The Immunosuppressive Effects ofGlobularia alypumExtracts

Tentative Characterisation of Iridoids, Phenylethanoid Glycosides and Flavonoid Derivatives from Globularia alypum L. (Globulariaceae) Leaves by LC‐ESI‐QTOF‐MS

“…Moreover, this plant has been used to treat haemorrhoids and cardiovascular diseases. More recently, it has been found that the extracts from the whole plant reduced histamine and serotonin contraction in vitro and were active against lymphocytic leukaemia P-388 and neoplastic cell culture (Fehri et al, 1996;Bello et al, 2002;Es-Safi et al, 2006). It was also found to have anti-viral activity against polio (Soltan and Zaki, 2009).…”

“…Concentrated decoctions of young branches and leaves are used in the treatment of boils and intermittent fever. Leaves are used to treat rheumatism and arthritis, and they have been found to have anti-tumour effects as well as phytotoxic potential (Fehri et al, 1996;Elbetieha et al, 2000).…”

Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves

“…The hydromethanolic extract of G. alypum could thus be considered as a source of potential antioxidants and may promote the reasonable usage of this plant in food technology and processing as well as for medical use [ 10 ]. It was used as a hypoglycemic agent [ 11 ], for its fetotoxic potentials [ 12 ], immunosuppressive effects [ 13 ], laxative and purgative effects, stomachic role, and also in the treatment of cardiovascular and renal diseases [ 14 ].…”

Chemical Composition and Antioxidant Activity of Globularia Alypum L. Leaves Essential Oil from Ain-Defla (Algeria)

“…Several studies showed that various extract of G.alypum could thus be considered as a source of potential antioxidants [17,18]. Also, G.alypum extracts shown to reduce histamine and serotonin contraction in vitro [19] and were significant sources of compounds with anti-leukemic [20], immunosuppressive [21], anti-ulcer [22], myorelaxant and spasmolytic [23], antigenotoxic [24], anti-tuberculosis [25] and antiinflammatory activities [26]. The large-scale use of this plant for the treatment of many diseases, in addition to the fact that only few studies have been carried out on the Algerian G.alypum essential oil, prompted us to investigate the chemical composition of essential oil of this plant and its antioxidant activity.…”