The Immunological Enhancement Activity of Propolis Flavonoids Liposome<i>In Vitro</i>and<i>In Vivo</i>

Tao, Yang; Wang, Deqing; Hu, Yuanliang; Huang, Yee; Yu, Yun; Wang, Deyun

doi:10.1155/2014/483513

Cited by 26 publications

(23 citation statements)

References 39 publications

(34 reference statements)

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“…It is important to notice that the diversity of compounds observed is consistent with data from literature (Maróstica Jr et al 2008;Cueto et al 2011;Morlock et al 2014). The identified compounds are described as important in the defense to oxidative damage of biological molecules and able to aid in the treatment of various pathologies (Tao et al 2014).…”

Section: Discussionsupporting

confidence: 84%

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

et al. 2016

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The composition of propolis depends on time, vegetation and the location of the collection area. The objective of this study was to determine the physicochemical characteristics, the concentration of phenol compounds and the antioxidant capacity of propolis of native stingless bees (Meliponinae) and Apis from the State of Tocantins. Extraction with 80% ethanol (v/v) was performed in order to obtain the extracts. Parameters examined were: propolis mass loss by desiccation at 105 ºC, ashes, wax concentration and pH. Furthermore, the propolis antioxidant activity was measured, as well as the total concentration of phenol compounds. The extracts were also analyzed by high performance liquid chromatography. The total concentration of phenol compounds varied between 121.78 and 631.29 (mg GAE g . High performance liquid chromatography analysis allowed us to infer the existence of phenol compounds. The results indicated that the studied propolis samples constitute good sources of natural antioxidants. The variety of phenol compounds identified in this study, and the diverse biological functions reported in literature for these compounds indicated that this stingless bee propolis (Meliponinae) and Apis has a high pharmacological potential. KEYWORDS: Propolis, antioxidant, phenol compounds.Propriedades físico-químicas e capacidade antioxidante de própolis de abelhas sem ferrão (Meliponinae) e Apis de duas regiões do Tocantins, Brasil RESUMO A composição da própolis depende do tempo, da vegetação e a localização da área de coleta. Este estudo teve como objetivo determinar as características físicas e químicas, o teor de compostos fenólicos e capacidade antioxidante da própolis de abelhas nativas sem ferrão (Meliponinae) e Apis do Estado do Tocantins. Para a obtenção dos extratos empregou-se extração com etanol 80% (v/v). Os parâmetros analisados foram: perda de peso por dessecação a 105 °C, cinzas, Teor de cera e pH. Além dessas foi mensurada a atividade antioxidante e o teor de compostos fenólicos totais. Adicionalmente os extratos de própolis foram também analisados por cromatografia líquida de alta eficiência. O teor de compostos fenólicos totais variou entre 121,78 e 631,29 (mg GAE g -1 ). A atividade antioxidante expressa pelo valor de CE 50 variou entre 29,81 e 845,38 µg mL -1 . As análises por cromatografia líquida de alta eficiência permitiram inferir a existência de compostos fenólicos. Os resultados indicaram que as amostras de própolis estudadas constituem boas fontes de antioxidantes naturais. A variedade de compostos fenólicos identificada neste estudo, e as diversas funções biológicas relatadas na literatura para estes compostos, indicaram que a própolis de abelhas sem ferrão (Meliponinae) e Apis tem um grande potencial farmacológico. PALAVRAS-CHAVE: Própolis, antioxidante, compostos fenólicos. Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apis from two regions of Tocantins, Brazil ACTA

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Section: Discussionsupporting

confidence: 84%

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

et al. 2016

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“…74 In addition, Immune stimulatory 71 many of the compounds that show immunostimulatory activity are not water soluble, and so have been used with lipid vesicles such as liposomes to increase their bioavailability. 70 Flavonoid-rich liposomes enhanced antigen-specific IgG antibodies and induced IFN-g and IL-4, compared with propolis alone. In vivo studies by Orsatti et al, 67 revealed that propolis activated the initial steps of the immune response by upregulating Toll-like receptors (TLR2 and TLR4) and production of proinflammatory IL cytokines (IL-1b and IL-6) in mice, thereby modulating the mechanisms of innate immunity.…”

Section: Propolismentioning

confidence: 97%

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Woods

Niwasabutra

Acevedo

et al. 2017

Immunopotentiators in Modern Vaccines

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“…Improvement of the IMS homeostatic functions can also be induced by honey bee propolis[105-107]. Available data indicate that the propolis utilization strengthens the body’s IMS and activates the thymus[99-102].…”

Section: Can the Aging Be Delayed?mentioning

confidence: 99%

“…The propolis oral gavage might be beneficial for the treatment of periodontitis[112]. The propolis flavinoids could activate the IMS in mice[107]. Regarding the gonads, the propolis prevented toxic effects of methoxychlor on rat ovaries[113] and had a protective effect for the function of sperm[114-119].…”

Section: Can the Aging Be Delayed?mentioning

confidence: 99%

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

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The Immunological Enhancement Activity of Propolis Flavonoids LiposomeIn VitroandIn Vivo

Cited by 26 publications

References 39 publications

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

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