The Immunohistochemical Effect of a Hydrocolloid Occlusive Dressing (DuoDERM E) in Psoriasis vulgaris

Abstract

The topical application of a hydrocolloid occlusive dressing (HCD) has been shown in various studies to have an antipsoriatic effect as monotherapy but especially in combination with a topical corticosteroid. The aim of the present study was to assess the effect of 3 weeks of HCD monotherapy at the immunohistochemical level. Ten patients were treated. Before and after treatment, a biopsy was taken, and immunohistochemical stainings were carried out with markers for epidermal growth, keratinization, inflammation and endothelium. Suprabasal expression of keratin 16, the number of cycling epidermal cells and the number of polymorphonuclear leucocytes and T lymphocytes tended to decrease during treatment. The endothelial markers did not change during HCD treatment. This study confirms the antipsoriatic effect of HCD and demonstrates that its effect upon some markers of inflammation, epidermal proliferation and keratinization is modest.

Efficacy of Calcipotriol Ointment Applied under Hydrocolloid Occlusion in Psoriasis

“…The clinical efficacy of HCD has been described earlier [19, 20]. However no statistically significant immunohistochemical effects were reported on keratin 16 and MIB-1 expression [19].…”

“…However no statistically significant immunohistochemical effects were reported on keratin 16 and MIB-1 expression [19]. The exact mode of action of a HCD is still unknown.…”

A new formulation of an occlusive dressing containing betamethasone valerate 0.1% in the treatment of mild to moderate psoriasis

“…During the last decade, treatment with corticosteroids under occlusive dressings has become a popular approach 11 . Even when used alone, but especially when used under occlusion, emollients can have a beneficial effect on psoriatic plaques, softening the affected area to increase penetration of the active agent 12 . The medium‐potency glucocorticoid betamethasone valerate (BMV), approved for market in 1967 for the treatment of severe inflammatory skin disorders, is currently available in cream, ointment, lotion and foam formulations at 0.1% concentration.…”

Skin barrier response to occlusion of healthy and irritated skin: Differences in trans‐epidermal water loss, erythema and stratum corneum lipids

“…In daily life, the problem arises when occlusive gloves are used for protection of the hands in work settings (1–3). On the other hand, occlusive treatment has a positive effect on skin healing (4–6). The effect of occlusion on damaged skin may, however, depend on the nature of the trauma, and no consensus on the effect of occlusion has been reached in the literature.…”