A new formulation of an occlusive dressing containing betamethasone valerate 0.1% in the treatment of mild to moderate psoriasis

Pacifico, Alessia; Daidone, R; Peris, Ketty

doi:10.1111/j.1468-3083.2006.01387.x

Cited by 22 publications

(34 citation statements)

References 26 publications

(19 reference statements)

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“…The time course of the clinical effects also matched those seen in other clinical studies, with a fast onset by Daivobet ® already showing significant clinical effect at day 4. As in other topical psoriasis studies a significant vehicle effect was observed, with a reduction of 37% in the total clinical score over three weeks by the ointment vehicle alone [7]. In this study a treatment arm with betamethasone diproprionate ointment alone was not included as the effects of betamethasone and Daivobet has been compared in another plaque test study.…”

Section: Discussionmentioning

confidence: 92%

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

et al. 2009

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The aim of the present study was to compare the effects of Daivobet® and calcipotriol on clinical score and biomarker responses in a modified version of the Scholtz-Dumas psoriasis plaque assay. Furthermore, it was the aim to compare the effects of calcipotriol and betamethasone in the murine psoriasis xenograft model. Twenty four patients with psoriasis were treated topically once daily for three weeks, whereas the grafted mice were treated for four weeks. Clinical responses were scored twice weekly and biopsies were taken at the end of each study to analyse for skin biomarkers by histology and immunohistochemistry. The results clearly demonstrate effects on both clinical signs and biomarkers. In the patient study the total clinical score was reduced significantly with both Daivobet® and calcipotriol. Both treatments reduced epidermal thickness, Ki-67 and cytokeratin 16 expression. T cell infiltration was significantly reduced by Daivobet® but only marginally by calcipotriol. Both treatments showed strong effects on the epidermal psoriatic phenotype.Results from the xenograft model essentially showed the same results. However differences were observed when investigating subtypes of T cells.The study demonstrates the feasibility of obtaining robust biomarker data in the psoriasis plaque test that correlate well with those obtained in other clinical studies. Furthermore, the biomarker data from the plaque test correlate with biopsy data from the grafted mice.

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Section: Discussionmentioning

confidence: 92%

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

et al. 2009

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“…Ten grade A 2 studies on topical steroid monotherapy were included [116][117][118][119][120][121][122][123][124][125], 17 grade B studies [104,[126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141], and two grade C studies [142,143]. Ten grade A 2 studies on topical steroid monotherapy were included [116][117][118][119][120][121][122][123][124][125], 17 grade B studies [104,[126][127][128][129][130][131][132][133][134]…”

Section: Efficacymentioning

confidence: 99%

S3 – Guidelines on the treatment of psoriasis vulgaris Update 2011

Nast

Boehncke

Mrowietz

et al. 2011

J Deutsche Derma Gesell

155

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“…Furthermore, previous studies also reported adverse effects caused by transdermal plasters, such as contact dermatitis, sensitization, and delayed hypersensitivity 28–44. As far as BMV plaster safety is concerned, Pacifico et al13 reported no serious local or systemic treatment-related adverse effects during 30 days of treatment in patients affected by mild-to-moderate psoriasis. No adverse effects were also reported by Saraceno et al16 in patients affected by prurigo nodularis treated for 4 weeks with BMV plasters, and by Naldi et al14 in patients affected by mild-to-moderate chronic plaque psoriasis treated with BMV plaster for 3–5 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have confirmed the superiority of BMV plasters over the cream formulation. In 2006, Pacifico et al13 enrolled 42 patients with mild-to-moderate psoriasis. The patients involved in this study were treated, in a half-side distribution, with a BMV 0.1% tape and BMV 0.12% cream for 30 days.…”

Section: Introductionmentioning

confidence: 99%

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

Iannitti¹,

Rottigni²,

Palmieri³

2013

DDDT

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Background and aimThe use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methodsWe applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group.ResultsBetesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01).ConclusionThe present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation.

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A new formulation of an occlusive dressing containing betamethasone valerate 0.1% in the treatment of mild to moderate psoriasis

Abstract: Our results indicate a higher efficacy of BMV 0.1% tape compared with BMV 0.12% cream in the treatment of mild to moderate chronic plaque psoriasis.

Cited by 22 publications

References 26 publications

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model

S3 – Guidelines on the treatment of psoriasis vulgaris Update 2011

Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

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