The impact of body mass index on assisted reproduction

Erel, C. Tamer; Şentürk, Levent M.

doi:10.1097/gco.0b013e32832aee96

Cited by 83 publications

(39 citation statements)

References 75 publications

(118 reference statements)

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“…Endometrial receptivity may be impaired in obese women. These mechanisms may be responsible for a decrease in implantation and pregnancy rates as well as an increase in miscarriage rate, yielding to a poorer outcome in obese women in assisted reproduction [12,13]. The mechanism underlying the inverse relationship between obesity and AMH is not entirely clear.…”

Section: Discussionmentioning

confidence: 99%

“…There is abundant evidence that increased body mass index (BMI) has a significant adverse effect on pregnancy and miscarriage rates in women seeking to become pregnant naturally [12,13]. Attention has been paid to the causes of poor fertility outcomes in overweight women, seeking to determine whether these outcomes are due to an ovarian or endometrial effect [13].…”

Section: Introductionmentioning

confidence: 99%

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Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

Şahmay

Güralp

Şentürk

et al. 2011

Reprod Medicine & Biology

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Purpose To evaluate the correlation between anti-mülle-rian hormone (AMH) and body mass index (BMI) in patients with and without polycystic ovarian syndrome (PCOS). Methods Serum AMH levels of 332 women in their reproductive period and below 45 years of age who were admitted to our reproductive endocrinology clinic with infertility were investigated in a cross-sectional study. Patients were divided into two groups as BMI under and equal or over 25 kg/m 2 . Both groups were divided into two subgroups as PCOS and non-PCOS. AMH levels of patients were analyzed for each group. Results Mean AMH values of BMI \25 and C25 kg/m 2 groups were 3.87 ± 2.95 and 3.58 ± 2.93 ng/mL, respectively (P [ 0.05) in all patients. Means of AMH were not significantly different in BMI quartiles (r = -0.008401, P = 0.96). Among 107 patients with PCOS, means of AMH were 6.85 ± 2.95 ng/mL in 56 patients with BMI \25 kg/m 2 and 6.66 ± 3.18 ng/mL in 51 patients with BMI C25 kg/m 2 (P [ 0.05). In the group of 225 non-PCOS patients, means of AMH were 2.27 ± 1.12 ng/mL in 104 patients with BMI\25 kg/m 2 and 2.28 ± 1.49 ng/mL in 121 patients with BMI C25 kg/m 2 (P [ 0.05). Conclusions Body mass index does not seem to have an effect on serum AMH levels in reproductive age women both with and without PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum anti‐müllerian hormone concentrations in reproductive age women with and without polycystic ovary syndrome: the influence of body mass index

Şahmay

Güralp

Şentürk

et al. 2011

Reprod Medicine & Biology

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“…In Bellver et al, 2010, this result was also found with p value of 0.001. In Erel et al, 2009 review, several articles were evaluated. Some have shown that higher dose it is necessary, while in others not.…”

Section: Dose Of Gonadotropinsmentioning

confidence: 99%

“…Obese may be further divided into classes: Class I with BMI 30 to 34.9 kg/m², Class II 35 to 39.9 kg/m² and class III when greater than or equal to 40 kg/m². In the last decade, the global trend shows an increase of about 40% of overweight and obesity in women of reproductive age (Erel et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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“…The subfertility in obese women is partly ascribed to the complete absence or reduced frequency of ovulation (53). Obesity has been reported to have a negative impact on assisted reproduction techniques because it adversely affects the duration of stimulation of the ovaries, fertilization rate, quality, and some oocytes and embryos, the rate of embryo transfer, and pregnancy rates (54). Consequently, obese women have been shown to require higher doses of gonadotropins and longer durations of ovarian stimulation.…”

Section: Ovarian Functionmentioning

confidence: 99%