Skin barrier response to occlusion of healthy and irritated skin: Differences in trans‐epidermal water loss, erythema and stratum corneum lipids

Abstract

A week of occlusion did not significantly affect healthy skin, but was found to decrease healing of SLS-damaged skin, and to improve healing of tape-stripped skin.

Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment

“…-enhances the efficacy of scar treatment; -stimulates angiogenesis which causes the creation of new capillaries (Schroeder et al, 2007;Berman and Flores, 1999;Berman et al, 2007;Wolfram et al, 2009;Pikuła et al, 2014;Jungersted et al, 2010;Gold et al, 2001;Stavrou et al, 2010;Tandara and Mustoe, 2008;Gallant-Behm and Mustoe, 2010;Kloeters et al, 2007;Gilman, 2003a,b) Increases the hydration of stratum corneum which enables the permeation of active substances to the skin. The limited permeation of water vapor prevents drying and apoptosis of epidermal cells and enhances epidermal migration Hydration of stratum corneum -inhibits either of fibroblasts proliferation or collagen synthesis occurs; -softens the epidermis which decreases undesired symptoms (pain, pruritus, contraction) (Wolfram et al, 2009;Suetake et al, 2000;Sawada and Sone, 1992) Enables the permeation of active substances and stimulation of many processes which provide homeostasis…”

“…The occlusive properties of silicone film DLASil were calculated on a basis of the measurements of water vapor permeability (WVP) (Jungersted et al, 2010;Wissing and Muller, 2002;Casiraghi et al, 2002). They were expressed as an occlusion factor F [%] and calculated by using Formula (2) (Section 2.5).…”

Nonallergic Reactions to Medical Tapes

“…22 In addition to sweat acting as a direct irritant, plugging of eccrine ducts may induce miliaria, starting an inflammatory cascade. The effect of occlusion alone is known to alter skin physiology by raising skin temperature, which induces sweating, and by increasing skin pH, which can alter lipid synthesis.…”

Impact of glove occlusion on cumulative skin irritation with or without hand cleanser–comparison in an experimental repeated irritation model

“…Its irritant effects are considered to arise from the accumulation of moisture. Additional effects on the skin are considered to arise from increased temperature, sweating, and increased pH (28). The duration of occlusion is decisive for the irritant effects to occur, probably because time is needed for the moisture to build up.…”