The impact of cyclin D1 overexpression on the prognosis of bladder cancer: a meta-analysis

Abstract

BackgroundTo evaluate the relationship between cyclin D1 overexpression and bladder cancer prognosis.MethodsA systematic literature search up to July 27, 2013 was carried out in PubMed and Wanfang databases, and the references of retrieved articles were screened. The hazard ratios (HRs) and their 95% CIs were used to combine the data. Heterogeneity and publication bias were also evaluated.ResultsA total of 15 studies containing 2,591 cases were included. We found that increased cyclin D1 levels were significantly correlated with progression-free survival with a pooled HR estimate of 0.54 (95% CI: 0.32–0.92). There was a significant degree of heterogeneity (I2 = 93.8%, P <0.001). Moreover, subgroup analysis indicated that elevated cyclin D1 levels were significantly associated with overall survival in muscle-invasive bladder patients (HR: 0.95, 95% CI: 0.91–0.99), without a significant heterogeneity in the data (I2 = 0.0%, P = 0.456).ConclusionsIncreased cyclin D1 expression level detected by immunohistochemistry is associated with good progression-free survival for bladder cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings from our study.

Daidzein exerts anti-tumor activity against bladder cancer cells via inhibition of FGFR3 pathway

“…Cyclin D1 is a critical cell cycle regulatory protein, playing an important role in the G1/S transition through binding to cyclin-dependent kinase 4 (CDK4)to phosphorylate [23] and inactivate the retinoblastoma (Rb) protein [24]. Previous studies showed that increased CyclinD1 expression was associated with poor prognosis and decreased postoperative patient survival [25,26]. Additionally, a significant proportion of bladder cancer cases showed that over-expression of the c-Myc gene was relevant with bladder carcinogenesis as well [27][28][29].In this study, we detected Cyclin D1 and c-Myc expression levels under daidzein treatment.…”

Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta‐analysis

“…Several meta‐analysis articles have explored the prognostic role of CCND1 in breast cancer, gastric cancer, bladder cancer, lung cancer, and oral squamous cell carcinomas . However, no meta‐analysis for CCND2 or CCND3 has been conducted.…”

Urinary bladder cancer: biomarkers and target therapy, new era for more attention

“…18 Although the data regarding the prognostic value of cyclin D1 is equivocal, a subgroup analysis in a study of 150 BCa patients revealed that over expression is considered as a predictor for lower progression rate and eventually better survival. 19 Cox’s multivariate analysis selected cyclin D3 as an independent predictor of progression-free survival together with tumor size in patients with Ta/T1 BCa. 20 A study of protein levels of cyclin E and p27 levels in BCa demonstrated significantly improved survival associated with low protein expression.…”