and fetal outcomes in patients with GDM and pregestational DM including type 1 and 2.…”

Section: Discussionmentioning

confidence: 99%

Gestational diabetes mellitus is as innocent as you think?

Uysal¹,

Kütük²

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

The antenatal follow-up in diabetic pregnant women is important to control blood glucose levels, treat chronic complications and to monitor the fetus. In addition to routine pregnancy antenatal follow up, glucose impairment is the most focused issue to manage and identify the complications of pregnancy in GDM patients.It is well known that pregestational DM has higher congenital fetal malformations including caudal ABSTRACT Background: We aimed to compare fetal outcomes, fetal hypoxia, acidemia and maternal chracteristics including hemoglobin A1c, doppler indices between gestational diabetes mellitus (GDM) and pregestational diabetes mellitus (DM) among pregnant women treated with insulin. Methods: Data of pregnant patients with diagnosis of pregestational diabetes (type 1 and 2) and GDM who were treated with insulin (GDM A2 in White classification) was retrospectively collected and compared. Patients with active chronic systemic disease, multiple pregnancies, lost to follow up and detected fetal malformations were exluded. Maternal characteristics, umbilical doppler indices and amnion fluid index, gestational age at delivery, delivery characteristics (including vaginal delivery, or cesarean section) and newborn characteristics such as birth weight, Apgar score and umblical cord pH were all recorded. Results: A total of 130 patients (67 patients with GDM and 63 pregestational DM) were recruited to the study. There were no significant difference regarding type of delivery, fetal birth weight, umbilical cord Hb and gestational birth age. No other significant difference in frequency of low Apgar scores and fetal acidosis or metabolic acidosis were reported. HbA1c and blood glucose levels and insulin dosage were significantly statistically higher in pregestational group. Conclusions: The frequency of fetal distress parameters and poor fetal outcome were similar between groups although pregestaional diabetic patients had higher HbA1c rates. Therefore, patients with GDM (A2) should be followed up as closely as pregestational (overt) diabetic patients.

show abstract

The impact of diabetes mellitus on the course and outcome of pregnancy during a 5-year follow-up

Cited by 16 publications

References 22 publications

Untitled

Untitled

Impact of experimental diabetes and chronic hypoxia on rat fetal body weight

Gestational diabetes mellitus is as innocent as you think?

Contact Info

Product

Resources

About