Metabolic Syndrome and Infertility in Women

Awlaqi, Ahmed Al; Alkhayat, Khalid; Hammadeh, Mohamad Eid

doi:10.15296/ijwhr.2016.23

Cited by 15 publications

(9 citation statements)

References 57 publications

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“…The androgen excess is manifested as hirsutism, acne/seborrhea while the chronic anovulation is manifested as oligomenorrhea/amenorrhea and reduction in fertility rate. Furthermore, PCOS is associated with dyslipidemia, obesity, insulin resistance, and multiple ovarian cysts [5]. The action of the gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) regulates steroidogenesis [6].…”

Section: Introductionmentioning

confidence: 99%

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Ainehchi

Khaki

Ouladsahebmadarek

et al. 2020

aoms

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Introduction: To evaluate the effect of a herbal mixture (i.e., Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, and Citrus sinensis) alone and in combination with clomiphene citrate (CC) compared to CC on the treatment of polycystic ovary syndrome (PCOS). Material and methods: This single-blind randomized clinical trial was conducted on 60 infertile participants with PCOS who were randomly divided into three groups. After spontaneous or progestin-induced withdrawal bleeding, group 1 (n = 20) received routine treatment with CC (50-150 mg) for three menstrual cycles from the 3 rd to 5 th day of menstruation for 5 days while group 2 (n = 20) and group 3 (n = 20) received herbal mixture capsules 700 mg/day and the herbal mixture along with CC for 3 months, respectively. Finally, several related parameters were measured, including the level of sex steroids, homeostatic model assessment for insulin resistance (HOMA-IR), lipid profile (primary outcomes), thyroid hormones, and clinical features. The analysis was based on intention-to-treat analysis. Results: No statistically significant differences were observed between the groups in terms of socio-demographic characteristics. However, after adjustment for baseline, luteinizing hormone (aMD = 4.9; 95% CI: 3.7-6.2), luteinizing hormone/follicle-stimulating hormone (aMD = 0.9; 95% CI: 0.7-1.2), total testosterone (aMD =-0.12; 95% CI:-0.2 to-0.01) in group 2 and free testosterone (aMD =-6.0; 95% CI:-9.7 to-2.3) in group 3 revealed a significant difference compared to group 1. In addition, HOMA-IR in group 2 (aMD =-1.3; 95% CI:-2.4 to-0.2) decreased significantly compared to group 1. Further, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol decreased significantly

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Section: Introductionmentioning

confidence: 99%

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Ainehchi

Khaki

Ouladsahebmadarek

et al. 2020

aoms

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“…Hormones such as insulin and IGF1 appear to be needed to couple reproduction to energy metabolism across a range of organisms and their tissues [36,37]. If this mechanism extends to humans, the insulin resistance that underlies metabolic syndrome and associated female infertility (reviewed [38]) may be connected to the inability of insulin to affect the ability of ovarian hormones (E 2 and P 4 ) to properly change carbohydrate use in uterine tissues.…”

Section: Discussionmentioning

confidence: 99%

Estradiol and progesterone affect enzymes but not glucose consumption in a mink uterine cell line (GMMe)

2020

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Cells lining the uterus are responsible for storage and secretion of carbohydrates to support early embryonic development. Histotrophic secretions contain glycogen and glycolytic products such as lactate and pyruvate. Insufficient carbohydrate storage as glycogen has been correlated with infertility in women. While it is clear that changes in estrogen (17-β-estradiol (E2)) and progesterone (P4) in vivo affect the distribution of glucose in the uterine cells and secretions, the biochemical mechanism(s) by which they affect this crucial allocation is not well understood. Furthermore, in cultured uterine cells, neither E2 nor P4 affect glycogen storage without insulin present. We hypothesized that P4 and E2 alone affect the activity of glycolytic enzymes, glucose and glycolytic flux to increase glycogen storage (E2) and catabolism (P4) and increase pyruvate and lactate levels in culture. We measured the rate of glucose uptake and glycolysis in a mink immortalized epithelial cell line (GMMe) after 24-h exposure to 10 μM P4 and 10 nM E2 (pharmacologic levels) at 5 mM glucose and determined the kinetic parameters (Vmax, Km) of all enzymes. While the activities of many glycolytic enzymes in GMMe cells were shown to be decreased by E2 treatment, in contrast, glucose uptake, glycolytic flux and metabolites levels were not affected by the treatments. The cellular rationale for P4- and E2-induced decreases in the activity of enzymes may be to prime the system for other regulators such as insulin. In vivo, E2 and P4 may be necessary but not sufficient signals for uterine cycle carbohydrate allocation.

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“…There is a relationship between the women’s health history and infertility. For example, thyroid diseases ( 10 ), multiple sclerosis ( 11 ), diabetes ( 12 ) and metabolic syndrome ( 13 ) can be causes of infertility. More specifically, the polycystic ovary syndrome is one of the most common reproductive endocrinological disorders in women, affecting about 15% of the general population and is associated with the metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, the polycystic ovary syndrome is one of the most common reproductive endocrinological disorders in women, affecting about 15% of the general population and is associated with the metabolic syndrome. Evidence has shown that insulin resistance plays an important role in pathophysiology of polycystic ovary syndrome ( 13 ), while the compensatory hyperinsulinemia is also a key factor in the evolution of metabolic syndrome ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

The Kind of Conception Affects the Kind of Cesarean Delivery in Primiparous Women

Antoniou¹,

Orovou²,

Iliadou³

et al. 2021

Mater Sociomed

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Background: So far, multiple factors have been found to be related to the IVF procedure, the most prevalent being extremes of maternal age, infections, previous gynecological history, infertility and others. Although women achieve the coveted pregnancy with the development of IVF technology, the rapid increase contributes to the increase of primary cesarean sections rates. Objective: The aim of the study was to identify if the kind of conception affects the kind of cesarean delivery among primiparous women in Greece. Methods: This cross-sectional observational study took place from September 2019 to February 2020 at the University Hospital of Larisa in Greece. One hundred and sixty-two primiparous women who underwent a cesarean section (c-section) after IVF (n=27) and natural conception (n=135) participated in the study. Results: The mean age of the IVF and natural conception groups were 36.22 and 31.08 years, respectively. Nineteen (70.4%) women of the IVF group had a previous medical or gynecological history in contrast to 48 (35.6%) women of the natural conception group. Only 55.6% of the IVF group had a full-term pregnancy unlike 88.1% of women in the natural conception group. An elective c-section was performed in 18 (66.7%) of the women who conceived after IVF, as opposed to 45 (33.3%) of the women who conceived naturally. Conclusion: This cross-sectional study showed that IVF conception was associated with high rates of elective cesarean section as opposed to women with natural conception. The causes of c-sections must be evidence based because the primary cesarean delivery is a major factor contributing to increased c-section rates.

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Metabolic Syndrome and Infertility in Women

Cited by 15 publications

References 57 publications

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial

Estradiol and progesterone affect enzymes but not glucose consumption in a mink uterine cell line (GMMe)

The Kind of Conception Affects the Kind of Cesarean Delivery in Primiparous Women

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