The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling

Jacobs, Christine; Davis, Barclay R.; Rieger, Christopher J.; Francis, Justin; Saad, M.; Fyhrie, David P.

doi:10.1016/s0021-9290(99)00115-3

Cited by 61 publications

(21 citation statements)

References 11 publications

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“…These -FEA models have been shown to give accurate estimates of the apparent elastic moduli of cancellous bone. 10,12,16,22 A tissue modulus of 5 GPa was assumed for all specimens.…”

Section: Morphometric and Mechanical Analysismentioning

confidence: 99%

Increase in bone volume fraction precedes architectural adaptation in growing bone

Tanck

Homminga

Lenthe

et al. 2001

Bone

177

140

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In mature trabecular bone, both density and trabecular orientation are adapted to external mechanical loads. Few quantitative data are available on the development of architecture and mechanical adaptation in juvenile trabecular bone. We studied the hypothesis that a time lag occurs between the adaptation of trabecular density and the adaptation of trabecular architecture during development. To investigate this hypothesis we used ten female pigs at 6, 23, 56, 104, and 230 weeks of age. Three-dimensional morphological and mechanical parameters of trabecular bone samples from the vertebra and proximal tibia were studied using microcomputed tomography and micro-finite element analysis. Both bone volume fraction and stiffness increased rapidly in the initial growth phase (from 6 weeks on), whereas the morphological anisotropy started increasing only after 23 weeks of age. In addition, the anisotropy reached its highest value much later in the development than did bone volume fraction. Hence, the alignment of trabeculae was still progressing at the time of peak bone mass. Therefore, our hypothesis was supported by the time lag between the increase in trabecular density and the adaptation of the trabecular architecture. The rapid increase of bone volume fraction in the initial growth phase can be explained by the enormous weight increase of the pigs. The trabeculae aligned at later stages when the increase in weight, and thus the loading, was slowed considerably compared with the early growth stage. Hence, the trabecular architecture was more efficient in later years. We conclude that density is adapted to external load from the early phase of growth, whereas the trabecular architecture is adapted later in the development.

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“…These -FEA models have been shown to give accurate estimates of the apparent elastic moduli of cancellous bone. 10,12,16,22 A tissue modulus of 5 GPa was assumed for all specimens.…”

Section: Morphometric and Mechanical Analysismentioning

confidence: 99%

Increase in bone volume fraction precedes architectural adaptation in growing bone

Tanck

Homminga

Lenthe

et al. 2001

Bone

177

140

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“…Mechanical testing of spinal specimens can be carefully well-prepared, however, to measure the mechanical characteristics and effective tissue moduli of the objects may have some uncertainties and additional errors due to the experimental boundary conditions, namely, due to the differences between model and experiment, in particular how the experimental boundary conditions are modelled. 1 Among others, material and embedding techniques highly influence the measured values, mainly for cellular structures. To determine the dependence of effective tissue properties on the applied boundary conditions and quantifying errors was investigated in 1,2 by using finite element method.…”

Section: Introductionmentioning

confidence: 99%

Experimental and numerical analysis of the influence of embedding thickness in compressive mechanical testing of vertebral augmentation and spinal interbody fusion

Kovács¹,

Nédli²,

Варга³

et al. 2013

Biomech Hung

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For in vitro mechanical testing of biomechanical objects the specimens must generally be embedded into a special material to obtain a stable position in the testing machine. However, the experimental boundary conditions may influence the results of the measurements. In this study the effect of embedding thickness on the mechanical properties of vertebrae treated by vertebroplasty and kyphoplasty and lumbar motion segments treated by interbody fusion with PEEK and PMMA cement spacers is analyzed by using compressive mechanical tests and QCT based specimen-specific finite element simulation.

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“…The effect of the internal architecture on the resulting mechanical deformations and fluid dynamics were found to vary according to the morphology of the material. Significantly, Sandino et al (2008) suggested that any non-uniformity in the scaffold architecture will create localised areas of high strain, stress and/or fluid flow, that in-turn will create localised hotspots of mechanical stimuli imparted onto the cells ®»ª·-»¼ ³¿²«-½®·°¬ Ý´·½µ¸»®» ¬± ª·»©´·²µ»¼ Î»º»®»²½»-Though many previous µFE (FE analysis at microscale resolution) models of scaffolds have sampled small regions of interest [Sandino et al, 2008;Lacroix et al, 2006], large-scale µFE modelling (consisting of many millions of elements) has been used successfully in other domains, particularly in the study of trabecular and cancellous bone [Harrison et al, 2008;Jacobs et al, 1999]. By representing a large proportion of the structure, or even the entire assembly if computational capacity allows, large-scale µFE affords a comparison of regional variances in one single analysis.…”

mentioning

confidence: 99%

Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis

Stops¹,

Harrison²,

Haugh³

et al. 2010

Journal of the Mechanical Behavior of Biomedical Materials

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The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling

Cited by 61 publications

References 11 publications

Increase in bone volume fraction precedes architectural adaptation in growing bone

Increase in bone volume fraction precedes architectural adaptation in growing bone

Experimental and numerical analysis of the influence of embedding thickness in compressive mechanical testing of vertebral augmentation and spinal interbody fusion

Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis

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