British Journal of Biomedical Science in 2016. What have we learned?

Blann, Andrew D.

doi:10.1080/09674845.2016.1271567

Cited by 3 publications

(1 citation statement)

References 74 publications

(71 reference statements)

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“…Zhou et al [5] found in their research that, in patients with RA, miR-146a facilitated a pro-inflammatory phenotype of Tregs via increased STAT1 activation, and contributed thereby to RA pathogenesis. Abdulmaksoud et al [6] revealed that both miR-210 and miR-155 were closely related with RA disease activity. Serum miR-210 and miR-155 were two independent diagnostic markers for RA and could be served as non-invasive biomarkers for the diagnosis of RA.…”

Section: Introductionmentioning

confidence: 99%

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

et al. 2019

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The present study aimed to explore miR-125 effects on rheumatoid arthritis (RA) development to provide a potential target for RA. Briefly, rat RA model was established (Model group) by injection of Freund’s Complete Adjuvant into the left hind toe. Normal rats injected with saline in the same location were set as Normal group. All rats’ secondary foot swelling degree, polyarthritis index score, spleen and thymus index were measured. Synovial tissues were subjected to Hematoxylin–Eosin (HE) staining and immunohistochemistry. Synovial cells of each group were isolated and named as Normal-C group and Model-C group, respectively. Synovial cells of Model-C group further underwent cotransfection with miR-125 mimics and PARP2-siRNA (mimics+siPARP2 group) or with miR-125 negative control (NC) and PARP2-siRNA NC (NC group). Quantitative reverse transcriptase PCR (qRT-PCR), Western blot, luciferase reporter assay, ELISA, and MTT assay were performed. As a result, compared with Normal group, rats of Model group showed significantly higher secondary foot swelling degree, polyarthritis index score, spleen and thymus index (P<0.01). Down-regulated miR-125 and up-regulated PARP2 was found in synovial tissues of Model group when compared with Normal group (P<0.01). Synovial tissues of Model-C group exhibited severe hyperplasia and inflammatory cell infiltration. Luciferase reporter assay indicated that PARP2 was directly inhibited by miR-125. Compared with NC group, cells of mimics+siPARP2 group had significantly lower IL-1β, MMP-1 and TIMP-1 levels, absorbance value, and p-PI3K, p-Akt and p-mTOR relative expression (P<0.01 or P<0.05). Thus, miR-125 might attenuate RA development by regulating PI3K/Akt/mTOR signaling pathway via directly inhibiting PARP2 expression.

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Section: Introductionmentioning

confidence: 99%

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

et al. 2019

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British Journal of Biomedical Science in 2017: What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2017 the British Journal of Biomedical Science published 35 articles in the various disciplines that comprise biomedical science. These were 6 reviews, 22 original articles, 6 'In Brief' short reports and one guideline. Of these, the majority were in clinical chemistry (one review, six data papers), microbiology (one review, four data papers), cellular pathology (four data papers) and virology (one review, two data papers). There were two data papers in transfusion science, whilst haematology, cytopathology and immunology were each represented by one review and one data paper. Reflecting the increasing complexity of the laboratory, five data papers crossed barriers between traditional disciplines, and so may be described as multidisciplinary. The present report will summarise key aspects of these publications.

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British Journal of Biomedical Science in 2018: what have we learned?

Blann

2018

British Journal of Biomedical Science

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In 2018 the British Journal of Biomedical Science published one guideline (in reproductive science) and 40 research articles in the various disciplines the comprise biomedical science. The latter were 24 original articles and 16 'In Brief' short reports. Of these, 23 are of note to only one of the subdisciplines (seven each to biochemists and microbiologists, six to cell pathologists, and one each to cytologists, immunologists and reproductive scientists). Reflecting the increasing complexity of laboratory science, thirteen papers crossed one boundary (three papers each relevant to biochemists and immunologists, and to haematologists and biochemists), whilst four papers were relevant to three or more disciplines. Indeed, biochemical techniques were used in 18 papers, microbiological techniques in 9, whilst histopathology was relevant to 11 papers. Notably, 20 papers used techniques in chromosome analysis and molecular genetics. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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British Journal of Biomedical Science in 2016. What have we learned?

Cited by 3 publications

References 74 publications

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

British Journal of Biomedical Science in 2017: What have we learned?

British Journal of Biomedical Science in 2018: what have we learned?

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