The Immune System Drugs in Fish: Immune Function, Immunoassay, Drugs

Kum, Cavit; Sekkin, Selim

doi:10.5772/26869

Cited by 32 publications

(29 citation statements)

References 147 publications

(209 reference statements)

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“…Therefore, we hypothesized that inflammation is induced after sub-chronic Cd exposure. TNF-α, IL1β, IL6, and NF-κB are commonly used biomarkers of inflammation (Elsabahy and Wooley, 2013;Xu et al, 2015), and TNF-α, IL1β, and IL6 are predominant pro-inflammatory cytokines in fish (Kum and Sekkin, 2011). The significant up-regulation of TNF-α, IL1β, and NF-κB by treatment with higher doses of Cd suggests an inflammatory response.…”

Section: Discussionmentioning

confidence: 97%

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Wang

Liu

Jin

et al. 2016

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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Section: Discussionmentioning

confidence: 97%

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Wang

Liu

Jin

et al. 2016

Comparative Biochemistry and Physiology Part D: Genomics and Pr

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“…Therefore, we can infer that this may have contributed to a direct toxic effect of Cu in these cells. Several studies have shown that high concentrations or long-term exposures to aquatic pollutants, including metals, aromatic hydrocarbons, and pesticides, can have immunosuppressive effects in fish (reviewed in Anderson 1997 andKum andSekkin 2011). Subepithelial EGCs are found in the connective tissue close to blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine and Eosinophilic Granule Cells in the Gills of Tilapia, Oreochromis niloticus: Effects of Waterborne Copper Exposure

Santos

Falcão

Luzio

et al. 2015

Arch Environ Contam Toxicol

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The contamination of aquatic ecosystems with copper (Cu) poses a serious threat to aquatic organisms. Although the histopathological changes caused by Cu in fish gills are well documented, knowledge about the impact of this metal in gill specific cell types, such as neuroendocrine cells (NECs) and eosinophilic granule cells (EGCs), is still limited. In the present work, Nile tilapia (Oreochromis niloticus) were exposed for 21 days to nominal concentrations of Cu (40 and 400 µg L(-1)). Stereological methods were used to estimate the volumetric density of both NECs and EGCs in fish gill filament after 3, 7, 14, and 21 days of exposure. The results showed that Cu significantly increased the relative volume of NECs, whereas the relative volume of EGCs decreased. NECs were more affected by Cu in the first 7 days of exposure, during which a greater increase in their relative volume was observed. The Cu exposure induced a progressive decrease in the relative volume of EGCs, which reached statistical significance after 14 days of exposure. An exception was observed in subepithelial EGCs with a slight increase in their relative volume after 3 days of exposure. Our findings confirm that Cu can modulate both neuroendocrine and immune systems and becomes immunotoxic after a prolonged exposure.

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“…The technology has been applied to detect pathogens in medical sciences (Seto and Gillam, 1994;Depierreux et al, 2000;Watanabe et al, 2001;Thongprachum et al, 2010), agriculture (Lakner et al, 1998;Li et al, 2011;Hua et al, 2012), veterinary medicine (Oh et al, 2006;Waritani et al, 2007) and fisheries (Takahashi et al, 2003;Adams and Thompson, 2008;Gas et al, 2010;Kum and Sekkin, 2011). The technique has been also applied to detect hormones, such as human chorionic gonadotropin in urine, for early detection of pregnancy (May, 1991).…”

Section: Introductionmentioning

confidence: 97%

One-step detection of matured females using immunochromatography measuring kit for aquaculture of the sea cucumber Apostichopus japonicus (Selenka)

Katow

2014

Egyptian Journal of Aquatic Research

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The present study aimed to develop a gonad-stimulating substance-like peptide (GSSL) immunochromatography measuring kit (GIM-Kit) to detect females of the sea cucumber Apostichopus japonicus that are ready for the collection of matured eggs for artificial insemination in hatcheries. A. japonicus is the major species consumed in East Asian countries. With regard to the increasing demand for the species in the region, collecting the minimum number of females for hatching is beneficial for sustaining the livestock and increasing the efficiency of breeding. A prototype GIM-Kit was constructed based on the double-antibody sandwich immunosorbent assay technique using two polyclonal antibodies that were generated against a physiologically active AEIDDLAGNIDY amino acid sequence of GSSL and a 40-nm-diameter colloidal gold-tagged antibody. The GIM-Kit detected as little as 80 ng of GSSL in approximately 0.4 g mL À1 of ovaries that was diluted in distilled water. The detection time was approximately 20 min in the early (April) to mid (May) breeding season. The immunoreaction of the ovaries was high among the females

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The Immune System Drugs in Fish: Immune Function, Immunoassay, Drugs

Cited by 32 publications

References 147 publications

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Transcriptome profiling analysis of rare minnow (Gobiocypris rarus) gills after waterborne cadmium exposure

Neuroendocrine and Eosinophilic Granule Cells in the Gills of Tilapia, Oreochromis niloticus: Effects of Waterborne Copper Exposure

One-step detection of matured females using immunochromatography measuring kit for aquaculture of the sea cucumber Apostichopus japonicus (Selenka)

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