Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

Abstract

Background and aimThe use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure.Materials and methodsWe applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group.ResultsBetesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01).ConclusionThe present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation.

Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway

“…In addition, cell swelling, edema and inflammation are closely related. It has been proved that edema could cause neuron dysfunction, and most of studies considered that BBB dysfunction is the main reason for brain edema [ 45 , 46 ]. In this study, we found that rats showed obvious subependymal edema which was nonvascular origin, while NLRP3 was widely activated in microglia/macrophages on day 3 after ICH-IVH.…”

Transdermal application of azithromycin-amlodipine-heparin gel enhances survival of infected random ischaemic flap

“…Unlike systemic drugs, to create a pharmacological effect and avoid unwanted side-effects they should quickly penetrate the skin flap, maintain topical effective concentrations, and there should be limited escape to the systemic circulation. Further considerations are that drugs applied in combination may compete for routes of entry and affect each other, and usually compounds more than 800 kD permeate skin tissue less easily [25]. In a previous study we demonstrated that AZM and AB could transdermally penetrate skin flaps and increase the flap survival area [1,2].…”

Use of Triamcinolone to Reduce the Inflammation Associated with Kybella Injection

“…Copyright: © 2020 Nwanneka Okwundu, et al methods have been employed to alleviate these adverse effects including ice, NSAIDs, topical or injectable amides anesthetics, vibration, and botulinum toxin injection for pain reduction [4,14,15]. A small study showed that transdermal treatment with corticosteroids immediately after hyaluronic acid injections reduced swelling [16]. Hence, we utilized triamcinolone to alleviate the inflammatory effects of the Kybella injection and observed for changes in inflammatory response and patient outcome.…”