The immunomodulatory activity of secondary metabolites isolated from<i>Streptomyces calvus</i>on human peripheral blood mononuclear cells

Mahmoudi, Fariba; Baradaran, Behzad; Dehnad, Alireza; Shanehbandi, Dariush; Khosroshahi, Leila Mohamed; Aghapour, Mahyar

doi:10.1080/09674845.2016.1188476

Cited by 7 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mahmoudi et al [26] studied the response of peripheral blood mononuclear cells to co-culture with extracts of Streptomyces calvus. Unsurprisingly, cell proliferation was marked, but in addition, our colleagues noted an increased expression of genes coding for pro-inflammatory IL-2 and IFN-γ, and a reduction in the expression of the gene for the immunosuppressive cytokine IL-10.…”

Section: Immunologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

View full text Add to dashboard Cite

In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

show abstract

Section: Immunologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

View full text Add to dashboard Cite

show abstract

“…Immunostimulants are a diverse collection of chemicals that act on the immune system in a non-specific way by activating it, either by upregulating it or by favoring the activity of one of its components ( Ortuño-Sahagún et al, 2017 ). Secondary metabolites from Streptomyces bacteria have a wide range of immunomodulatory activity made a significant contribution to immunomodulatory therapies ( Mahmoudi et al, 2016 ).…”

Section: Natural Products From Streptomycesmentioning

confidence: 99%

“…Secondary metabolites from S. calvus have been shown to be effective immunomodulators in human peripheral blood mononuclear cells (PBMCs) ( Mahmoudi et al, 2016 ). Short polyketides generated by several streptomycetes and related bacteria that have strong anti-inflammatory and pro-apoptotic properties are known as manumycin-type compounds ( Figure 6 ; Hrdý et al, 2020 ).…”

Section: Natural Products From Streptomycesmentioning

confidence: 99%

Streptomyces: The biofactory of secondary metabolites

et al. 2022

View full text Add to dashboard Cite

Natural products derived from microorganisms serve as a vital resource of valuable pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial genus in the environments with prolific capability to produce diverse and valuable natural products with significant biological activities in medicine, environments, food industries, and agronomy sectors. However, many natural products remain unexplored among Streptomyces. It is exigent to develop novel antibiotics, agrochemicals, anticancer medicines, etc., due to the fast growth in resistance to antibiotics, cancer chemotherapeutics, and pesticides. This review article focused the natural products secreted by Streptomyces and their function and importance in curing diseases and agriculture. Moreover, it discussed genomic-driven drug discovery strategies and also gave a future perspective for drug development from the Streptomyces.

show abstract

“…2). Colonization of commensal microorganisms in the gastrointestinal tract after birth is required for the immune system maturation, especially the development of the gut mucosal immune system, which influences the host's tolerance mechanisms to differentiate between commensal bacteria (quasi-self and tolerated antigens) and pathogenic bacteria [24][25][26][27]. Intestinal epithelial cells (IECs) present a physical and biochemical barrier isolating the intestinal lumen from the inside of the body.…”

Section: Interaction Between Microbiota and Immune Systemmentioning

confidence: 99%

Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer

Azimi

Shahbaz

Mansourabadi

et al. 2022

Int Arch Allergy Immunol

View full text Add to dashboard Cite

The human colon harbors a diverse array of microorganisms that play fundamental roles in colorectal cancer (CRC). Increasing evidence indicates that dysbiosis of the intestinal microbiome has been associated with the development of CRC. Interaction between host genetics, intestinal microbiota, and lifestyle is well-indicated in the influence, prevention, and treatment of CRC. Various microbiome compositions have reported anticancer and/or anti-inflammatory properties. The presence of our microbiota is integral to our development, but a change in its composition can often lead to adverse effects, increasing the propensity for serious diseases like cancers. Recently, molecular detection and metabolomic techniques have increased our knowledge of the role of microbiota in promoting tumorigenesis. Dietary interventions may be appropriate to regulate the growth of beneficial microbiota in the gut. Metagenomic approaches along with immunology and metabolomics will obvious a new path for the treatment of CRC. In this study, we summarized recent advances in understanding the mechanisms involved in microbiota-related colorectal carcinoma, based on evidence from immunotherapy studies.

show abstract

The immunomodulatory activity of secondary metabolites isolated fromStreptomyces calvuson human peripheral blood mononuclear cells

Abstract: This in vitro study revealed that the secondary metabolites from S. calvus can successfully stimulate human PBMCs. Therefore, these metabolites have the potential to serve as robust immunomodulators.

Cited by 7 publications

References 26 publications

British Journal of Biomedical Science in 2016. What have we learned?

British Journal of Biomedical Science in 2016. What have we learned?

Streptomyces: The biofactory of secondary metabolites

Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer

Contact Info

Product

Resources

About